Abstract:
:Increasing CREB-dependent transcription in dentate gyrus (DG) granule cells in vivo using viral-mediated expression of a constitutively active form of CREB (CREBCA) is sufficient to enhance contextual fear memory but whether this treatment renders memory abnormally enduring is unknown. Here we confirm that over-expressing CREBCA in the DG increases retention of contextual fear conditioning (CFC) and show that this memory decays normally. Specifically, the retention scores of CREBCA mice are significantly higher than those of GFP-infected controls 24h after the conditioning, but match them after a longer exposure session and are still in the same range 48 h later. Our findings provide evidence that boosting selectively CREB activity in the DG promotes the formation of a stronger memory trace but does not increase its resistance to extinguish.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Vetere G,Marchetti C,Benevento M,Tafi E,Marie H,Ammassari-Teule Mdoi
10.1016/j.bbr.2011.04.004subject
Has Abstractpub_date
2011-09-23 00:00:00pages
394-6issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00291-9journal_volume
222pub_type
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