Differential effects of lesions of the dorsomedial and dorsolateral caudate-putamen on reaction time performance in rats.

Abstract:

:In order to investigate the role of the dorsomedial and dorsolateral caudate-putamen (CPu) in movement initiation of rats, we examined the effects of quinolinic acid lesions (30 nmol in 1 microliter) in these striatal subregions in a simple reaction time task. Results show that lesions of the dorsomedial, but not of the dorsolateral CPu increased reaction times. These findings provide further evidence for a functional heterogenity of the CPu and demonstrate an involvement of the dorsomedial CPu in processes related to rapid initiation of responses.

journal_name

Behav Brain Res

authors

Hauber W,Schmidt WJ

doi

10.1016/0166-4328(94)90149-x

subject

Has Abstract

pub_date

1994-02-28 00:00:00

pages

211-5

issue

2

eissn

0166-4328

issn

1872-7549

pii

0166-4328(94)90149-X

journal_volume

60

pub_type

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