Abstract:
:A rat model of alloxan-induced diabetes was used to investigate the effect of diabetic state on serotonin (5-HT) levels in peripheral body compartments, gastrointestinal (GI) and platelet, and the metabolic response of these compartments to serotonin precursor (5-hydroxytryptophan, 5-HTP) loading in diabetes. In all segments of diabetic gut a massive reduction in 5-HT concentration (to 45-64% at 6th week after induction of diabetes, with further progression to 30-52% at 14th week) was shown. After parenteral loading with 5-HTP for 6 days (30 mg/kg per day) 5-HT concentration in all parts of the GI tract returned to the control values (82-108%), indicating reduced serotonin precursor availability in diabetes. Platelet serotonin levels (PSL) in diabetic rats demonstrated a slight gradual reduction that became significant at 14th week of diabetic state. On the mentioned 5-HTP challenge only blunted response of PSL in diabetics, as contrasted to control animals (54% vs. 113%) was shown, indicating possible suppression of the membrane 5-HT transporter. The observed alterations in peripheral 5-HT homeostasis in diabetic rats as well as the possibility of their reversal by 5-HTP treatment could be of clinical interest.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Cićin-Sain L,Jernej Bdoi
10.1016/0166-4328(96)00124-6subject
Has Abstractpub_date
1996-01-01 00:00:00pages
285-8issue
1-2eissn
0166-4328issn
1872-7549pii
0166-4328(96)00124-6journal_volume
73pub_type
杂志文章abstract::The involvement of the motor system in action language comprehension is a hotly debated topic in cognitive neuroscience and psychology. Recent studies suggest that primary motor cortex (M1) response to action language is context-sensitive rather than automatic and necessary. Specifically, semantic polarity (i.e. affir...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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journal_title:Behavioural brain research
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pub_type: 杂志文章
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2008.03.006
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00104-6
更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1994-01-31 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.07.008
更新日期:2005-12-07 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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