Abstract：
OBJECTIVE:Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The present study was designed to examine whether early cognitive alterations by dizocilpine (MK-801) in adolescence can impact the effect of EE on spatial memory, METH self-administration (SA), and cue-induced renewal in adulthood. METHODS:In Experiments 1 and 2, Morris Water Maze (MWM) performance, c-Fos expression and N-methyl d-aspartate receptor subtype 2B (NMDAR2B) levels were determined in various brain regions following a change in rearing condition from EE to an isolation environment (IE) at different points (PD 41-60 or PD 51-70). In Experiments 3 and 4, MWM performance and METH SA behaviors in adulthood were tested following adolescent administration of MK-801 during different periods of adolescence (PD 41-60 or PD 51-70) under EE rearing conditions. RESULTS:The early introduction of the IE at PD 41-60 significantly decreased the beneficial effect of EE on MWM performance in adulthood as compared to IE exposure at PD 51-70. Different rearing conditions also altered c-Fos expression and NMDA2B receptor activity in a regionally specific pattern. EE induced structural and systemic changes in the hippocampus that were associated with improvements in spatial memory. Early administration of MK-801 at PD 41-60 and PD 51-70 produced distinctive effects on the behavioral outcomes of METH SA and cue-induced renewal. CONCLUSION:Early cognitive alterations have a profound impact on spatial memory and METH dependence.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Zhang P,Pan J,Mao Z,Xu X,Lin D,Wu B,Zhou W,Liu Ydoi
10.1016/j.bbr.2019.01.032subject
Has Abstractpub_date
2019-05-02 00:00:00pages
83-93eissn
0166-4328issn
1872-7549pii
S0166-4328(18)31227-0journal_volume
363pub_type
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