Abstract：
:Repeated administration of methamphetamine (mAMPH) to rodents in a single-day "binge" regimen damages forebrain monoaminergic nerve terminals and produces subsequent cognitive deficits. Here we investigate performance on a social odor-based task, demonstrating enduring mAMPH-induced deficits in recognition memory. Three weeks after a neurotoxic mAMPH regimen, singly-housed male Long-Evans rats had four wooden beads placed in their home cage: three beads containing odors from their home cage (HC beads) and one bead from a cage of a rat not present in the colony room (N1 bead). Exploration times for each bead were recorded during three 1-min habituation trials separated by 1-min intertrial intervals. Twenty-four hours later, a 1-min memory test was conducted, in which animals were presented with two HC beads, one N1 bead, and one bead from another novel animal (N2). Saline- and mAMPH-treated rats showed similar, progressive decreases in exploration time for the N1 bead during the habituation trials, indicating equivalent short-term olfactory habituation to the novel odor. By contrast, during the subsequent memory test, saline-treated rats showed a strong preference for the N2 bead over the N1 bead while mAMPH-treated rats showed no preference. The use of the rats' primary sensory modality (olfaction) coupled with the social significance (from conspecifics) of the odors produces strong, long-lasting memories. Our results show that prior treatment with a neurotoxic regimen of mAMPH impairs long-term memory for the previously experienced odors. As compared with previously employed object recognition tasks, this test may be advantageous for investigating mAMPH-induced memory impairments in rodents.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
O'Dell SJ,Feinberg LM,Marshall JFdoi
10.1016/j.bbr.2010.08.022subject
Has Abstractpub_date
2011-01-01 00:00:00pages
396-401issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00581-4journal_volume
216pub_type
杂志文章abstract：:Transcranial direct current stimulation (tDCS) modulates excitability of motor cortex. However, there is conflicting evidence about the efficacy of this non-invasive brain stimulation modality to modulate performance on cognitive tasks. Previous work has tested the effect of tDCS on specific facets of cognition and ex...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.04.031
更新日期：2015-09-01 00:00:00
abstract：:Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.08.024
更新日期：2016-01-01 00:00:00
abstract：:An approximation of the membrane resistance - input resistance - was measured with double-barrelled micropipettes in hindlimb motoneurons during wakefulness and the states of sleep in chronically implanted, restrained cats. During postural atonia in rapid-eye-movement (REM) sleep, motoneurons had a sustained hyperpola...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(81)90060-7
更新日期：1981-03-01 00:00:00
abstract：:The ventral medial prefrontal cortex (vmPFC) controls vulnerability to the negative effects of chronic or uncontrollable stress. Dominance status alters responses to social defeat in the conditioned defeat model, which is a model characterized by loss of territorial aggression and increased submissive and defensive be...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.01.006
更新日期：2013-04-15 00:00:00
abstract：:Tactile stimulation has been reported to be effective as a treatment for inducing growth in premature human babies and infant rats and for improving functional recovery after brain injury in infant rats. We wondered if the behavioral impairments following injury in adulthood would show similar improvements with tactil...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.008
更新日期：2010-12-06 00:00:00
abstract：:Physical exercise could be a protective factor against the development of substance use disorders; however, a number of preclinical studies report reward-enhancing effects of exercise for various drugs of abuse. We examined the effects of chronic wheel-running on brain reward sensitivity, reaction to novelty, reward-f...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112831
更新日期：2020-09-15 00:00:00
abstract：:Intraperitoneal (i.p.) administration of lithium chloride (LiCl) has two effects on pain sensation: (1) it induces a transient hyperalgesia that is reversed by intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of the opioid receptor antagonist naloxone or by peripheral administration of the quatern...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.08.022
更新日期：2004-05-05 00:00:00
abstract：:Rats were randomly assigned to enriched (EE) or standard environments (SE) at 21 or 73 days of age, for 17 days. Half of the rats of each rearing condition were trained in a radial maze (RM). At 38 days (pre-pubertal) or 90 days (young), rats were sacrificed and brain cytosolic and mitochondrial nitric oxide synthase ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.06.024
更新日期：2007-12-03 00:00:00
abstract：:Experience-dependent synaptic plasticity is widely expressed in the mammalian brain and is believed to underlie memory formation. Persistent forms of synaptic plasticity in the hippocampus, such as long-term potentiation (LTP) and long-term depression (LTD) are particularly of interest, as evidence is accumulating tha...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.01.022
更新日期：2015-05-15 00:00:00
abstract：:The mesolimbic reward pathway is implicated in stress-related psychiatric disorders and is a potential target of plasticity underlying the stress resistance produced by repeated voluntary exercise. It is unknown, however, whether rats find long-term access to running wheels rewarding, or if repeated voluntary exercise...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.11.005
更新日期：2011-03-01 00:00:00
abstract：:Stress during pregnancy is associated with lifetime negative consequences for the offspring. The present study examined the effects of prenatal stress on symptoms of illness following an immune challenge in mice. Additionally, this study examined whether pretreatment with fluoxetine (FLX) could prevent the effects of ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.09.021
更新日期：2017-01-15 00:00:00
abstract：:This is a review of our current knowledge about the role of the periaqueductal grey (PAG) in vocal control. It shows that electrical stimulation of the PAG can evoke species-specific calls with short latency and low habituation in many mammals. The vocalization-eliciting region contains neurones the activity of which ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)90017-5
更新日期：1994-06-30 00:00:00
abstract：:Monoamines such as norepinephrine (NE) and serotonin (5-HT) have shown to play an important role in motor recovery after brain injury. The effects elicited by these neurotransmitters have been reported as distal from the area directly affected. Remote changes may take place over minutes to weeks and play an important ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.10.009
更新日期：2016-01-15 00:00:00
abstract：:The concept of a rat-robot was initially introduced in 2002, bringing to the field, a novel area of research using modern research into neuroscience and robotics. This paper brings to the table, a study into the method best used for navigation systems in a rat-robot. Current research is epitomized by the use of reward...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.11.002
更新日期：2016-02-01 00:00:00
abstract：:Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder, which shares some clinical features with Autism spectrum disorder (ASD). The genetic factors relevant to the development of both disorders are yet to be fully understood, however, some genetic association studies have identified inner mitochondrial...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112057
更新日期：2019-11-18 00:00:00
abstract：:GABAB receptors are crucial modulators of the behavioural effects of drug abuse, and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of GABAB1 and GABAB2 subunits. The predominant neuronal GABAB1 subunit...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.10.039
更新日期：2016-02-01 00:00:00
abstract：:Mild traumatic brain injury is a common outcome of blast exposure, and current literature indicates high rates of comorbid posttraumatic stress disorder (PTSD) in military personnel. Blast-exposed rats display PTSD-like behavior, suggesting relationships may exist between PTSD and blast exposure. Other studies demonst...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.04.009
更新日期：2019-08-05 00:00:00
abstract：:Hedonic intake of strongly rewarding foods is independent from biological needs and, thus, a common cause of obesity. The effect of potato chips on energy intake in a snacking model could be explained by their fat/carbohydrate content (FCHc). The present study investigated if the FCHc shapes energy intake patterns and...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.02.041
更新日期：2019-05-17 00:00:00
abstract：:Recognizing and categorizing visual stimuli are cognitive functions vital for survival, and an important feature of visual systems in primates as well as in birds. Visual stimuli are processed along the ventral visual pathway. At every stage in the hierarchy, neurons respond selectively to more complex features, trans...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.05.014
更新日期：2019-01-01 00:00:00
abstract：:The pyramidal tract of the rat consists of at least two components. A majority of the fibers cross in the lower medulla and descend through the spinal cord in the ventral portion of the dorsal funiculus. The remaining 5% of the corticospinal projection does not cross and descends in the ipsilateral ventral funiculus i...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00051-7
更新日期：2002-08-21 00:00:00
abstract：:We trained 24 rats to perform an eight-arm radial maze task and then assigned them with a matching procedure to one of three treatments: sham surgery or lesions of the projection areas of the mediodorsal thalamic nucleus (MDn) in the medial wall (MW) or in both the MW and rhinal sulcal (RS) areas of frontal cortex. Af...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)02272-3
更新日期：1997-09-01 00:00:00
abstract：:Protein phosphorylation is a well-known and well-documented mechanism in memory processes. Although a large series of protein kinases involved in memory processes have been reported, information on phosphoproteins is limited. It was therefore the aim of the study to determine a partial and differential phosphoproteome...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.01.047
更新日期：2014-05-01 00:00:00
abstract：:Several electrophysiological studies found response differences to a given stimulus when it is repeated frequently as compared to when it occurs rarely in oddball sequences. Initially defined in acoustic perception, such difference also exists in the visual modality and is referred to as visual mismatch negativity (vM...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.03.001
更新日期：2018-07-16 00:00:00
abstract：:Individuals with trait anxiety are often considered to be predisposed to psychiatric disorders. However, there is great heterogeneity in the development of psychiatric disorders in this group of people and the nature of the trait anxiety is still unclear. So, we decided to explore the correlations of brain structure a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.06.036
更新日期：2016-10-01 00:00:00
abstract：:Visual evoked potentials (VEPs) were analyzed in order to distinguish between rats from genetically high (HI) and low (LO) self-stimulation lines (LC2-HI and LC2-LO). Secondary VEP components - slow secondary negative wave (SNW) and sensory afterdischarge (SAD) - which are considered to be most sensitive indices of no...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(84)90137-2
更新日期：1984-02-01 00:00:00
abstract：:Prepulse inhibition is modulated by dopaminergic drugs and is disrupted in attention-deficit hyperactivity disorder, as well as mental illnesses such as schizophrenia. Spontaneously hypertensive rats (SHR) have been proposed as an animal model of attention-deficit hyperactivity disorder and show marked alterations of ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.02.021
更新日期：2004-10-05 00:00:00
abstract：:The role of the olfactory inputs transmitted by the medial olfactory pathways --i.e. anterior limb of the anterior commissure and medial forebrain bundle-was studied in rats submitted either to a bilateral lesion of the anterior commissure (bAC group) or to a bilateral transection of the lateral olfactory tract follow...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(82)90017-1
更新日期：1982-12-01 00:00:00
abstract：:We have reported previously that exposure to the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) during the neonatal period causes cognitive impairments in adult rats. The aim of this study was to investigate the long-term effects of neonatal BMAA exposure on learning and memory mechanisms and to identify e...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.01.056
更新日期：2011-06-01 00:00:00
abstract：:In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspects of avers...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)90153-8
更新日期：1994-04-18 00:00:00
abstract：INTRODUCTION:Visuospatial neglect can occur in peripersonal and extrapersonal space. The dorsal visual pathway is hypothesized to be associated with peripersonal, and the ventral pathway with extrapersonal neglect. We aimed to evaluate neural substrates of peripersonal versus extrapersonal neglect, separately for egoce...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.06.010
更新日期：2019-01-01 00:00:00
