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Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats.

Abstract：

:The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasegawa T, Furukawa H, Nabeshima T. Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats. Eur J Pharmacol 1996;318:7-9). The blockade of serotonin2A (5-HT2A) receptors using the antagonist ritanserin (3 and 10 mg/kg, p.o.) significantly attenuated this aversive property of PCP whereas lesions of serotonergic neurons using 5,7-dihydroxytryptamine (5,7-DHT, 100 microg/animal, i.c.v.) failed to affect it. Repeated PCP treatment (10 mg/kg, i.p. for 14 days), which is enough to diminish the stereotyped 5-HT2A receptor-mediated head-twitch behavior, also decreased the place aversion. These results suggest that the serotonergic neuronal system, specifically the 5-HT2A receptor, may play a critical role in producing PCP-induced place aversion.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Kitaichi K,Noda Y,Miyamoto Y,Numaguchi A,Osawa H,Hasegawa T,Furukawa H,Nabeshima T

doi

10.1016/s0166-4328(99)00029-7

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

105-11

issue

1

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(99)00029-7

journal_volume

103

pub_type

杂志文章

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