Abstract:
:P11 cells were used as an in vitro model system to explore effects of exposure to 5-HT on levels of mRNA encoding 5-HT2A receptors. Exposure of cells to the agonist 5-HT resulted in a doubling of receptor mRNA levels. mRNA levels returned to control levels within 8-16 h. The stability of receptor mRNA transcripts was transiently increased, suggesting that a post-transcriptional process was responsible for the up-regulation of receptor mRNA. The 5-HT-induced increase in Levels on 5-HT2A receptor mRNA did not require de novo protein synthesis since the increase was not affected by prior treatment with the protein synthesis inhibitor cycloheximide. Results of studies in which the activity of protein kinase C was either increased with PMA or antagonized with bisindolylmaleimide indicated that protein phosphorylation was essential for increasing levels of 5-HT2A receptor mRNA. These findings suggest that PKC-dependent post-transcriptional and post-translational processes participate in regulating 5-HT2A receptor mRNA expression.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ferry RC,Molinoff PBdoi
10.1016/0166-4328(96)00094-0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
187-91issue
1-2eissn
0166-4328issn
1872-7549pii
0166-4328(96)00094-0journal_volume
73pub_type
杂志文章,评审abstract::In this study we have explored differences in animal reactivity to conditioned aversive stimuli using the conditioned fear test (a contextual fear-freezing response), in rats subjected to the selective lesion of the prefrontal cortex serotonergic innervation, and differing in their response to the acute painful stimul...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.04.003
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00010-4
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(98)00011-4
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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pub_type: 杂志文章
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