Abstract：
:In order to investigate the role of the dorsomedial and dorsolateral caudate-putamen (CPu) in movement initiation of rats, we examined the effects of quinolinic acid lesions (30 nmol in 1 microliter) in these striatal subregions in a simple reaction time task. Results show that lesions of the dorsomedial, but not of the dorsolateral CPu increased reaction times. These findings provide further evidence for a functional heterogenity of the CPu and demonstrate an involvement of the dorsomedial CPu in processes related to rapid initiation of responses.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Hauber W,Schmidt WJdoi
10.1016/0166-4328(94)90149-xsubject
Has Abstractpub_date
1994-02-28 00:00:00pages
211-5issue
2eissn
0166-4328issn
1872-7549pii
0166-4328(94)90149-Xjournal_volume
60pub_type
杂志文章abstract：:Motor performance declines with increasing age and it has been proposed that elder people might compensate for these deficits with increased cerebral activation. However, it is not known, whether increased activation - especially in motor areas of the contralateral and the ipsilateral cerebral hemisphere - might effec...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.04.040
更新日期：2011-10-01 00:00:00
abstract：:Prenatal restraint stress (PS) has been suggested as an attractive chronic model of anxiety. Here, we characterized the behavioral and autonomic responsivity to acute stress exposure in adult PS subjects. In Wistar rats, locomotor activity, as well as spontaneous behavior in an established animal model of anxiety, the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00273-5
更新日期：2003-03-18 00:00:00
abstract：:Research into object recognition memory has been galvanised by the introduction of spontaneous preference tests for rodents. The standard task, however, contains a number of inherent shortcomings that reduce its power. Particular issues include the problem that individual trials are time consuming, so limiting the tot...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2014.07.049
更新日期：2015-05-15 00:00:00
abstract：:In schizophrenia patients negative symptoms and cognitive impairment often persist despite treatment with second generation antipsychotics leading to reduced quality of life and psychosocial functioning. One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal...
journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bbr.2012.09.034
更新日期：2013-01-15 00:00:00
abstract：:It has recently been reported that psychotic symptoms in patients such as those with Parkinson's disease dementia (PDD) and Lewy body dementia (LBD) may worsen following treatment with memantine, a non-competitive NMDA receptor antagonist. Prepulse inhibition (PPI) of the acoustic startle response (ASR) is used as a m...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.11.053
更新日期：2011-03-17 00:00:00
abstract：:Prepulse inhibition (PPI) of the acoustic startle reflex has been extensively employed as a test of sensorimotor gating or early attentional control in neuropsychiatric research, because a number of psychiatric conditions, including schizophrenia, exhibit PPI deficiencies. In both human and animal studies, PPI is comm...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.11.049
更新日期：2009-12-07 00:00:00
abstract：:The cholinergic hypothesis of memory dysfunction originally proposed that dysfunction of cholinergic neurons in the basal forebrain cholinergic system (BFCS) may be responsible for the memory deficits associated with aging and Alzheimer's disease (AD). This hypothesis directed focus on the BFCS in experimental animal ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(95)00143-3
更新日期：1996-02-01 00:00:00
abstract：:Integrating research efforts using a cross-domain approach could redefine traditional constructs used in behavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not from functional isolation but from integration. Our research group has been examining the interface between cogniti...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2014.05.028
更新日期：2015-01-01 00:00:00
abstract：:S-100 beta, a gene triplicated in Down Syndrome (DS), is thought to play a role in development of the brain in general, and in the serotonergic neuronal system in particular. We have been studying an animal model of DS, based on overexpression of this gene. In the current study, we report on the social behaviors of th...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00373-x
更新日期：2003-05-15 00:00:00
abstract：:The α9α10-subtype of nicotinic acetylcholine receptor (nAChR) has recently garnered interest in biomedicine and is being pursued as an analgesic target. However, the receptor exhibits diverse tissue distribution, the function of which is known to varying degrees, and targeting this receptor for clinical treatments wit...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.04.005
更新日期：2017-06-15 00:00:00
abstract：:Research investigating how control over stressors affects behavior often utilizes freezing and shuttle escape learning as the behavioral endpoints. These endpoints have been argued to reflect anxious or depressed states, but these descriptions are problematic. The present study sought to determine the impact of stress...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.04.024
更新日期：2008-11-03 00:00:00
abstract：:Expression levels of neuropeptide Y (NPY) are changed in schizophrenia patients. However, the direction of changes to NPY expression and the mechanisms behind NPY's impact on the development of the illness is not understood in detail. Here we investigated whether alterations in Y2 activity may be involved in the devel...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.10.029
更新日期：2010-03-05 00:00:00
abstract：:Prefrontal cortical dendritic spine remodeling during adolescence may open a window of vulnerability to pathological stimuli that impact long-term behavioral outcomes, but causal mechanisms remain unclear. We administered the Rho-kinase inhibitor HA-1077 during three adolescent periods in mice to destabilize dendritic...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.01.004
更新日期：2013-04-15 00:00:00
abstract：:Emotional information, such as reward or punishment, gains rapid and often preferential access to neurocognitive resources. This ability to quickly evaluate and integrate emotion-related information is thought to benefit a range of behaviours critical for survival. Conversely, the improper use of, or preoccupation wit...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2010.10.030
更新日期：2011-02-02 00:00:00
abstract：:The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We investigated the effect of prenata...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.022
更新日期：2014-11-01 00:00:00
abstract：:Globoid cell leukodystrophy (Krabbe's disease) is an autosomal recessive neurodegenerative disorder that results from the deficiency of galactosylceramidase, a lysosomal enzyme involved in active myelination. Due to the progressive, lethal nature of this disease and the limited treatment options available, multiple la...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.08.020
更新日期：2013-01-01 00:00:00
abstract：:The relevance of adult neurogenesis in hippocampal function is well documented, as is the potential impact stress has on the adult neurogenic niche. Adult born neurons are generated from neural precursors in the dentate gyrus (DG), although the point in postnatal development that these cell precursors originate is not...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.11.013
更新日期：2015-02-15 00:00:00
abstract：:Antagonists of group I metabotropic receptors exhibit anxiolytic action in adult rats. In immature animals we demonstrated anticonvulsant action of MPEP and AIDA, antagonists of group 5 and group 1, respectively. However, there are no developmental data on anxiolytic-like and learning actions of both compounds. This s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.05.032
更新日期：2009-12-01 00:00:00
abstract：:Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. We designed a novel ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.12.040
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:The applicability of various neurological scores has not been sufficiently characterized in the anterior injection model of subarachnoid hemorrhage (SAH). Therefore this study was performed to evaluate different behavioral tests for quantifying disease severity. METHODS:Different volumes of autologous blood...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.02.004
更新日期：2017-04-14 00:00:00
abstract：:The congenitally helpless rat strain, which was selectively bred for increased susceptibility to learned helplessness, may model the predisposition to affective disorders, including depression and post-traumatic stress disorder. Other than the selected trait, the behavior of this strain is not well characterized. In t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.06.016
更新日期：2005-11-07 00:00:00
abstract：:This study examined the nociceptive effects of the intrathecal administration of various doses of the following endogenous excitatory sulphur-containing amino acids (SAAs): L-cysteic acid (L-CA), L-cysteine sulfinic acid (L-CSA), L-homocysteic acid (L-HCA) and L-homocysteic sulfinic acid (L-HCSA). For a period of 10mi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00064-0
更新日期：2003-09-15 00:00:00
abstract：:Memory consolidation is the process by which recently acquired information becomes stable and is modulated by different neurotransmitters depending on the structure involved and the nature of the memory. Here we evaluate the participation of both D1 and D5 dopamine receptors in the CA1 region of the hippocampus in the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.06.027
更新日期：2014-09-01 00:00:00
abstract：:There are several reports that cognitive impairment is observed in stress related disorders and chronic stress impairs learning and memory. However, very few studies have looked into the possible ways of preventing this stress-induced deficit. This research study was conducted to evaluate the effects of quercetin, a n...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.05.015
更新日期：2014-08-15 00:00:00
abstract：:Paw use in a task consisting of the removal of a piece of adhesive paper from the snout was investigated in 80 mongrel and pure-bred domestic dogs (Canis familiaris). Population lateralisation was observed, but in opposite directions in the two sexes (animals were not desexed): males preferentially used their left paw...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.01.009
更新日期：2004-08-31 00:00:00
abstract：:In earlier experiments we have demonstrated that group-housing in a rather impoverished "standard" environment can be a crucial stress factor in male C57Bl/6 mice. The present study aimed at investigating the effect of combining a probable genetic vulnerability--postulated by the "Neurotrophin Hypothesis of Depression...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.04.015
更新日期：2008-10-10 00:00:00
abstract：:COR659 is a recently synthesized positive allosteric modulator (PAM) of the GABAB receptor. Similarly to all GABAB PAMs tested to date, COR659 has been reported to suppress different alcohol-related behaviors in rodents. The present study was designed to assess whether the anti-addictive properties of COR659 extend to...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.113045
更新日期：2021-02-26 00:00:00
abstract：:The present study investigated the impact of a spared nerve injury (SNI) on the daily performance of rats tested in two instrumental conditioning procedures: the progressive ratio (PR) schedule of food reinforcement to study motivation for an appetitive stimulus, and the 5-choice serial reaction time task (5-CSRTT), a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.02.050
更新日期：2015-06-01 00:00:00
abstract：:While the rat was performing a go/no-go alternation task with a 10-s delay period, neuronal activity was recorded from electrodes chronically implanted in the prefrontal cortex (PFC) and the dorsomedial thalamus (DMT). In both PFC and DMT, neuronal activity during the delay period prior to a 'go' response was differen...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(86)90229-9
更新日期：1986-06-01 00:00:00
abstract：:Attention to stimuli associated with a rewarding outcome may be mediated by the incentive motivational properties that the stimulus acquires during conditioning. Other theories of attention state that the prediction error (the discrepancy between the expected and the actual outcome) during conditioning guides attentio...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.04.009
更新日期：2012-06-15 00:00:00
