Abstract:
:The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompanied by hyperreactivity to aversive solutions of quinine. NA-depleted rats also displayed rejection 'thresholds' for ethanol solutions that were significantly lower than those of controls. Depletion of forebrain NA did not, however, affect the punishing effects of ethanol injections measured in the conditioned taste aversion paradigm. In contrast to these effects of NA depletion on initiation of ethanol intake, depletion of forebrain NA after a preference for ethanol had been established failed to affect subsequent intake of ethanol. These results suggest that forebrain NA is involved in the initiation of ethanol intake by naive rats but not in the maintenance of established patterns of intake by experienced rats. Possible mechanisms for this differential involvement of NA are discussed.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Corcoran ME,Lewis J,Fibiger HCdoi
10.1016/0166-4328(83)90168-7subject
Has Abstractpub_date
1983-04-01 00:00:00pages
1-21issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(83)90168-7journal_volume
8pub_type
杂志文章abstract::Neurons in the isthmo-optic nucleus (ION) of the avian midbrain receive input predominantly from the ipsilateral optic tectum and project to the contralateral retina. Therefore, lesion in the ION removes tectal efferent signals to the retina in birds. In the present study, we trained Japanese quail to reach a target s...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2001-04-08 00:00:00
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2007-12-11 00:00:00
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更新日期:2006-06-30 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.12.005
更新日期:2007-03-12 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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journal_title:Behavioural brain research
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更新日期:2004-07-09 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2007-12-03 00:00:00
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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更新日期:2000-06-01 00:00:00
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更新日期:2018-10-01 00:00:00
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journal_title:Behavioural brain research
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pub_type: 杂志文章
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更新日期:2017-06-30 00:00:00