Abstract:
:The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD). Glucagon-like peptide 1 (GLP-1) receptor agonists are being utilized as neuroprotectants in the treatment of various neurological disorders, including AD. We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice. Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment. Aβ1-42 deposition and synapse damage in the hippocampus was significantly alleviated. Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics. These findings suggest that exenatide, which has already been applied in clinical medicine, may be a promising agent for AD therapy via mitochondrial protection.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
An J,Zhou Y,Zhang M,Xie Y,Ke S,Liu L,Pan X,Chen Zdoi
10.1016/j.bbr.2019.111932subject
Has Abstractpub_date
2019-09-16 00:00:00pages
111932eissn
0166-4328issn
1872-7549pii
S0166-4328(19)30242-6journal_volume
370pub_type
杂志文章abstract::Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This re...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2017.07.039
更新日期:2018-10-15 00:00:00
abstract::This study assesses gender differences in spatial and non-spatial relational learning and memory in adult humans behaving freely in a real-world, open-field environment. In Experiment 1, we tested the use of proximal landmarks as conditional cues allowing subjects to predict the location of rewards hidden in one of tw...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.09.046
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abstract::Various studies suggest that some sleep functions, especially some slow wave sleep functions, are indispensable in mammals and related to brain regulation. It has been proposed that two of these functions are the adjustment of emotional balance and the processing of acquired emotional memories. During waking, the grad...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(95)00005-e
更新日期:1995-07-01 00:00:00
abstract::Neuronal activity was recorded in the hippocampal formation, the parahippocampal gyrus and medial inferotemporal cortex of monkeys performing memory tasks. In a modified delayed matching to sample task in which 2 sequentially presented stimuli were compared on each trial, a match condition required a right panel press...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90038-g
更新日期:1990-10-30 00:00:00
abstract::Within the Pavlovian conditioning framework, extinction is a procedure in which, after conditioning, the conditioned stimulus (CS) is repeatedly presented without the unconditioned stimulus (US). During this procedure the conditioned response (CR) is gradually attenuated. It has been suggested that extinction during t...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.009
更新日期:2014-11-01 00:00:00
abstract::Non-patterned photic stimulation of the eyes of human subjects was obtained by homogeneous illumination of the closed eyes. The subjects perceived a difference between the stimulation intensity of the left and of the right eye as a field of view consisting of a bright and a dark half, adjoined across an indeterminate ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(82)90020-1
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abstract::Previous studies showed that the repeated administration with a low dose of reserpine (RES) induces a gradual appearance of motor signs and cognitive deficits compatible with parkinsonism in rodents. Environmental stimulation has neuroprotective effects in animal models of neurodegenerative damage, including acutely i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.04.028
更新日期:2017-06-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.08.036
更新日期:2011-01-20 00:00:00
abstract::The median raphe nucleus (MR) has been shown to exert a powerful influence on behavioral arousal and marked locomotor hyperactivity can be produced by intra-MR injections of a variety of drugs including GABAA and GABAB agonists, excitatory amino acid antagonists, and μ- and δ-opioid agonists. Other studies have indica...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.12.004
更新日期:2014-03-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00142-3
更新日期:1998-06-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.12.005
更新日期:2011-05-16 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.08.021
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(93)90100-5
更新日期:1993-12-20 00:00:00
abstract:INTRODUCTION:Visuospatial neglect can occur in peripersonal and extrapersonal space. The dorsal visual pathway is hypothesized to be associated with peripersonal, and the ventral pathway with extrapersonal neglect. We aimed to evaluate neural substrates of peripersonal versus extrapersonal neglect, separately for egoce...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.06.010
更新日期:2019-01-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.11.008
更新日期:2006-04-03 00:00:00
abstract::Integrating research efforts using a cross-domain approach could redefine traditional constructs used in behavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not from functional isolation but from integration. Our research group has been examining the interface between cogniti...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2014.05.028
更新日期:2015-01-01 00:00:00
abstract::The effect of feeding behavior on other behaviors (swimming, crawling and shortening) was investigated in the leech, Hirudo medicinalis. The stimulus locations and intensities required to produce mechanically elicited behaviors were first determined in the non-feeding leech. Stimuli were delivered while the leech was ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00072-7
更新日期:1998-01-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2013.04.046
更新日期:2013-08-01 00:00:00
abstract::The association between morphine withdrawal and depressive-like symptoms is well documented, however, the role of dynorphin/κ opioid receptor system and the underlying neural substrates have not been fully understood. In the present study, we found that four weeks morphine abstinence after a chronic escalating morphin...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.05.053
更新日期:2015-09-15 00:00:00
abstract::In the hippocampus of freely moving rats, neurons have been recorded that fire predominantly when the animal travels through a particular area while exploring the environment (so-called 'place cells'). This study investigates if the neuronal firing characteristics of such cells are modulated by attention, expectation ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00422-9
更新日期:2003-06-16 00:00:00
abstract:RATIONALE:Addiction is characterized by inflexible drug consumption: unpleasant consequences are accepted. Rat studies with several drugs proved that long-term voluntary intake induced abstinence-outlasting excessive and inflexible consumption. OBJECTIVE:Establishing a long-term model of oral self-administration of ni...
journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2010.10.011
更新日期:2011-03-01 00:00:00
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2016.06.013
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2009.03.035
更新日期:2009-09-14 00:00:00
abstract::Brain nerve growth factor (NGF) was determined in two groups of aged rats: 'good' and 'poor' performers. The animals were selected out of a population of 40 aged rats (26-28 months old) trained in a spatial learning task. Animals performing well in the test had significantly higher NGF in the hippocampus when compared...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80134-2
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abstract::Until the second half of the 20th century, it was broadly accepted that most birds are microsmatic if not anosmic and unable to detect and use olfactory information. Exceptions were eventually conceded for species like procellariiforms, vultures or kiwis that detect their food at least in part based on olfactory signa...
journal_title:Behavioural brain research
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更新日期:2009-06-25 00:00:00
abstract::Neonatal capsaicin administration has previously been shown to increase the threshold for withdrawal and escape response to noxious thermal, chemical and mechanical stimuli. The reason for these effects is destruction of afferent C-fibers and associated reduction in central substance P levels. In contrast, neonatal ca...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(84)90150-5
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abstract::Previous studies on starling song had shown that different categories of songs are produced and discriminated. In the present study, both playback experiments in the field and electrophysiological recordings of single cells in field L (main central auditory area) were used in order to understand the perceptual bases o...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(00)00191-1
更新日期:2000-09-01 00:00:00
abstract::Physiological effects of different types, of continuous and interval aerobic training, have been largely described and studied in the adult man. It was previously indicated that interval training plays an important role in maximizing both peripheral muscle and central cardiorespiratory adaptations, permitting signific...
journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2017.05.058
更新日期:2017-08-14 00:00:00
abstract::Individual differences in coping response lie at the core of vulnerability to conditions like post-traumatic stress disorder (PTSD). Like humans, not all animals exposed to severe stress show lasting change in affect. Predator stress is a traumatic experience inducing long-lasting fear, but not in all rodents. Thus, i...
journal_title:Behavioural brain research
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更新日期:2009-12-28 00:00:00
abstract::The mediodorsal nucleus of the thalamus was lesioned in cats, which had learned a spatial delayed-alternation task. Lesions were carried out with kainic acid or ibotenic acid. From altogether 29 cats, 9 cats with bilateral and 6 cats with unilateral lesions of the mediodorsal nucleus together with a control group of 4...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(82)90004-3
更新日期:1982-03-01 00:00:00