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Pavlovian conditioning of immune function: animal investigation and the challenge of human application.

Abstract：

:Pavlovian conditioning of immune functions provided early impetus to the rapidly expanding knowledge of bi-directional communication among the immune, endocrine, and central nervous systems. Since these early investigations, the phenomenology of this response has been well characterized. However the neural mechanisms and biological relevance of conditioned immunomodulation remain unclear. To this end, we present here data from our laboratories that have: (1) revealed some of the neural mechanisms and biological relevance of an animal model of conditioned immunomodulation; (2) demonstrated the conditionability and potential mechanisms of conditioned immune responses in healthy humans, and (3) investigated conditioned immunomodulation in a clinical sample. Together, these data demonstrate that animal models provide a basis for investigating mechanisms whereby conditioned changes in immune function may modulate health status in a clinical realm.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Exton MS,von Auer AK,Buske-Kirschbaum A,Stockhorst U,Göbel U,Schedlowski M

doi

10.1016/s0166-4328(99)00191-6

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

129-41

issue

1-2

eissn

0166-4328

issn

1872-7549

pii

S0166432899001916

journal_volume

110

pub_type

杂志文章,评审

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