Abstract：
:In the rat, brain growth is most vulnerable to undernutrition during the suckling period. Undernutrition at that stage also produces lasting effects on behaviour and it is often assumed that these are due to disturbances of brain growth. The proposal that this may not necessarily be so was explored by testing the behaviour of rats which had been undernourished at later stages of life and which, therefore, would be expected to show little or no deficit in brain growth. Rats were undernourished either immediately after weaning (25-67 days) or in adulthood (80-134 days) and were tested 3-4 months later on variable interval and variable ratio schedules of reinforcement with food as the reward. Their behaviour on these schedules was similar to that of rats undernourished during the suckling period: both groups responded or tended to respond at a higher rate than controls. Hence, it is possible that undernutrition at any stage in life may make animals more responsive to food when deprived subsequently. A cognitive mechanism for this change in behaviour is suggested.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Roberts HJ,Wearden JH,Smart JLdoi
10.1016/0166-4328(83)90035-9subject
Has Abstractpub_date
1983-12-01 00:00:00pages
287-96issue
2-3eissn
0166-4328issn
1872-7549pii
0166-4328(83)90035-9journal_volume
10pub_type
杂志文章abstract：:Chemotherapy related cognitive impairment (CTRC; "chemobrain") is a syndrome that is associated with the impairment of various aspects of cognition, including executive function, processing speed, and multitasking. The role of neurotransmitter release in the expression of cognitive impairments is not well known. In th...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.01.007
更新日期：2019-04-19 00:00:00
abstract：:Gender differences in spatial navigation have been widely reported in nocturnal rodent species. Here, for the first time we report gender differences in spatial learning and memory of Octodon degus, a long-lived diurnal hystricomorph rodent. In the present study, 16 months old male and female O. degus were tested in t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.005
更新日期：2010-10-15 00:00:00
abstract：:Rats with lesions in the perirhinal cortex and their control group learnt to discriminate between mirror-imaged visual landmarks to find a submerged platform in a watermaze. Rats initially learnt this discrimination passively, in that they were repeatedly placed on the platform in one corner of a square watermaze with...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.07.031
更新日期：2016-10-15 00:00:00
abstract：:The senescence-accelerated mouse (SAMP8) is a useful murine model of accelerated aging and learning deficiency. We examined bindings of [3H]pirenzepine, [3H]dizocilpine (MK-801), [3H]flunitrazepam, [3H]8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and [3H]phorbol 12,13-dibutylate (PDBu) in SAMP8 brains, and comp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)86045-7
更新日期：1997-02-01 00:00:00
abstract：:The effects of N-methyl-D-aspartate NMDA receptor antagonists on scopolamine-induced amnesia and on delay-interposed short-term memory performance were investigated using an 8-arm radial maze in rats. Scopolamine, a muscarinic antagonist, deteriorated the radial maze performance, while MK-801, an NMDA receptor channel...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)86075-5
更新日期：1997-02-01 00:00:00
abstract：:The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasega...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00029-7
更新日期：1999-08-01 00:00:00
abstract：:We developed a method to quantify the probability of a target neuron discharge following synchronous or asynchronous discharges among a pair of reference neurons. To illustrate this method, we simultaneously recorded three neurons having overlapping receptive fields in the somatosensory system: two reference neurons i...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00165-1
更新日期：2002-09-20 00:00:00
abstract：:Drug addiction is a chronic disorder characterized by a relatively high rate of relapse even after long period of abstinence. In the present study, we used the conditioned place preference (CPP) paradigm to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place condi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.03.042
更新日期：2009-09-14 00:00:00
abstract：:In humans, the Simon effect refers to the fact that choice reaction time (RT) is shorter when the stimulus corresponds spatially to the response than when it does not, albeit the location of the stimulus is irrelevant to the task. This effect has motivated innumerable empirical and theoretical studies and is considere...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.01.012
更新日期：2007-04-16 00:00:00
abstract：:Strategic processing allows for value-based preferential encoding of information. Event-related spectral perturbations can provide insights into neural processes linked to the different aspects of strategic processing. This study examined theta and alpha band power differences linked to processing of high- versus low-...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.03.052
更新日期：2019-07-23 00:00:00
abstract：:Cholinergic dysfunction and deposition of plaques containing amyloid β-peptides (Aβ) are two of the characteristics of Alzheimer's disease. Here, we combine APPswe/PS1dE9 (APP/PS1) mice with the cholinergic immunotoxin mu p75-saporin (SAP) to integrate partial basal forebrain cholinergic degeneration and the neuropath...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.11.012
更新日期：2013-03-01 00:00:00
abstract：:Mildronate (3-(2,2,2-trimethylhydrazinium) propionate) is an inhibitor of l-carnitine biosynthesis and an anti-ischemic drug. In the present study, we investigated the effects of mildronate in rats following focal cerebral ischemia. Male Wistar rats were subjected to transient occlusion of the middle cerebral artery (...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.03.027
更新日期：2011-09-12 00:00:00
abstract：:The median raphe nucleus (MR) has been shown to exert a powerful influence on behavioral arousal and marked locomotor hyperactivity can be produced by intra-MR injections of a variety of drugs including GABAA and GABAB agonists, excitatory amino acid antagonists, and μ- and δ-opioid agonists. Other studies have indica...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.12.004
更新日期：2014-03-15 00:00:00
abstract：:The phenomenon of dissociated memory retrieval is observed when some influences (for example, pharmacological) on the brain result in specific changes of long-term memory. The purpose of present paper is to reveal possibilities of the phenomenon for study of long-term memory retrieval. Pharmacologically-induced dissoc...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00090-x
更新日期：1999-12-01 00:00:00
abstract：:We examined four different learning and memory tasks in rats which had been subjected to left carotid artery ligation followed by 2 h hypoxia (8% oxygen) when they were 7 days old. The examination began on the 4th week after insult and continued to 18 weeks post-insult. Compared with the control group, the hypoxic-isc...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00287-4
更新日期：2001-01-08 00:00:00
abstract：:The objective of the present study was to evaluate whether maternal hyperleptinaemia programs anxiety-like and novelty-seeking behaviors as well as short-term memory/learning in adult male Wistar rats. During the first 10 days of lactation dams were s.c. injected with either murine leptin (LEP) or saline (CON). Adult ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.08.029
更新日期：2010-01-05 00:00:00
abstract：:In the present study, the involvement of dopamine D1 and D2 receptors in the dorsal globus pallidus (GP) in motor control was investigated in rats. Results show that bilateral microinfusions of the dopamine D1 receptor antagonist SCH23390 or the dopamine D2 antagonist S( - )-sulpiride into the GP induced akinesia dete...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00102-3
更新日期：1999-12-01 00:00:00
abstract：:Morphine, commonly used to relieve the acute or chronic pain, has a high potential for addiction and exerts rewarding effects via a critical role for mesolimbic dopamine system. Studies suggest that addiction-related behavior is highly associated with inflammatory immune response, but the mechanisms are poorly underst...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.08.022
更新日期：2017-09-29 00:00:00
abstract：:Epilepsy is a relatively common and chronic neurological condition, affecting 1-2% of the population. However, understanding of the underlying pathophysiology remains incomplete. To identify potential factors in the early environment that may increase the risk for experiencing seizures, maternal stress and environment...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.10.037
更新日期：2014-02-01 00:00:00
abstract：:The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We investigated the effect of prenata...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.022
更新日期：2014-11-01 00:00:00
abstract：:This experiment compared the shortcut choices of able-bodied teenagers with those of physically disabled teenagers who had varying histories of mobility impairment. In a computer-simulated kite-shaped maze, participants were allowed to explore three arms that connected four rooms. Subsequently they were offered a choi...
journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
doi：10.1016/s0166-4328(02)00097-9
更新日期：2002-10-17 00:00:00
abstract：:Light can elicit both circadian and acute physiological responses in humans. In a dose response protocol men and women were exposed to illuminances ranging from 3 to 9100 lux for 6.5 h during the early biological night after they had been exposed to <3 lux for several hours. Light exerted an acute alerting response as...
journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
doi：10.1016/s0166-4328(00)00236-9
更新日期：2000-10-01 00:00:00
abstract：:Despite extensive research on the relationship between acute stress and hippocampal function in adults, little is known about the short- and long-term effects of prolonged juvenile stress on learning, memory, and other hippocampal functions. This experiment investigated whether spatial learning would be altered in juv...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00315-1
更新日期：2002-01-22 00:00:00
abstract：:The effect of exogenous melatonin (MEL) on the circadian system in nocturnal species has been extensively studied, but little is known about its chronobiotic effect in diurnal mammals. The present study investigated the effect of exogenous MEL on the circadian locomotor activity rhythm in the diurnal rodent Arvicanthi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00411-9
更新日期：2002-06-15 00:00:00
abstract：:Hormonally induced mood disorders such as premenstrual dysphoric disorder (PMDD) are characterized by a range of physical and affective symptoms including anxiety, irritability, anhedonia, social withdrawal and depression. Studies demonstrated rodent models of progesterone withdrawal (PWD) have a high level of constru...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.09.002
更新日期：2013-11-01 00:00:00
abstract：:The basic functional organization of gerbil auditory cortex was previously mapped with unit recording of best frequency and with the fluoro-2-deoxyglucose mapping (FDG) technique. Among at least seven subfields in this cortex the primary auditory cortex (AI) and the anterior auditory field (AAF) showed prominent tonot...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)00140-b
更新日期：1995-01-23 00:00:00
abstract：:In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspects of avers...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)90153-8
更新日期：1994-04-18 00:00:00
abstract：:Sensory-motor development begins early during embryogenesis and is influenced by sensory experience. Little is known about the prenatal factors that influence the development of motor coordination. Here we investigated whether and to what extent prenatal light experience can influence the development of motor coordina...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.03.039
更新日期：2017-06-01 00:00:00
abstract：:Evidence from experimental animal studies convincingly argues for a role of pro-inflammatory cytokines due to surgical trauma in causing postoperative cognitive dysfunction. However, other studies have shown exposure to 2-4h of isoflurane anesthetic without surgical trauma can also impair cognitive function. We aimed ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.01.032
更新日期：2016-04-15 00:00:00
abstract：:Physiological effects of different types, of continuous and interval aerobic training, have been largely described and studied in the adult man. It was previously indicated that interval training plays an important role in maximizing both peripheral muscle and central cardiorespiratory adaptations, permitting signific...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.05.058
更新日期：2017-08-14 00:00:00
