Stress impairs performance in spatial water maze learning tasks.

Abstract:

:The water maze task has been developed to test spatial learning abilities in rats or mice, and is widely used. Though it has been reported before that numerous cognitive abilities are of importance for learning this task, poor performance is usually interpreted as an impairment of spatial memory formation. Previous investigations that tried to correlate long-term potentiation (LTP) of synaptic transmission with spatial learning abilities in rats reported that injection of drugs or specific gene deletions which blocked the expression of LTP correlated with learning impairments of spatial tasks in a water maze. Recent studies, however, have shown that pretraining enables these animals to learn such spatial tasks even though LTP was still found to be blocked. I investigated to what degree altered fear condition and stress perception could account for the impaired spatial learning when no pretraining is given. In a fear habituation task, unhandled rats preferred a dark over a well lit chamber more than handled animals did, but unhandled rats favoured the lit chamber more in an active avoidance task. They also performed poorly in a spatial water maze task compared with handled rats. Rats pretrained in a radial arm maze performed better in a water maze than non-pretrained rats. No difference between groups was found in a non-spatial water maze task. On the other hand, when pretrained in a water maze, rats performed only marginally better in a radial arm maze compared to non-pretrained animals. Since animals have to be handled to learn a radial arm maze, the difference in this task was not due to stress but most probably due to getting accustomed to the room dimensions prior to learning the spatial task. The results suggest that impaired learning of spatial tasks in the water maze can be due to increased stress and decreased fear conditioning without actually affecting spatial learning abilities. These results question the interpretations of the results of some previously published results of spatial water maze tasks.

journal_name

Behav Brain Res

authors

Hölscher C

doi

10.1016/s0166-4328(98)00134-x

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

225-35

issue

1-2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(98)00134-X

journal_volume

100

pub_type

杂志文章
  • Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase.

    abstract::We have found that protein malnutrition (PM) causes a significant impairment of memory-related behavior on the 15th and 20th day after the start of PM (5% casein) feeding in prepubertal mice but not in postpubertal mice, as measured by a passive-avoidance task. This impairment was almost completely reversed by merely ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.08.024

    authors: Nakagawasai O,Yamadera F,Sato S,Taniguchi R,Hiraga H,Arai Y,Murakami H,Mawatari K,Niijima F,Tan-No K,Tadano T

    更新日期:2006-02-15 00:00:00

  • Xenin-induced feeding suppression is not mediated through the activation of central extracellular signal-regulated kinase signaling in mice.

    abstract::Xenin is a gut hormone that reduces food intake by partly acting through the hypothalamus via neurotensin receptor 1 (Ntsr1). However, specific signaling pathways that mediate xenin-induced feeding suppression are not fully understood. Activation of Ntsr1 leads to the activation of the extracellular signal-regulated k...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.06.026

    authors: Kim ER,Lew PS,Spirkina A,Mizuno TM

    更新日期:2016-10-01 00:00:00

  • Transient early postnatal corticosterone treatment of rats leads to accelerated aquisition of a spatial radial maze task and morphological changes in the septohippocampal region.

    abstract::In the present study new-born rats were treated with corticosterone (CORT) between postnatal days 1 and 12. At the age of 16-20 weeks, these animals were tested for spatial learning capacity using an eight-arm radial maze. After behavioral testing, density of cholinergic fibers and sizes of the mossy fiber terminal fi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.06.007

    authors: Roskoden T,Linke R,Schwegler H

    更新日期:2005-02-10 00:00:00

  • Unit activity in the medial septum during differential appetitive conditioning.

    abstract::Unit activity in the medial septal area of the rat was studied during pavlovian appetitive differential conditioning. The firing pattern of cells in the medial septum is that of suppression to presentation of the conditioned excitor and no significant increase to the presentation of the conditioned inhibitor. This pat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(89)80017-8

    authors: Yadin E

    更新日期:1989-05-01 00:00:00

  • Stress-induced changes in c-Fos and corticotropin releasing hormone immunoreactivity in the amygdala of the spontaneously hypertensive rat.

    abstract::The present study was undertaken to test the hypothesis that dysregulation of the amygdala contributes to the exaggerated autonomic response to stress in an animal model of essential hypertension. Spontaneously hypertensive (SHR) and normotensive Wistar male rats were chronically instrumented and exposed to 20 min of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.08.036

    authors: Porter K,Hayward LF

    更新日期:2011-01-20 00:00:00

  • Reversible inactivation of the medial septal area impairs consolidation but not retrieval of passive avoidance learning in rats.

    abstract::Involvement of the medial septal area (MSA) in consolidation and retrieval of passive avoidance response (PAR) was investigated with functional suppression of this area by tetrodotoxin (TTX). Rats carrying a chronically implanted cannula aimed at the MSA were trained on a step-through passive avoidance task and receiv...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(96)00136-2

    authors: Rashidy-Pour A,Motaghed-Larijani Z,Bures J

    更新日期:1995-12-14 00:00:00

  • Different role of cholecystokinin (CCK)-A and CCK-B receptors in relapse to morphine dependence in rats.

    abstract::The possible effect of different cholecystokinin (CCK) receptor antagonists (MK-329 and L-365260) on the maintenance and reactivation of morphine conditioned place preference (CPP) were investigated in rats, respectively. The results show that the maintenance of morphine CPP could be induced by injection of morphine (...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00361-2

    authors: Lu L,Huang M,Ma L,Li J

    更新日期:2001-04-08 00:00:00

  • Limbic system activation is affected by prenatal predator exposure and postnatal environmental enrichment and further moderated by dam and sex.

    abstract::Epilepsy is a relatively common and chronic neurological condition, affecting 1-2% of the population. However, understanding of the underlying pathophysiology remains incomplete. To identify potential factors in the early environment that may increase the risk for experiencing seizures, maternal stress and environment...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.10.037

    authors: Korgan AC,Green AD,Perrot TS,Esser MJ

    更新日期:2014-02-01 00:00:00

  • Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

    abstract::Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further im...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.04.046

    authors: Kesby JP,Fields JA,Chang A,Coban H,Achim CL,Semenova S,TMARC Group.

    更新日期:2018-09-03 00:00:00

  • Effects of maternal hyperleptinaemia during lactation on short-term memory/learning, anxiety-like and novelty-seeking behavioral traits of adult male rats.

    abstract::The objective of the present study was to evaluate whether maternal hyperleptinaemia programs anxiety-like and novelty-seeking behaviors as well as short-term memory/learning in adult male Wistar rats. During the first 10 days of lactation dams were s.c. injected with either murine leptin (LEP) or saline (CON). Adult ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.08.029

    authors: Fraga-Marques MC,Moura EG,Silva JO,Claudio-Neto S,Pereira-Toste F,Passos MC,Lisboa PC,Manhães AC

    更新日期:2010-01-05 00:00:00

  • Potential antidepressant and resilience mechanism revealed by metabolomic study on peripheral blood mononuclear cells of stress resilient rats.

    abstract::Resilience is an active coping response to stress, which plays a very important role in major depressive disorder study. The molecular mechanisms underlying such resilience are poorly understood. Peripheral blood mononuclear cells (PBMCs) were promising objects in unveiling the underlying pathogenesis of resilience. H...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.11.035

    authors: Li J,Zhang SX,Wang W,Cheng K,Guo H,Rao CL,Yang DY,He Y,Zou DZ,Han Y,Zhao LB,Li PF,Xie P

    更新日期:2017-03-01 00:00:00

  • Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?

    abstract::Stress during pregnancy is associated with lifetime negative consequences for the offspring. The present study examined the effects of prenatal stress on symptoms of illness following an immune challenge in mice. Additionally, this study examined whether pretreatment with fluoxetine (FLX) could prevent the effects of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.09.021

    authors: Avitsur R

    更新日期:2017-01-15 00:00:00

  • Contributions of the basal ganglia and functionally related brain structures to motor learning.

    abstract::This review discusses the cerebral plasticity, and the role of the cortico-striatal system in particular, observed as one is learning or planning to execute a newly learned motor behavior up to when the skill is consolidated or has become highly automatized. A special emphasis is given to imaging work describing the n...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2008.11.012

    authors: Doyon J,Bellec P,Amsel R,Penhune V,Monchi O,Carrier J,Lehéricy S,Benali H

    更新日期:2009-04-12 00:00:00

  • Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study.

    abstract::The aim of study was to search for new biomarkers with a magnetic resonance technique to identify the early stages of dementia, induced by D-galactose, and evaluate Simvastatin therapy. Localized proton magnetic resonance spectroscopy measurements showed a significant decrease in the concentration of N-acetylaspartate...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.02.016

    authors: Tušková R,Lipták B,Szomolányi P,Vančová O,Uličná O,Sumbalová Z,Kucharská J,Dubovický M,Trattnig S,Liptaj T,Kašparová S

    更新日期:2015-05-01 00:00:00

  • Pragmatic and idiosyncratic acts in human everyday routines: the counterpart of compulsive rituals.

    abstract::Our daily activities are comprised of motor routines, which are behavioral templates with specific goals, typically performed in an automatic fixed manner and without much conscious attention. Such routines can seem to resemble pathologic rituals that dominate the motor behavior of obsessive-compulsive disorder (OCD) ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.03.051

    authors: Keren H,Boyer P,Mort J,Eilam D

    更新日期:2010-09-01 00:00:00

  • Away game or home match: the influence of venue and serotonin transporter genotype on the display of offensive aggression.

    abstract::Aggression can be modulated by both genetic and environmental factors. Here, we analyse how the serotonin transporter (5-HTT) genotype and the environmental situation in which a contest takes place shape the display of offensive aggression. Therefore, male wildtype, heterozygous, and homozygous 5-HTT knockout mice, wh...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.01.029

    authors: Jansen F,Heiming RS,Kloke V,Kaiser S,Palme R,Lesch KP,Sachser N

    更新日期:2011-06-01 00:00:00

  • Chemical stimulation or glutamate injections in the nucleus of solitary tract enhance conditioned taste aversion.

    abstract::Taste memory depends on motivational and post-ingestional consequences after a single taste-illness pairing. During conditioned taste aversion (CTA), the taste and visceral pathways reach the nucleus of the solitary tract (NTS), which is the first relay in the CNS and has a vital function in receiving vagal chemical s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.09.023

    authors: García-Medina NE,Vera G,Miranda MI

    更新日期:2015-02-01 00:00:00

  • GABAergic nigro-collicular pathways modulate the defensive behaviour elicited by midbrain tectum stimulation.

    abstract::Midbrain tectum (MT) structures such as the dorsal periaqueductal gray matter and deep layers of superior colliculus are well-known for the organization and generation of defensive behaviour. Electrical stimulation or microinjection of GABA antagonists into these structures produce aversive behaviour. In order to dete...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90159-n

    authors: Coimbra NC,Brandão ML

    更新日期:1993-12-31 00:00:00

  • The effects of Ginkgo biloba extract on cognitive functions in aged female rats: the role of oxidative stress and brain-derived neurotrophic factor.

    abstract::The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehic...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.10.032

    authors: Belviranlı M,Okudan N

    更新日期:2015-02-01 00:00:00

  • D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI.

    abstract::Both the serotonin and glutamate systems have been implicated in the pathophysiology of schizophrenia, as well as in the mechanism of action of antipsychotic drugs. Psychedelic drugs act through the serotonin 2A receptor (5-HT2AR), and elicit a head-twitch response (HTR) in mice, which directly correlates to 5-HT2AR a...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.11.022

    authors: Santini MA,Balu DT,Puhl MD,Hill-Smith TE,Berg AR,Lucki I,Mikkelsen JD,Coyle JT

    更新日期:2014-02-01 00:00:00

  • Human sex differences in solving a virtual navigation problem.

    abstract::The current study examined sex differences in initial and subsequent strategies in solving a navigational problem within a virtual reality environment. We tested 163 undergraduates on a virtual T-maze task that included probe trials designed to assess whether participants were responding using either a place or respon...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.04.037

    authors: Astur RS,Purton AJ,Zaniewski MJ,Cimadevilla J,Markus EJ

    更新日期:2016-07-15 00:00:00

  • Immune activation during mid-gestation disrupts sensorimotor gating in rat offspring.

    abstract::Maternal immune activation (MIA) is a newly developed animal model of schizophrenia. It has recently been reported that when MIA is induced with the cytokine inducer polyinosinic-polycytidilic acid (poly I:C) rats do not show deficits in prepulse inhibition (PPI), a test that is often considered a validity benchmark. ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.02.021

    authors: Wolff AR,Bilkey DK

    更新日期:2008-06-26 00:00:00

  • The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit.

    abstract::Memory deficits may develop from a variety of neuropathologies including Alzheimer's disease dementia. During neurodegenerative conditions there are contributory factors such as neuroinflammation and amyloidogenesis involved in memory impairment. In the present study, dual properties of S100A9 protein as a pro-inflamm...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.03.016

    authors: Gruden MA,Davydova TV,Wang C,Narkevich VB,Fomina VG,Kudrin VS,Morozova-Roche LA,Sewell RD

    更新日期:2016-06-01 00:00:00

  • Administration of N-acetylserotonin and melatonin alleviate chronic ketamine-induced behavioural phenotype accompanying BDNF-independent and dependent converging cytoprotective mechanisms in the hippocampus.

    abstract::Though growing evidence implicates both melatonin (MLT) and its immediate precursor N-acetylserotonin (NAS) in the regulation of hippocampal neurogenesis, their comparative mechanistic relationship with core behavioural correlates of psychiatric disorders is largely unknown. To address this issue, we investigated the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.10.027

    authors: Choudhury A,Singh S,Palit G,Shukla S,Ganguly S

    更新日期:2016-01-15 00:00:00

  • The long-term effects of cocaine use on cognitive functioning: A systematic critical review.

    abstract:BACKGROUND:The predominant view of chronic cocaine use maintains that it causes a broad range of cognitive deficits. However, concerns about the possibly deleterious impact of cocaine on cognitive functioning have yet to be thoroughly vetted. This review addresses the impact of cocaine use on such cognitive domains as ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2018.04.005

    authors: Frazer KM,Richards Q,Keith DR

    更新日期:2018-08-01 00:00:00

  • Remote ischemic post-conditioning improves neurological function by AQP4 down-regulation in astrocytes.

    abstract::Cerebral ischemia is a primary cause of human death and long-term disability. Previous studies have suggested that remote ischemic post-conditioning (RIPC) is a potential useful tool for cerebral ischemic treatment. However, the protective mechanism of RIPC is not very clear. This study verified the hypothesis that, i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2015.04.024

    authors: Li S,Hu X,Zhang M,Zhou F,Lin N,Xia Q,Zhou Y,Qi W,Zong Y,Yang H,Wang T

    更新日期:2015-08-01 00:00:00

  • Rats with constitutionally upregulated/downregulated platelet 5HT transporter: differences in anxiety-related behavior.

    abstract::Serotonin (5-hydroxytryptamine, 5HT) plays important roles in both embryonic development as a mediator of neurogenesis and in the mature brain as a neurotransmitter. Disturbances in serotonergic transmission have been indicated in several psychiatric disorders. In the search for the biological substrates of psychiatri...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.07.008

    authors: Hranilovic D,Cicin-Sain L,Bordukalo-Niksic T,Jernej B

    更新日期:2005-12-07 00:00:00

  • Development of an opioid self-administration assay to study drug seeking in zebrafish.

    abstract::The zebrafish (Danio rerio) has become an excellent tool to study mental health disorders, due to its physiological and genetic similarity to humans, ease of genetic manipulation, and feasibility of small molecule screening. Zebrafish have been shown to exhibit characteristics of addiction to drugs of abuse in non-con...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.08.001

    authors: Bossé GD,Peterson RT

    更新日期:2017-09-29 00:00:00

  • Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice.

    abstract::The present study has been designed to investigate the effect of amniotic fluid derived stem cells on focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice. Middle cerebral artery occlusion of 60 min followed by reperfusion for 7 days was employed in present study to produce ischaemia and re...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.05.028

    authors: Rehni AK,Singh N,Jaggi AS,Singh M

    更新日期:2007-10-01 00:00:00

  • Object recognition testing: statistical considerations.

    abstract::The object recognition task is a commonly used test for the assessment of memory functions in rodents. In this paper different aspects concerning the analysis of object recognition data are discussed. Using a set of experimental studies and fictive data sets, it was shown that the absolute discrimination measure (d1) ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.03.024

    authors: Akkerman S,Prickaerts J,Steinbusch HW,Blokland A

    更新日期:2012-07-01 00:00:00