Abstract：
:Reduced frequency of theta activity is thought to compromise hippocampal function and so behavioural inhibition. The anxiolytic benzodiazepine chlordiazepoxide (CDP) reduces theta frequency when injected into the medial supramammillary nucleus (mSuM), posterior hypothalamic nucleus (PH) and dorsomedial hypothalamic nucleus (DMH). These hypothalamic effects on theta could underlie at least some behavioural effects of benzodiazepines. We have previously shown that in a fixed interval 60-s schedule (FI60), CDP injected into mSuM reduced both theta frequency and behavioural inhibition. The present experiments test the effect of injections into PH and DMH on theta and hippocampal-sensitive behaviour (FI60 and open field ambulation). Systemic CDP (5mg/kg i.p.) released, but PH/CDP (20microg in 0.5microl vehicle) suppressed FI responding, though they both reduced FI theta frequency. In the open field, both CDP i.p. and PH/CDP reduced ambulation, but only the systemic injection reduced ambulation theta frequency. Taken together with previous research, these results support a role for PH in the control of voluntary behaviour. They imply that this function may be suppressed, independently of theta, by benzodiazepines. An anxiolytic effect of PH/CDP in FI60 may, therefore, have been masked by a concurrent action of CDP on the PH motor system. DMH/CDP did not affect behaviour or theta in either experiment, despite the fact that this nucleus is involved in benzodiazepine mediation of risk assessment and the flight response. This suggests that, like the control of theta frequency by the hypothalamus, the neural mechanisms underlying anxiety are distributed in complex networks.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Woodnorth MA,McNaughton Ndoi
10.1016/j.bbr.2005.04.004subject
Has Abstractpub_date
2005-08-30 00:00:00pages
107-14issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(05)00160-9journal_volume
163pub_type
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00029-7
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)90088-4
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更新日期：1980-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1992-03-15 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2009.03.015
更新日期：2009-08-24 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.11.025
更新日期：2014-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00213-1
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pub_type： 杂志文章
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更新日期：2017-05-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.06.007
更新日期：2018-10-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.10.050
更新日期：2012-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.09.055
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.03.039
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doi：10.1016/j.bbr.2015.05.048
更新日期：2015-10-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-01-05 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(85)90030-0
更新日期：1985-12-01 00:00:00
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更新日期：2017-08-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2015-01-15 00:00:00
abstract：:This report summarizes 4 experiments which deal with the effects of surgical removal of the rat's telencephalic forebrain structures on performance of an inhibitory avoidance response, which was acquired either before or after the lesion was made. Two experiments provide evidence that inhibitory avoidance learning (us...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(86)90036-7
更新日期：1986-11-01 00:00:00
abstract：:Severe temporal lobe epilepsy in humans is often associated with loss of neurons in the hippocampus and memory deficits. In Experiment 1, 60 min of continuous electrical stimulation of the perforant path sufficient to produce seizures resembling status epilepticus and loss of hilar and pyramidal cells in the hippocamp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00107-2
更新日期：2000-01-01 00:00:00
