Abstract:
:Expression levels of neuropeptide Y (NPY) are changed in schizophrenia patients. However, the direction of changes to NPY expression and the mechanisms behind NPY's impact on the development of the illness is not understood in detail. Here we investigated whether alterations in Y2 activity may be involved in the development of schizophrenia-related behaviours. We examined NPY Y2 receptor deficient male mice in behavioural domains relevant for the illness: locomotion, learning and memory, social interaction and sensorimotor gating (baseline and after acute challenge with psychotropic drugs) and the most relevant tasks were also completed in female Y2 mutants. Our investigations confirmed a hyper-locomotive phenotype for Y2 deficient male mice and no alterations in working and reference memory performance. Mutant males exhibited an increase in social interaction and moderately improved sensorimotor gating. The psychotropic drugs dexamphetamine and MK-801 affected prepulse inhibition similarly, whereas MK-801 appeared to be a slightly more potent stimulant for the acoustic startle response (ASR). Female Y2 deficient mice showed wild type-like performances in social interaction, working memory and prepulse inhibition. However, Y2 mutant females exhibited a moderately increased ASR compared to control mice. Taken together, lack of Y2 signalling in mice not only leads to altered locomotion but also changes social behaviours and affects sensorimotor gating. Thus, Y2 depletion influences a range of behaviours, which are potentially relevant for schizophrenia-related research.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Karl T,Chesworth R,Duffy L,Herzog Hdoi
10.1016/j.bbr.2009.10.029subject
Has Abstractpub_date
2010-03-05 00:00:00pages
434-40issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(09)00638-Xjournal_volume
207pub_type
杂志文章abstract::The involvement of the motor system in action language comprehension is a hotly debated topic in cognitive neuroscience and psychology. Recent studies suggest that primary motor cortex (M1) response to action language is context-sensitive rather than automatic and necessary. Specifically, semantic polarity (i.e. affir...
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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