Abstract:
:Rats with hippocampal aspiration lesions (HIPP), cortical control lesions (CORT) or sham operations (SHAM) were trained on a delayed alternation GO/NO-GO task, in which responding was reinforced on odd-numbered GO trials but was not reinforced on even-numbered NO-GO trials. The number of responses required to obtain reinforcement, and the length of the inter-trial intervals (ITIs), were varied in different stages of the experiment. These systematic parametric manipulations were conducted in order to compare the roles of intra- and inter-trial information and the temporal spans which could be bridged in performing the task across the three different lesion groups. In addition, at a later stage of testing interference was introduced during the ITI to investigate its effect on task performance. The differences observed between the HIPP, CORT and SHAM groups were generally non-specific for trial type, with HIPP animals responding more overall on both NO-GO and, to a lesser extent, GO trials following each of the ITIs used. The results were consistent with the behavioural inhibition theory of hippocampal function, but not with the temporal discontiguity or working memory models. These surprising findings contrast sharply with those observed following an electrolytic lesion of the hippocampus, which has been reported to produce a delay-dependent impairment of performance on the GO/NO-GO task in rats using a very similar procedure. It is speculated that differences in performance following aspiration and electrolytic lesions may be at least partially attributable to rats adopting different response strategies induced by ITI differences in the two tasks. However, the results also raise an important question concerning the assumed equivalence of aspiration and electrolytic lesions of the hippocampus. The possibility that an interaction between procedural and lesion differences may contribute to the discrepant findings is also considered. The findings illustrate the sensitivity of the hippocampal mnemonic effect on what has become an established testing procedure in the hippocampal literature.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Foster JK,Rawlins JNdoi
10.1016/s0166-4328(05)80250-5subject
Has Abstractpub_date
1992-03-15 00:00:00pages
35-48issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(05)80250-5journal_volume
47pub_type
杂志文章abstract::The spontaneously hypertensive rat (SHR) has been used as a genetic animal model of attention deficit/hyperactivity disorder (ADHD). SHR/Izm is derived from stroke-resistant SHR as SHR/NIH and SHR/NCrl but from 22nd to 23rd generation descendants of the SHR/NIH ancestor and therefore may show different behavioral phen...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.026
更新日期:2014-11-01 00:00:00
abstract::In this study we examined behavioral sleep in the walrus, the only living species of the family Odobenidae. The behavior of four 1.5-2-year-old captive walruses was videotaped continuously for 7-17 days and scored in 1-min epochs. When walruses had access to water and land, behavioral sleep, the combined amount of qui...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.01.033
更新日期:2009-07-19 00:00:00
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journal_title:Behavioural brain research
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doi:10.1016/0166-4328(93)90011-e
更新日期:1993-05-31 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00460-0
更新日期:2002-08-21 00:00:00
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2010.08.022
更新日期:2011-01-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-07-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(95)00005-e
更新日期:1995-07-01 00:00:00
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2013.10.037
更新日期:2014-02-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80096-8
更新日期:1991-12-13 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.09.009
更新日期:2011-01-20 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.05.029
更新日期:2011-10-31 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.02.011
更新日期:2009-07-19 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.bbr.2018.12.024
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.09.018
更新日期:2018-01-30 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.07.041
更新日期:2008-01-10 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.08.036
更新日期:2006-12-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.11.049
更新日期:2009-12-07 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2008.12.005
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00072-7
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(89)80102-0
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.02.041
更新日期:2013-06-15 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.06.009
更新日期:2010-12-25 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112782
更新日期:2020-09-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00190-3
更新日期:1998-05-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)00041-1
更新日期:1996-11-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.09.033
更新日期:2011-02-02 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.02.001
更新日期:2010-06-26 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.04.053
更新日期:2011-10-01 00:00:00