Abstract：
:Attention to addiction of women alone for fetus and infant's health has caused the possible role of father's status was less considered, while some developmental impairments including decrease of liter size, weight loss, congenital deficiencies, behavioral disorders, and learning and memory impairments in offspring with addicted father have been reported. In this study the effects of addiction of one or both parents to morphine on male and female offspring hippocampal long-term potentiation (LTP), were assessed. One hundred twenty female and 48 male rats (4-5 months, 250-270 g) were used. Forty females and 16 males were addicted by oral administration of morphine (32 mg/kg twice daily) for 5 days before mating. Then each two males with five females were housed (coupled) per cage as five groups for coupling: (A) addicted females+5% dextrose males (add.F); (B) addicted males+5% dextrose females (add.M); (C) addicted females+addicted males (add.MF); (D) 5% dextrose females+intact males (dex.F); (E) 5% dextrose males+intact females (dex.M). In puberty offspring LTP was induced in hippocampal dentate gyrus by stimulation of perforant path (pp). Changes of population spikes (PS) amplitude and LTP slope at 0, 5, 30, 60 and 120 min were evaluated. Slope of LTP at 30, 60 and 120 min, and amplitude of PS at 60 and 120 min in add.F and add.M offspring were significantly lower than dextrose groups (P<0.01). LTP slope and PS amplitude of male and female offspring did not different between add.F and add.M groups. Our results suggest that both parental and paternal addiction to morphine may cause memory deficiency through reduction of LTP in hippocampus.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Sarkaki A,Assaei R,Motamedi F,Badavi M,Pajouhi Ndoi
10.1016/j.bbr.2007.07.041subject
Has Abstractpub_date
2008-01-10 00:00:00pages
72-7issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(07)00391-9journal_volume
186pub_type
杂志文章abstract：:The ameliorating effects of the ethyl acetate fraction from Dendropanax morbifera (EFDM) on cognitive impairment in high-fat diet (HFD)-induced diabetic mice were examined by measuring its possible pharmacological activities. Administration of EFDM (20 and 50mg/kg body weight) in HFD-induced diabetic mice significantl...
journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.03.009
更新日期：2004-10-05 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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更新日期：2005-02-28 00:00:00
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journal_title：Behavioural brain research
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更新日期：2018-01-15 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2006.03.025
更新日期：2006-07-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2011.04.032
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2004-09-23 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2016-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：1987-03-01 00:00:00
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更新日期：2015-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.07.028
更新日期：2012-11-01 00:00:00
abstract：:Low dose of D-cycloserine (DCS), a partial agonist of glycine binding site on N-methyl-D-aspartate (NMDA) receptors, can facilitate extracellular signal-regulated kinase1/2 (ERK1/2) activity in the amygdala and modulate emotional behavior. However, the relationship between ERK1/2 activation, individual anxiety levels,...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.09.013
更新日期：2008-03-05 00:00:00
