Abstract：
:Motor performance declines with increasing age and it has been proposed that elder people might compensate for these deficits with increased cerebral activation. However, it is not known, whether increased activation - especially in motor areas of the contralateral and the ipsilateral cerebral hemisphere - might effectively contribute to motor performance or whether it is an ineffective way to counteract age related deficits in the motor system. We tested this question by mapping brain activation during performance of differentially demanding motor tasks in 18 young (mean 25.39 years) and 17 elderly (mean 66.65 years) healthy individuals. We tested a wide range of hand motor tasks from passive wrist movements, fist clenching at different frequencies, to a somatosensory-guided finger pinch task. In the elderly group functional activation was generally increased for all tasks with comparable motor performance for ipsilateral primary and secondary motor areas. The young group showed increased contralateral primary motor cortex activation for the more difficult somatosensory guided precision grip task. We correlated motor performance of the task with high difficulty and comparable performance with fMRI-activation. Elder participants showed a negative correlation for the ipsilateral supplementary motor area (SMA) and for the ipsilateral sensorimotor cortex (SM1). Young participants showed a positive correlation for contralateral SMA and SM1. Our data suggest an increased cerebral recruitment reflects an inefficient response to an age-related higher difficulty of task and is not an effective way to counteract age-related deficits in the motor system.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Loibl M,Beutling W,Kaza E,Lotze Mdoi
10.1016/j.bbr.2011.04.040subject
Has Abstractpub_date
2011-10-01 00:00:00pages
280-6issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00350-0journal_volume
223pub_type
杂志文章abstract：:During unilateral hand movements the activity of the contralateral primary motor cortex (cM1) is increased while the activity of the ipsilateral M1 (iM1) is decreased. A potential explanation for this asymmetric activity pattern is transcallosal cM1-to-iM1 inhibitory control. To test this hypothesis, we examined inter...
journal_title：Behavioural brain research
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pub_type： 杂志文章
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