Abstract：
:In humans, the Simon effect refers to the fact that choice reaction time (RT) is shorter when the stimulus corresponds spatially to the response than when it does not, albeit the location of the stimulus is irrelevant to the task. This effect has motivated innumerable empirical and theoretical studies and is considered to reflect elementary cognitive processes. We report an experiment demonstrating that rats also display a Simon effect, the dynamics of which--as assessed by factorial manipulations and RT distribution analyses--partly corresponds to those of the effect studied in human participants. The present results are consistent with the ideas that in rats, like in humans, (i) the information conveyed by the stimulus is processed via two parallel routes, one controlled and relatively slow, and one fast and automatic (dual-route architecture) and (ii) the dual-route processing is finished before the start of motor processes. The correspondence between these findings and those reported in humans open new perspectives for neurophysiological investigations of the dual-route architecture in an animal model routinely studied in neuroscience research.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Courtière A,Hardouin J,Burle B,Vidal F,Hasbroucq Tdoi
10.1016/j.bbr.2007.01.012subject
Has Abstractpub_date
2007-04-16 00:00:00pages
69-75issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(07)00030-7journal_volume
179pub_type
杂志文章abstract：:The area postrema (AP), a chemosensitive organ located in the fourth ventricle, has been shown to mediate the formation of a lithium-induced conditioned taste avoidance (CTA) in rats. The present experiments examined the role of the AP in the discrimination between two equimolar solutions of sodium chloride (NaCl) and...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)02279-1
更新日期：1997-08-01 00:00:00
abstract：:Early life stress leads to several effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life. This study used repeated neonatal separati...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.03.045
更新日期：2014-07-15 00:00:00
abstract：:Tissue plasminogen activator (tPA) is known to play physiologically and pathologically crucial roles in the central nervous system. However, it is still obscure whether it affects social behavior. We investigated social behavior and neuronal activation after social stimulation in tPA knockout (KO) mice. In a resident-...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.11.022
更新日期：2015-03-15 00:00:00
abstract：:Blind pointing (i.e. pointing to visual targets without seeing the pointing arm) was investigated in normal subjects in response to stepwise lateral tilts (20 degrees) of the body, head, and trunk. Blind pointing positions of the right index finger on the outer surface of a hemispherical screen were measured relative ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90140-4
更新日期：1988-09-15 00:00:00
abstract：:Neurons in the isthmo-optic nucleus (ION) of the avian midbrain receive input predominantly from the ipsilateral optic tectum and project to the contralateral retina. Therefore, lesion in the ION removes tectal efferent signals to the retina in birds. In the present study, we trained Japanese quail to reach a target s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.05.008
更新日期：2012-08-01 00:00:00
abstract：:Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPI...
journal_title：Behavioural brain research
pub_type： 杂志文章
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abstract：:Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion. Glucocorticoids act on Type I mineralocorticoid (MR) and Type II glucocorticoid receptors (GR) to modulate mood and endocrine responses. Successful antidepressant ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.08.045
更新日期：2018-01-15 00:00:00
abstract：:The incidence of stress and stress-related disorders with the transition to motherhood, such as postpartum depression, is estimated to be 20%. Selective serotonin reuptake inhibitor (SSRI) medications are currently the antidepressant of choice to treat maternal mood disorders. However, little is known about the effect...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.11.043
更新日期：2012-03-01 00:00:00
abstract：:The pro-inflammatory cytokine interleukin-1 (IL-1) has been implicated in both inflammatory processes and nociceptive neurotransmission. To further investigate the role of IL-1 in different pain states, gene-disrupted mice lacking both IL-1alpha and IL-1beta genes (IL-1alphabeta (-/-)) were characterized in inflammato...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2005.09.024
更新日期：2006-02-28 00:00:00
abstract：:Exposure to social stress increases the vulnerability of experimental animals to the rewarding effects of cocaine and it has been suggested that the glutamatergic system could be involved in these effects of stress. The aim of this work is to determine the role of N-methyl-d-aspartate (NMDA) glutamate receptors in the...
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pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.025
更新日期：2019-04-01 00:00:00
abstract：:Several electrophysiological studies found response differences to a given stimulus when it is repeated frequently as compared to when it occurs rarely in oddball sequences. Initially defined in acoustic perception, such difference also exists in the visual modality and is referred to as visual mismatch negativity (vM...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.03.001
更新日期：2018-07-16 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is thought to play a role in the pathogenesis of various neurodegenerative disorders. However, clinical trials with COX-2 inhibitors have yielded contradictory results. In the present study we investigated whether COX-2 plays a role in the behavioral and cognitive impairments seen in olfactory...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.07.007
更新日期：2012-10-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(93)90090-d
更新日期：1993-12-20 00:00:00
abstract：:New granule neurons are born in the dentate gyrus region of the hippocampus throughout life. Behavioral effects of slowing or stopping this ongoing neurogenesis are generally observed only in complex cognitive tasks involving high levels of cue or memory interference or in tests of emotion presented after stress expos...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112152
更新日期：2019-12-30 00:00:00
abstract：BACKGROUND & AIM:Overpressure blast-wave induced brain injury (OBI) and its long-term neurological outcome pose significant concerns for military personnel. Our aim is to investigate the mechanism of injury due to OBI. METHODS:Rats were divided into 3 groups: (1) Control, (2) OBI (exposed 30psi peak pressure, 2-2.5ms)...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.04.025
更新日期：2018-03-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(93)90066-y
更新日期：1993-10-21 00:00:00
abstract：:Receptors for gonadal steroids are present in an interconnected network of limbic nuclei. The existence of this network structure has important implications for how steroids control reproductive physiology and behavior. In 1986, Cottingham and Pfaff proposed that properties of a steroid-responsive neural network could...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(98)00063-1
更新日期：1999-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)90153-8
更新日期：1994-04-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.08.014
更新日期：2016-01-01 00:00:00
abstract：:Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This re...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2017.07.039
更新日期：2018-10-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90180-8
更新日期：1983-06-01 00:00:00
abstract：:Anxiety disorders are highly prevalent and often result in poor quality of life. Available anxiolytics show significant adverse effects as well as partial efficacy in a sizable part of patients. Innovative treatments with more favorable risk-benefit ratio are sorely needed. A growing body of clinical data indicates th...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.10.010
更新日期：2017-01-15 00:00:00
abstract：:Psychophysical procedures were used to investigate the effects observed by humans when two odorants were presented simultaneously through the same nostril (physical mixture) or separate nostrils (dichorhinic mixture). The odor pairs were (+)-limonene and alpha-pinene, (+)-limonene and propionic acid, alpha-pinene and ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(87)90157-4
更新日期：1987-11-01 00:00:00
abstract：:Cocaine-induced hyperactivity was inhibited by a single administration of naloxone (2 and 5 mg/kg, i.p.), an opioid receptor antagonist, and naloxone administered prior to and during the chronic injection of cocaine attenuated the development of both cocaine-induced reverse tolerance and conditioned place preference (...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)00162-3
更新日期：1997-04-01 00:00:00
abstract：:Expression levels of neuropeptide Y (NPY) are changed in schizophrenia patients. However, the direction of changes to NPY expression and the mechanisms behind NPY's impact on the development of the illness is not understood in detail. Here we investigated whether alterations in Y2 activity may be involved in the devel...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.10.029
更新日期：2010-03-05 00:00:00
abstract：:The exposure to stress has been associated with increased depressive and anxiety symptoms, yet not all individuals respond negatively to the experience of stress. Recent rodent social defeat models demonstrate similar individual differences in response to social stress. In particular, mice subjected to chronic social ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.09.009
更新日期：2013-11-01 00:00:00
abstract：:The 3xTg-AD mouse model of Alzheimer's disease (AD) has both amyloid beta plaque and tau tangle pathology. However, the results of behavioural testing with these mice have been inconsistent due to age- and sex-related differences, as well as differences in the difficulty of the tests used to measure cognitive function...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.111937
更新日期：2019-09-16 00:00:00
abstract：:Social impairments in autism remain poorly understood and without approved pharmacotherapies. Novel animals models are needed to elucidate mechanisms and evaluate novel treatments for the social deficits in autism. Recently, serotonin 1B receptor (5-HT1B) agonist challenge in mice was shown to induce autism-like behav...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.07.027
更新日期：2016-11-01 00:00:00
abstract：:Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways affected by chronic stress in brain have not been fully explored. We invest...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112053
更新日期：2019-10-17 00:00:00
abstract：:Reduced frequency of theta activity is thought to compromise hippocampal function and so behavioural inhibition. The anxiolytic benzodiazepine chlordiazepoxide (CDP) reduces theta frequency when injected into the medial supramammillary nucleus (mSuM), posterior hypothalamic nucleus (PH) and dorsomedial hypothalamic nu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.04.004
更新日期：2005-08-30 00:00:00
