Abstract：
:Some behavioral effects of GABA in the hippocampus and its probable interaction with histamine in adult male rats were studied. Four experiments were performed. In Expt. 1, rats were implanted unilaterally into the ventral hippocampus and they were microinjected with increasing doses of GABA. Five minutes later the following behavioral scores were measured in a holeboard: (1) locomotion, (2) head-dipping and (3) rearing. Results showed that GABA induced an increase in locomotion and a decrease in the frequency of long-lasting rears. In Expt. 2, the implanted rats were microinjected into the ventral hippocampus with Gamma-vinyl-GABA (GVG), an inhibitor of the metabolizing enzyme of GABA and picrotoxin and bicuculline, both antagonists of GABA. The following behaviors were measured later in the holeboard: (1) locomotion, (2) head-dipping frequency, (3) rearing activity and (4) grooming frequency. Results showed that GVG also increased the locomotor activity and this effect was antagonized by picrotoxin and bicuculline. In Expt. 3 the brain endogenous levels of GABA were measured in rats microinjected with GVG. Results showed that the GVG injection into the hippocampus augmented the endogenous levels of GABA. In Expt. 4 the implanted rats were microinjected into the hippocampus with GVG and histamine. Behavioral scores were measured later in the holeboard. Results showed that the increase in locomotion induced by GVG was blocked by the administration of histamine. Present results show that GABA may be involved in some hippocampal-mediated behaviors and suggest a histamine-GABA link in the final expression of these behaviors.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Alvarez EO,Banzan AMdoi
10.1016/0166-4328(90)90088-vsubject
Has Abstractpub_date
1990-03-05 00:00:00pages
133-43issue
2eissn
0166-4328issn
1872-7549pii
0166-4328(90)90088-Vjournal_volume
37pub_type
杂志文章abstract：:We review some of the evidence for structural changes in synapses in response to environmental stimulation. These include changes in synapse number, in distribution of presynaptic vesicles, in synaptic bouton size, and complex changes in the shape and size of synaptic contact zones. Increased numbers of postsynaptic p...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00116-w
更新日期：1995-01-23 00:00:00
abstract：:The present study tested eight boys with attention-deficit/hyperactivity disorder (ADHD) and 12 normal boys (comparison group), aged 7-12 years, to investigate the hypothesis that ADHD is associated with a steeper and shorter delay-of-reinforcement gradient than is normal. A two-component schedule of reinforcement was...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(98)00049-7
更新日期：1999-01-01 00:00:00
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journal_title：Behavioural brain research
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pub_type： 杂志文章
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更新日期：2015-05-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2017-08-14 00:00:00
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pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2004-01-05 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.10.011
更新日期：2004-07-09 00:00:00
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doi：10.1016/j.bbr.2010.10.035
更新日期：2011-04-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.04.028
更新日期：2017-06-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.03.056
更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-4328(88)90050-2
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pub_type： 杂志文章
doi：10.1016/j.bbr.2016.01.057
更新日期：2016-04-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.10.058
更新日期：2013-02-15 00:00:00
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journal_title：Behavioural brain research
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pub_type： 杂志文章
doi：10.1016/0166-4328(96)00136-2
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pub_type： 杂志文章
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更新日期：2003-12-17 00:00:00
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doi：10.1016/j.bbr.2004.05.018
更新日期：2005-01-06 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,meta分析,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2021-01-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2009-03-17 00:00:00
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journal_title：Behavioural brain research
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更新日期：2011-09-23 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(96)00124-6
更新日期：1996-01-01 00:00:00
abstract：:In a recent study with the Poffenberger paradigm, Brizzolara et al. reported longer estimates of interhemispheric transfer time (IHTT) for children aged 7 years than for adults. They interpreted this finding as evidence for incomplete functional maturity of the corpus callosum in young children. The present study was ...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1997-07-01 00:00:00
