Abstract:
:Bilateral intranigral infusions of three different peptide agonists were made in rats exposed to fluphenazine decanoate, 30 mg/kg/month (FLU) or vehicle (CON) for seven months. Oral movements were monitored repeatedly during the neuroleptic pretreatment period, as well as before the intranigral infusion and during a 90-min period postinfusion. The FLU group had an increased frequency of vacuous chewing movements (VCM) during the pretreatment period in comparison to controls. Intranigral infusion of the neurokinin-1 (NK1) receptor agonist, [Pro9]Substance P (2.5 nmol on each side), 5-7 weeks after the last FLU injection, caused a significant increase of VCM in both pretreatment groups, lasting 7 min after the infusion. The VCM response to [Pro9]Substance P in the FLU group was significantly higher than in the CON group. A NK2 agonist [Lys5, MeLeu9, Nle10]Neurokinin A(4-10) (2.5 nmol) failed to produce significant changes in oral activity. A Leu-enkephalin analogue [D-Ala2,D-Leu5]enkephalin (3.8 nmol) induced a massive biting behavior in both FLU and CON rats. Using VCM as a behavioral assay, an increased nigral sensitivity to a NK1 agonist is demonstrated in rats chronically exposed to neuroleptics. No corresponding alterations could be ascribed for the NK2 receptor agonist or the Leu-enkephalin analogue.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Liminga U,Gunne LMdoi
10.1016/0166-4328(93)90064-wsubject
Has Abstractpub_date
1993-10-21 00:00:00pages
93-9issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(93)90064-Wjournal_volume
57pub_type
杂志文章abstract::We describe a stereotaxic technique to transect the optic chiasm in the rat and present illustrative data on the interocular transfer of visual discrimination in chiasm-sectioned and chiasm-plus-forebrain commissure-sectioned animals. Applications of the technique are discussed. ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80069-5
更新日期:1991-05-15 00:00:00
abstract::Amotivation is a major symptom of several psychiatric disorders. However, which specific motivations are most affected in various illnesses is not well understood. In major depressive disorder (MDD), anecdotal evidence suggests the motivation to explore may be especially affected, but direct evidence from either patie...
journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2016.09.055
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abstract::One of the most established hypotheses of depression focuses on alteration of the serotonergic (5-HT) function. Recent evidence suggests that serotonergic involvement in depression may be modulated by the action of gamma-hydroxybutyric acid (GABA). Furthermore, altered GABAergic function is also evident in depressed p...
journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2007-07-19 00:00:00
abstract::The great majority of tobacco addiction begins during adolescence. More heavily addicted smokers begin smoking earlier, but differentiating the neurobehavioral impact of nicotine self-administration during adolescence from self-selection bias (whereby people more prone to heavy addiction also begin earlier) cannot be ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.08.005
更新日期:2011-12-01 00:00:00
abstract::Non-human primates have become one of the most important model animals for the investigation of brain diseases because they share a wide-range of genetics and social similarities with human beings. Naturally-evoked depression models in macaques may offer a full spectrum of similarity to human depression states, but th...
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abstract::Neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) have opposing effects on stress-associated and consummatory behaviors in rodents. Recent studies also suggest that both peptides influence ethanol intake. In the present study, the effects of administration of CRF and NPY into the lateral ventricle on ethan...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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更新日期:1995-01-23 00:00:00
abstract::Intensive Care Unit (ICU) or emergency care patients, exposed to traumatic events, are at increased risk for Post-Traumatic Stress Disorder (PTSD) development. Commonly used sedative/anesthetic agents can interfere with the mechanisms of memory formation, exacerbating or attenuating the memory for the traumatic event,...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(93)90116-8
更新日期:1993-06-30 00:00:00
abstract::Chronic administration of cocaine can cause pronounced and enduring cognitive alterations such as increases in impulsive choice. Chronic cocaine can also result in enhanced dopamine (DA) release in the nucleus accumbens (NAc) in response to reward-related cues. It is possible that this enhanced DA release in the NAc i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.01.001
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:1985-05-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00085-2
更新日期:2003-02-17 00:00:00
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journal_title:Behavioural brain research
pub_type: 临床试验,杂志文章
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更新日期:2002-07-18 00:00:00
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2007.07.027
更新日期:2007-12-11 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.08.006
更新日期:2009-12-28 00:00:00
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pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.03.010
更新日期:2005-07-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90029-0
更新日期:1988-08-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.12.019
更新日期:2010-04-02 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.111932
更新日期:2019-09-16 00:00:00
abstract::The water maze task has been developed to test spatial learning abilities in rats or mice, and is widely used. Though it has been reported before that numerous cognitive abilities are of importance for learning this task, poor performance is usually interpreted as an impairment of spatial memory formation. Previous in...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(98)00134-x
更新日期:1999-04-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
abstract::Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corri...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.02.030
更新日期:2007-05-16 00:00:00
abstract::Corticotropin-releasing factor (CRF) acts to promote stress-like physiological and behavioral responses and is mainly expressed in the paraventricular hypothalamic nucleus (PVN). Urocortin 1 (Ucn1) is also a ligand to CRF type 1 and 2 receptors that has been associated with the stress response. Ucn1 neurons are primar...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.06.014
更新日期:2014-09-01 00:00:00