Abstract：
:The role of the nucleus basalis magnocellularis (NBM) in learning and memory has been demonstrated in different learning paradigms such as conditioned taste aversion (CTA) and inhibitory avoidance (IA). This participation has been related to the cholinergic system, but recent studies have reported the potential role of other neurotransmitters such as GABA. The effects of acute intracerebral administration of the GABAergic antagonist bicuculline (0.05 microg) and the GABAergic agonist muscimol (0.05 microg) into the NBM of male Wistar rats were assessed in CTA and IA learning. In both learning tasks, the drug administration was performed before the acquisition. Taste aversion learning was not affected by the infusion of any of the drugs administered. IA acquisition was not affected by the administration of bicuculline or muscimol, requiring similar number of trials to reach the learning criterion. However, when the rats were tested 24 h later, those injected with bicuculline or muscimol showed an impairment of the IA learning. The present results support a role of the GABAergic system in the consolidation process of IA learning.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Morón I,Ramírez-Lugo L,Ballesteros MA,Gutiérrez R,Miranda MI,Gallo M,Bermúdez-Rattoni Fdoi
10.1016/s0166-4328(02)00056-6subject
Has Abstractpub_date
2002-08-21 00:00:00pages
425-31issue
1-2eissn
0166-4328issn
1872-7549pii
S0166432802000566journal_volume
134pub_type
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