Abstract：
:The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviours in laboratory rats. The aim of the present study was to examine the effects of chronic stress on cognitive performance. About 70% of rats exposed to 7 weeks of chronic mild stress showed a gradual reduction in consumption of a sucrose solution, indicating an anhedonic-like state. The remaining rats did not reduce their sucrose intake, but appeared resilient to the stress-induced effects on sucrose intake. Cognitive profiling of the CMS rats revealed that chronic stress had a negative effect on performance in the spontaneous alternation test, possibly reflecting a deficit in working memory. This effect was independent of whether the stressed rats were anhedonic-like or stress-resilient as measured by their sucrose intake. CMS did not influence performance in passive avoidance and auditory cued fear conditioning, however, in rats displaying an anhedonic-like profile, CMS increased freezing behaviour in contextual fear conditioning.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Henningsen K,Andreasen JT,Bouzinova EV,Jayatissa MN,Jensen MS,Redrobe JP,Wiborg Odoi
10.1016/j.bbr.2008.10.039subject
Has Abstractpub_date
2009-03-02 00:00:00pages
136-41issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00593-7journal_volume
198pub_type
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