当前位置： SCI文献检索 > BEHAVIOURAL BRAIN RESEARCH期刊下所有文献 > Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.

Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.

Abstract：

:Repeated systemic administration of low doses of kainic acid (KA) induces spontaneous convulsive seizures [Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 1998;31:73-84]. In this study, male Sprague-Dawley animals received intranigral transplants of a control cell line M213-2O, or a cell line transfected with human GAD67 cDNA (M213-2O CL4) [Conejero-Goldberg C, Tornatore C, Abi-Saab W, Monaco MC, Dillon-Carter O, Vawter M, et al. Transduction of human GAD67 cDNA into immortalized striatal cell lines using an Epstein-Barr virus-based plasmid vector increases GABA content. Exp Neurol 2000;161:453-61], or no transplant. Eight weeks after transplantation surgery, KA was administered (5 mg/kg/h) until animals reached stage V seizures as described by Racine [Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281-94]. The group transplanted with CL4 required a larger dose of KA and a longer latency to reach a stage V seizure. In addition, this group exhibited significantly fewer stage III and IV seizures. These results indicate that intranigral transplants of a GABA-producing cell line can decrease the number of kainic acid-induced seizures.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Castillo CG,Mendoza S,Freed WJ,Giordano M

doi

10.1016/j.bbr.2006.03.025

subject

Has Abstract

pub_date

2006-07-15 00:00:00

pages

109-15

issue

1

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(06)00182-3

journal_volume

171

pub_type

杂志文章

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