Abstract：
:About 99% of the unique genes and almost half of the cells found in the human body come from microbes including bacteria, archaea, fungi, and viruses. Collectively these microorganisms contribute to the microbiome and often reside in the gut. The gut microbiome plays an important role in the body and contributes to digestive health, the immune system, and brain function. The gut microbiome interacts with the central nervous system through the vagal pathways as well as the endocrine or immune pathways. Changes in the proportion or diversity of the microbiota can have an impact on normal physiology and has been implicated in inflammation, depression, obesity, and addiction. Several animal studies suggest the involvement of gut microbiome in the regulation of pain, emotion, and cognition. Alcoholism has been linked with gut microbiome dysbiosis and thus can have deleterious effects on the gut-brain axis balance. Gut microbiome produces important metabolites such as gastrointestinal hormones, short chain fatty acids, precursors to the neuroactive compounds and neurotransmitters that impact the physiology and normal functioning of the body. The microbiome imbalance has been correlated with behavioral changes and alcohol dependence in the host. The objective of this study is to elucidate the link between alcohol induced gut microbiota dysbiosis and any behavioral impact that could incur. A thorough literature search of various databases was conducted to gather data for the alcohol prompted gut microbiome dysbiosis. Ingenuity Pathway Analysis (IPA1) software was then utilized to identify links between alcoholism, gut microbiome derived metabolites, and their role in behavior alterations. Overall, this meta-analysis reviews information available on the connection between alcohol induced gut microbiome dysbiosis and the resulting behavioral impact.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Qamar N,Castano D,Patt C,Chu T,Cottrell J,Chang SLdoi
10.1016/j.bbr.2019.112196subject
Has Abstractpub_date
2019-12-30 00:00:00pages
112196eissn
0166-4328issn
1872-7549pii
S0166-4328(19)31164-7journal_volume
376pub_type
杂志文章,meta分析,评审abstract：:The object recognition task is a commonly used test for the assessment of memory functions in rodents. In this paper different aspects concerning the analysis of object recognition data are discussed. Using a set of experimental studies and fictive data sets, it was shown that the absolute discrimination measure (d1) ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.03.024
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abstract：:The study examined the effect of testosterone on the asymmetry of visual discrimination performance of young chicks. Two-week-old chicks were tested on the pebble floor visual discrimination task. Male chicks were found to have brain asymmetry for visual discrimination learning, since chicks tested binocularly, or tes...
journal_title：Behavioural brain research
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.05.008
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00302-8
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90105-n
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.07.007
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pub_type： 杂志文章
doi：10.1016/j.bbr.2014.09.041
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00184-4
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00228-6
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journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Behavioural brain research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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