Perirhinal cortex lesions that impair object recognition memory spare landmark discriminations.

Abstract:

:Rats with lesions in the perirhinal cortex and their control group learnt to discriminate between mirror-imaged visual landmarks to find a submerged platform in a watermaze. Rats initially learnt this discrimination passively, in that they were repeatedly placed on the platform in one corner of a square watermaze with walls of different appearance, prior to swimming to that same location for the first time in a subsequent probe trial. Perirhinal cortex lesions spared this passively learnt ability, despite the common visual elements shared by the guiding landmarks. These results challenge models of perirhinal function that emphasise its role in solving discriminations between stimuli with ambiguous or overlapping features, while underlining how this cortical region is often not required for spatial processes that involve the hippocampus.

journal_name

Behav Brain Res

authors

Nelson AJD,Olarte-Sánchez CM,Amin E,Aggleton JP

doi

10.1016/j.bbr.2016.07.031

subject

Has Abstract

pub_date

2016-10-15 00:00:00

pages

255-259

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(16)30459-4

journal_volume

313

pub_type

杂志文章
  • Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance.

    abstract::The present report describes the participation of nicotinic receptors (nAChRs) in controlling the excitability of local neuronal circuitries in the rat hippocampus and in the human cerebral cortex. The patch-clamp technique was used to record responses triggered by the non-selective agonist ACh and the alpha7-nAChR-se...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00208-4

    authors: Albuquerque EX,Pereira EF,Mike A,Eisenberg HM,Maelicke A,Alkondon M

    更新日期:2000-08-01 00:00:00

  • Heightened serotonin influences contest outcome and enhances expression of high-intensity aggressive behaviors.

    abstract::The outcome of behavioral interactions between organisms can have significant fitness implications. Therefore, it is of great theoretical and practical importance to understand the mechanisms that modify different agonistic behaviors. Changes in central monoamines, such as serotonin (5-HT), contribute to modifying the...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.10.050

    authors: Bubak AN,Renner KJ,Swallow JG

    更新日期:2014-02-01 00:00:00

  • Resilience against predator stress and dendritic morphology of amygdala neurons.

    abstract::Individual differences in coping response lie at the core of vulnerability to conditions like post-traumatic stress disorder (PTSD). Like humans, not all animals exposed to severe stress show lasting change in affect. Predator stress is a traumatic experience inducing long-lasting fear, but not in all rodents. Thus, i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.08.014

    authors: Mitra R,Adamec R,Sapolsky R

    更新日期:2009-12-28 00:00:00

  • Acquisition of a spatial conditioned place preference is impaired by amygdala lesions and improved by fornix lesions.

    abstract::This experiment examined the role of the lateral nucleus of the amygdala, the hippocampus and the dorsal striatum in the acquisition of a conditioned place preference (CPP). The CPP was established on a radial maze which was rotated before each daily trial so that only distal cues could be used to distinguish among lo...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90122-7

    authors: White NM,McDonald RJ

    更新日期:1993-06-30 00:00:00

  • Meranzin hydrate elicits antidepressant effects and restores reward circuitry.

    abstract::The burden of depression is enormous, and numerous studies have found that major depressive disorder (MDD) induces cardiovascular disorders (CVD) and functional dyspepsia (FD). Excitingly, meranzin hydrate (MH), an absorbed bioactive compound of Aurantii Fructus Immaturus, reverses psychosocial stress-induced mood dis...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.112898

    authors: Liu X,Zhou J,Zhang T,Chen K,Xu M,Wu L,Liu J,Huang Y,Nie B,Shen X,Ren P,Huang X

    更新日期:2021-02-01 00:00:00

  • Hippocampal theta activity related to elicitation and inhibition of approach locomotion.

    abstract::This study determined if the hippocampal theta rhythm showed phase relationships or changes in amplitude and frequency with the onset of stimuli and locomotion in a task in which auditory cues initiated and suppressed approach locomotion. Rats with electrodes in the dorsal hippocampus lapped at a milk dipper and were ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.12.006

    authors: Sinnamon HM

    更新日期:2005-05-28 00:00:00

  • The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls--a randomized placebo-controlled, double-blind fMRI study.

    abstract::In schizophrenia patients negative symptoms and cognitive impairment often persist despite treatment with second generation antipsychotics leading to reduced quality of life and psychosocial functioning. One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bbr.2012.09.034

    authors: Guse B,Falkai P,Gruber O,Whalley H,Gibson L,Hasan A,Obst K,Dechent P,McIntosh A,Suchan B,Wobrock T

    更新日期:2013-01-15 00:00:00

  • Preventive and therapeutic effects of environmental enrichment in Wistar rats submitted to neonatal hypoxia-ischemia.

    abstract::Environmental enrichment (EE) at early stages of neurodevelopment attenuates HI-induced behavioral, histological and cellular damage. However, the effects of EE exposure during gestational or early postnatal period and the possible influence of sexual dimorphism on EE protection are not fully understood. Present study...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.11.036

    authors: Durán-Carabali LE,Arcego DM,Sanches EF,Odorcyk FK,Marques MR,Tosta A,Reichert L,Carvalho AS,Dalmaz C,Netto CA

    更新日期:2019-02-01 00:00:00

  • Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats.

    abstract::The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasega...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(99)00029-7

    authors: Kitaichi K,Noda Y,Miyamoto Y,Numaguchi A,Osawa H,Hasegawa T,Furukawa H,Nabeshima T

    更新日期:1999-08-01 00:00:00

  • Schizophrenia-relevant behaviours in a genetic mouse model for Y2 deficiency.

    abstract::Expression levels of neuropeptide Y (NPY) are changed in schizophrenia patients. However, the direction of changes to NPY expression and the mechanisms behind NPY's impact on the development of the illness is not understood in detail. Here we investigated whether alterations in Y2 activity may be involved in the devel...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.10.029

    authors: Karl T,Chesworth R,Duffy L,Herzog H

    更新日期:2010-03-05 00:00:00

  • Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats.

    abstract::Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(99)00174-6

    authors: Field EF,Whishaw IQ,Pellis SM

    更新日期:2000-05-01 00:00:00

  • Effects of gabaergic drugs on reserpine-induced oral dyskinesia.

    abstract::Recently we have described the antidyskinetic property of the GABA mimetic drugs valproic acid and topiramate on reserpine-induced oral dyskinesia. In this respect, oral dyskinesia has been associated with important neuropathologies. The present study investigates the effects of different doses of the GABA(A) agonist ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.11.014

    authors: Peixoto MF,Araujo NP,Silva RH,Castro JP,Fukushiro DF,Faria RR,Zanier-Gomes PH,Medrano WA,Frussa-Filho R,Abílio VC

    更新日期:2005-05-07 00:00:00

  • Posterior parietal cortex lesions severely disrupt spatial learning in DBA mice characterized by a genetic hippocampal dysfunction.

    abstract::C57BL/6 (C57) and DBA/2 (DBA) inbred mice with posterior parietal cortex or sham lesions were tested in a radial eight-arm maze task with all the paths baited. In the high learner C57 strain, parietal lesions produced a limited impairment of performance without affecting maze-running strategies while the same lesions ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(97)00213-1

    authors: Ammassari-Teule M,Save E,de Marsanich B,Thinus-Blanc C

    更新日期:1998-09-01 00:00:00

  • Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine.

    abstract::Gene targeting experiments, in which both alleles of the Nurr1 gene were deleted, have shown that this molecule plays an essential role in the development of midbrain dopaminergic neurons, as shown by the loss of dopaminergic markers and the neurotransmitter dopamine (DA) in the ventral mesencephalon of Nurr1 null mut...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(03)00029-9

    authors: Bäckman C,You ZB,Perlmann T,Hoffer BJ

    更新日期:2003-07-14 00:00:00

  • Effects of acute restraint and unpredictable chronic mild stress on brain corticotrophin releasing factor mRNA in the elevated T-maze.

    abstract::Corticotrophin releasing factor (CRF) modulates stress/anxiety-related responses. Previous studies showed that exposure to acute restraint and unpredictable chronic mild stress (UCMS) facilitates elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. This study verified the role of CRF in the modulation...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.09.029

    authors: de Andrade JS,Céspedes IC,Abrão RO,da Silva JM,Ceneviva R,Ribeiro DA,Bittencourt JC,Viana MB

    更新日期:2018-01-30 00:00:00

  • Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat.

    abstract::In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.11.021

    authors: Ciric J,Lazic K,Kapor S,Perovic M,Petrovic J,Pesic V,Kanazir S,Saponjic J

    更新日期:2018-02-26 00:00:00

  • Virtual environment navigation tasks and the assessment of cognitive deficits in individuals with brain injury.

    abstract::Navigation in real environments is often impaired by traumatic brain injury (TBI). These deficits in wayfinding appear to be due to disruption of cognitive processes underlying navigation and may in turn be due to damage to the hippocampus and frontal lobes. These wayfinding problems after TBI were investigated using ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.07.015

    authors: Livingstone SA,Skelton RW

    更新日期:2007-12-11 00:00:00

  • Development of collection precedes targeted reaching: resting shapes of the hands and digits in 1-6-month-old human infants.

    abstract::Hand shaping is an important part of many skilled hand movements and includes a number of hand shapes prominent amongst which is collection. In collection, the hand is held with the digits lightly closed and flexed. It occurs when the hand is at rest and it occurs as the hand is transported to a target in behaviors su...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.04.052

    authors: Sacrey LA,Whishaw IQ

    更新日期:2010-12-06 00:00:00

  • Neural basis of psychomotor stimulant and opiate reward: evidence suggesting the involvement of a common dopaminergic system.

    abstract::Data are reviewed that suggest a common neural system may be involved in the rewarding properties of psychomotor stimulant and opiate drugs. This neural system corresponds to elements in the ventral tegmental dopamine system with cell bodies in the ventral tegmentum and axon terminals in the nucleus accumbens. Several...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(86)90032-x

    authors: Bozarth MA

    更新日期:1986-11-01 00:00:00

  • Immune activation during mid-gestation disrupts sensorimotor gating in rat offspring.

    abstract::Maternal immune activation (MIA) is a newly developed animal model of schizophrenia. It has recently been reported that when MIA is induced with the cytokine inducer polyinosinic-polycytidilic acid (poly I:C) rats do not show deficits in prepulse inhibition (PPI), a test that is often considered a validity benchmark. ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.02.021

    authors: Wolff AR,Bilkey DK

    更新日期:2008-06-26 00:00:00

  • TMS evidence for a selective role of the precuneus in source memory retrieval.

    abstract::The posteromedial cortex including the precuneus (PC) is thought to be involved in episodic memory retrieval. Here we used continuous theta burst stimulation (cTBS) to disentangle the role of the precuneus in the recognition memory process in a sample of healthy subjects. During the encoding phase, subjects were prese...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.12.032

    authors: Bonnì S,Veniero D,Mastropasqua C,Ponzo V,Caltagirone C,Bozzali M,Koch G

    更新日期:2015-04-01 00:00:00

  • Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation.

    abstract::Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-HT fibers and recipr...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.07.003

    authors: Hestermann D,Temel Y,Blokland A,Lim LW

    更新日期:2014-10-15 00:00:00

  • Long-term deficits of the paretic limb follow post-stroke compensatory limb use in C57BL/6 mice.

    abstract::Stroke is a leading cause of long-term disability that most often results in impairment of a single limb, contralateral to the injury (paretic limb). While stroke survivors often receive some type of rehabilitative training, chronic deficits persist. It has been suggested that compensatory use of the nonparetic limb i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.01.055

    authors: Kerr AL,Cheffer KA,Curtis MC,Rodriguez A

    更新日期:2016-04-15 00:00:00

  • Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice.

    abstract::In humans, anxiety is accompanied by changes in autonomic nervous system function, including increased heart rate, body temperature, and blood pressure, and decreased heart rate variability. In rodents, anxiety is inferred by examining anxiety-related behavioral responses such as avoidance and freezing, and more infre...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.11.025

    authors: Depino AM,Gross C

    更新日期:2007-02-27 00:00:00

  • Npas4 deficiency increases vulnerability to juvenile stress in mice.

    abstract::During specific windows of postnatal brain development, individuals are particularly susceptible to developing mental illnesses in adulthood. Adolescence is such a window during which environmental stress can have long-lasting consequences on social and cognitive functions. In individuals, highly vulnerable to stress,...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.04.027

    authors: Coutellier L,Gilbert V,Shepard R

    更新日期:2015-12-15 00:00:00

  • Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice.

    abstract::Prolonged and sustained stimulation of the hypothalamo-pituitary-adrenal axis have adverse effects on numerous brain regions, including the cerebellum. Motor coordination and motor learning are essential for animal and require the regulation of cerebellar neurons. The G-protein-coupled cannabinoid CB1 receptor coordin...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.01.036

    authors: Tomas-Roig J,Piscitelli F,Gil V,Del Río JA,Moore TP,Agbemenyah H,Salinas-Riester G,Pommerenke C,Lorenzen S,Beißbarth T,Hoyer-Fender S,Di Marzo V,Havemann-Reinecke U

    更新日期:2016-04-15 00:00:00

  • Bifidobacteria modulate cognitive processes in an anxious mouse strain.

    abstract::Increasing evidence suggests that a brain-gut-microbiome axis exists, which has the potential to play a major role in modulating behaviour. However, the role of this axis in cognition remains relatively unexplored. Probiotics, which are commensal bacteria offering potential health benefit, have been shown to decrease ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.02.044

    authors: Savignac HM,Tramullas M,Kiely B,Dinan TG,Cryan JF

    更新日期:2015-01-01 00:00:00

  • Training-induced structural changes in the adult human brain.

    abstract::Structural and functional brain reorganisation can occur beyond the developmental maturation period and this was recently recognised as an intrinsic property of the human central nervous system. Brain injury or altered afferent input due to environmental changes, novel experience and learning new skills are known as m...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2008.02.015

    authors: Draganski B,May A

    更新日期:2008-09-01 00:00:00

  • Postural performance in decerebrated rabbit.

    abstract::It is known that animals decerebrated at the premammillary level are capable of standing and walking without losing balance, in contrast to postmammillary ones which do not exhibit such behavior. The main goals of the present study were, first, to characterize the postural performance in premammillary rabbits, and, se...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.02.011

    authors: Musienko PE,Zelenin PV,Lyalka VF,Orlovsky GN,Deliagina TG

    更新日期:2008-06-26 00:00:00

  • Possible role of nitric oxide in the locomotor activity of hypertensive rats.

    abstract::We aimed to analyze whether hypertension and changes in nitric oxide (NO) generation are associated with alterations of locomotor activity in rats. Male Wistar rats treated with an inhibitor of NO synthase, NG-nitro-L-arginine methyl ester (L-NAME, 40 mg/kg/day) for 6 weeks, control Wistar rats, spontaneously hyperten...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.07.021

    authors: Pechánová O,Jendeková L,Kojsová S,Jagla F

    更新日期:2006-11-01 00:00:00