Abstract：
:During specific windows of postnatal brain development, individuals are particularly susceptible to developing mental illnesses in adulthood. Adolescence is such a window during which environmental stress can have long-lasting consequences on social and cognitive functions. In individuals, highly vulnerable to stress, a relatively mild stressful situation can trigger the onset of psychiatric conditions. The genetic factors and mechanisms underlying vulnerability to stress are not well understood. Here, we show that variations in expression of the brain-specific transcription factor Npas4 contributes to the long-term consequences of juvenile stress on cognitive abilities. We observed that transgenic Npas4-deficient mice exposed to chronic mild stress during adolescence (but not during adulthood) develop prefrontal cortex-dependent cognitive deficits in adulthood, while the same stress did not affect Npas4 wild-type mice. These cognitive deficits were accompanied by fewer neuroblasts in the subventricular zone, and reduced ability of these immature neuronal cells to migrate away from this neurogenic zone toward cortical regions. These findings suggest for the first time that the transcription factor Npas4 could play a significant role in coping with juvenile stress. They also suggest that Npas4 could modulate resilience or vulnerability to stress by mediating the effects of stress on neurogenesis.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Coutellier L,Gilbert V,Shepard Rdoi
10.1016/j.bbr.2015.04.027subject
Has Abstractpub_date
2015-12-15 00:00:00pages
17-25eissn
0166-4328issn
1872-7549pii
S0166-4328(15)00269-7journal_volume
295pub_type
杂志文章abstract：:Attention deficit hyperactivity disorder (ADHD) has been described as the most prevalent behavioral disorder in children. Developmental coordination disorder (DCD) is one of the most prevalent childhood movement disorders. The overlap between the two conditions is estimated to be around 50%, with both substantially in...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2011.08.048
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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