The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.

Abstract:

:Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded that both norharman and ibogaine are inhibitors of withdrawal syndrome in morphine-dependent rats.

journal_name

Behav Brain Res

authors

Cappendijk SL,Fekkes D,Dzoljic MR

doi

10.1016/0166-4328(94)90080-9

subject

Has Abstract

pub_date

1994-11-16 00:00:00

pages

117-9

issue

1

eissn

0166-4328

issn

1872-7549

pii

0166-4328(94)90080-9

journal_volume

65

pub_type

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