Abstract：
:Opponent-process theory occupies an important place in drug conditioning because it accounts for conditioned drug effects which are opposite to those induced by the drug itself. It has not been established, however, whether there is an opponent-process component to stimulant drug induced conditioned effects. In the present study the unilateral 6-hydroxydopamine (6-OHDA) rat model was used to examine this issue. Two groups of Sprague-Dawley rats with equivalent 6-OHDA lesions were administered five apomorphine treatments (0.05 mg/kg s.c.) either paired or unpaired to a 10-min test chamber placement. Apomorphine induced vigorous contralateral rotation and suppressed all ipsilateral rotation. While the apomorphine-induced contralateral rotation response can be conditioned to the test environment cues, the critical test of opponent-process theory in the present study was whether the opposite response of ipsilateral rotation would also become conditioned as a latent opponent-process response to the exteroceptive test environment cues associated with the apomorphine drug state. The postacquisition saline test for conditioning showed that the paired group exhibited higher rates of contralateral and ipsilateral rotation compared to the unpaired group. In addition, when the animals were subsequently tested with the dopaminergic receptor antagonist, haloperidol (0.5 mg/kg), unexpectedly, contralateral rotation was enhanced in the paired group, whereas, ipsilateral rotation was suppressed in both groups. While these findings are, in part, compatible with an opponent-process mechanism, the data supported a simpler explanation; namely, the mechanism of differential habituation in the two groups due to a blocking effect of apomorphine on habituation selectively in the paired group.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Carey RJ,Damianopoulos ENdoi
10.1016/s0166-4328(05)80207-4subject
Has Abstractpub_date
1992-11-15 00:00:00pages
139-47issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(05)80207-4journal_volume
51pub_type
杂志文章abstract：:Rats were trained on a reinforced alternation paradigm using an elevated T-maze. After pre-surgical training subjects received either ibotenic acid (4 micrograms/0.4 microliter) or vehicle (pH 7.4, 0.4 microliter) bilaterally into the region of the nucleus basalis magnocellularis--an important source of neocortical ac...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.07.026
更新日期：2006-01-06 00:00:00
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更新日期：2011-09-12 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2000-07-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1993-06-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.06.004
更新日期：2005-10-14 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(85)90030-0
更新日期：1985-12-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00038-8
更新日期：1999-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2009-01-30 00:00:00
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更新日期：2013-06-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2015-01-15 00:00:00
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journal_title：Behavioural brain research
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更新日期：2014-03-15 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2013.09.027
更新日期：2013-11-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1992-04-10 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1980-10-01 00:00:00
abstract：:We trained 24 rats to perform an eight-arm radial maze task and then assigned them with a matching procedure to one of three treatments: sham surgery or lesions of the projection areas of the mediodorsal thalamic nucleus (MDn) in the medial wall (MW) or in both the MW and rhinal sulcal (RS) areas of frontal cortex. Af...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)02272-3
更新日期：1997-09-01 00:00:00
