Abstract：
:We have learned to detect, predict and behaviorally respond to important changes in our environment on short and longer time scales. Therefore, brains of humans and higher animals build upon a perceptual and semantic salience stored in their memories mainly generated by associative reinforcement learning. Functionally, the brain needs to extract and amplify a small number of features of sensory input with behavioral relevance to a particular situation in order to guide behavior. In this review, I argue that dopamine action, particularly in sensory cortex, orchestrates layer-dependent local and long-range cortical circuits integrating sensory associated bottom-up and semantically relevant top-down information, respectively. Available evidence reveals that dopamine thereby controls both the selection of perceptually or semantically salient signals as well as feedback processing from higher-order areas in the brain. Sensory cortical dopamine thereby governs the integration of selected sensory information within a behavioral context. This review proposes that dopamine enfolds this function by temporally distinct actions on particular layer-dependent local and global cortical circuits underlying the integration of sensory, and non-sensory cognitive and behavioral variables.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Happel MFdoi
10.1016/j.bbr.2015.11.016subject
Has Abstractpub_date
2016-02-15 00:00:00pages
32-41eissn
0166-4328issn
1872-7549pii
S0166-4328(15)30287-4journal_volume
299pub_type
杂志文章,评审abstract：:The noradrenergic system was pharmacologically activated with the alpha 2 receptor antagonist, idazoxan (2 mg/kg i.p.), during the acquisition of a complex appetitive task requiring a shift in attention to stimulus dimension and in response strategy. Rats first learned a fixed path of 6 successive choices in a linear ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90118-x
更新日期：1990-06-18 00:00:00
abstract：:Dopamine (DA) is well known for its involvement in novelty-seeking, learning, and goal-oriented behaviors such as social behavior. However, little is known about how DA modulates social processes differentially in relation to sex and behavioral phenotype (e.g., personality). Importantly, the major DA cell groups (A8-A...
journal_title：Behavioural brain research
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abstract：:The differential outcome effect is when learning is enhanced through the application of different outcomes to different conditions of a task. Here we explore whether one difference in learning with differential outcomes is an enhanced categorisation of objects. We demonstrate that participants learning conditional dis...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.03.036
更新日期：2011-09-12 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2017-03-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.11.036
更新日期：2019-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00176-1
更新日期：2004-01-05 00:00:00
abstract：:Previous results indicated that damage and pharmacological inactivation of the basolateral amygdala (BLA) interfere with the attenuation of taste neophobia. A similar disruption of safe taste memories formation induced by the inhibition of protein synthesis in the perirhinal cortex (PRh) has been reported. Thus, we ha...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.02.038
更新日期：2012-05-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.01.014
更新日期：2016-04-01 00:00:00
abstract：:Exaggerated avoidance behavior is a predominant symptom in all anxiety disorders and its degree often parallels the development and persistence of these conditions. Both human and non-human animal studies suggest that individual differences as well as various contextual cues may impact avoidance behavior. Specifically...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.01.033
更新日期：2015-04-15 00:00:00
abstract：:One of the routine memory abilities impaired in amnesic patients with temporal-lobe damage is object-recognition memory--the ability to discriminate the familiarity of previously encountered objects. Reproducing this impairment has played a central role in animal models of amnesia during the past two decades, and unti...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(01)00367-9
更新日期：2001-12-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00339-9
更新日期：2001-02-15 00:00:00
abstract：:Based on the results of independent studies the involvement of norepinephrine in REM sleep regulation was known. Isolated studies showed that the effect could be mediated through either one or more subtypes of adrenoceptors. Earlier we have reported that REM-OFF neurons continue firing during REM sleep deprivation and...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.08.004
更新日期：2005-03-07 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.04.004
更新日期：2015-07-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.07.027
更新日期：2009-01-03 00:00:00
abstract：:Orexinergic system is involved in primary rewards; the neural circuit of the ventral tegmental area (VTA), nucleus accumbens (NAc), prefrontal cortex and amygdala represents overlapping elements mediating the rewarding effects of drugs and stressful experiences. The NAc integrates reward-related information from the V...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.08.021
更新日期：2019-01-01 00:00:00
abstract：:The effects of two cognition enhancers on avoidance impairment induced by the tricyclic antidepressant amitriptyline were assessed during shuttle-box avoidance acquisition and in previously trained mice of the DBA/2 strain. The nootropic agent piracetam (50, 100 or 200 mg/kg, i.p.) had slight or no effect in mice rece...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00066-1
更新日期：1997-12-01 00:00:00
abstract：:Cancer patients often suffer long-lasting affective and cognitive impairments as a result of chemotherapy treatment. Previous work in our lab has shown deficits in learning and memory and hippocampal cell proliferation in mice lasting up to 20 weeks following acute administration of thioTEPA. In this study, the effect...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.08.046
更新日期：2013-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1997-07-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.06.003
更新日期：2017-08-14 00:00:00
abstract：:The lighting environment where the baby born prematurely is placed is different from that experienced in utero. As early exposure to light may affect the immature visual system we have attempted to quantify the neonatal ocular light dose. Lighting surveys performed in 7 neonatal units (NNUs) suggested that mean unit i...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(05)80193-7
更新日期：1992-07-31 00:00:00
abstract：:Previous studies have shown that conditioned blocking of taste aversion learning in 3-month-old Wistar rats depends on the hippocampal system integrity. Thus, the aim was to demonstrate that enough connectivity would develop after a graft to support the attention mechanism required for conditioned blocking. In the fir...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)02311-5
更新日期：1997-10-01 00:00:00
abstract：:The structural characteristics of the area postrema, its anatomical connections, participation in the detection of emesis-provoking substances and the effects of area postrema lesions on taste aversion learning acquisition, are all factors which speak in favor of a role as a chemoreceptor zone involved in the detectio...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90172-6
更新日期：1988-10-01 00:00:00
abstract：:Aging has diverse effects on different behaviors and underlying neural systems. This study utilized fear conditioning to determine if aged mice have deficits in the acquisition and/or retention of memories for contextual or cued fear conditioning, and to determine if galantamine, an acetylcholinesterase (AChE) inhibit...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.06.040
更新日期：2005-12-07 00:00:00
abstract：:The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory i...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
abstract：:In the rat, prenatal exposure to diazepam (DZ) induces a permanent reduction in GABA/BZ receptor (R) function and behavioural abnormalities. Environmental modifications during early stages of life can influence brain development and induce neurobiological and behavioural changes throughout adulthood. Indeed, a subtle,...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.02.022
更新日期：2005-06-20 00:00:00
abstract：:This study investigated the possible influence of the Subdural Pharmacotherapy Device (SPD) on spatial memory in 3 adult, male bonnet macaques (Macaca radiata). The device was implanted in and above the subdural/subarachnoid space and cranium overlaying the right parietal/frontal cortex: a circuitry involved in spatia...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.03.014
更新日期：2015-06-01 00:00:00
abstract：:Prenatal ethanol exposure can lead to long-lasting impairments in the ability of rats to process spatial information, as well as produce long-lasting deficits in long-term potentiation (LTP), a biological model of learning and memory processing. The present study aimed to examine the sexually dimorphic effects of chro...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.09.017
更新日期：2013-11-01 00:00:00
