Abstract：
:This study investigated the possible influence of the Subdural Pharmacotherapy Device (SPD) on spatial memory in 3 adult, male bonnet macaques (Macaca radiata). The device was implanted in and above the subdural/subarachnoid space and cranium overlaying the right parietal/frontal cortex: a circuitry involved in spatial memory processing. A large test chamber, equipped with four baited and four non-baited food-ports at different locations, was used: reaches into empty food ports were counted as spatial memory errors. In this study of within-subject design, before SPD implantation (control) the animals made mean 373.3 ± 114.9 (mean ± SEM) errors in the first spatial memory test session. This value dropped to 47.7 ± 18.4 by the 8th session. After SPD implantation and alternating cycles of transmeningeal saline delivery and local cerebrospinal fluid (CSF) drainage in the implanted cortex the spatial memory error count, with the same port locations, was 33.0 ± 12.2 during the first spatial memory test session, further decreasing to 5.7 ± 3.5 by the 8th post-implantation session (P<0.001 for trend). Replacing transmeningeal saline delivery with similar delivery of the GABAA receptor agonist muscimol (1.0mM) by the SPD did not affect the animals' spatial memory performance, which in fact included at least one completely error-free session per animal over time. The study showed that complication-free implantation and use of the SPD over the parietal and frontal cortices for months leave spatial memory processes intact in nonhuman primates.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ludvig N,Tang HM,Baptiste SL,Stefanov DG,Kral JGdoi
10.1016/j.bbr.2015.03.014subject
Has Abstractpub_date
2015-06-01 00:00:00pages
293-9eissn
0166-4328issn
1872-7549pii
S0166-4328(15)00158-8journal_volume
286pub_type
杂志文章abstract：:BALB/cJ and C57BL/6J inbred mouse strains have been proposed as useful models of low and high levels of sociability (tendency to seek social interaction), respectively, based primarily on behaviors of ∼30-day-old mice in the Social Approach Test (SAT). In the SAT, approach and sniffing behaviors of a test mouse toward...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2012.08.051
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journal_title：Behavioural brain research
pub_type： 杂志文章
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abstract：:Although the increasing rate of obesity has stimulated interest in the effects of diet composition on peripheral systems, comparatively little work has been done to examine effects upon the brain. A diet high in fat is one of many factors that can promote obesity, and previous research has shown that such a diet can p...
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abstract：:Aim of the research was to evaluate, by means of quantitative and multivariate temporal pattern analyses, the behavior of Wistar rat in elevated plus maze (EPM) test. On the basis of an ethogram encompassing 24 behavioral elements, quantitative results showed that 130.14 ± 8.01 behavioral elements occurred in central ...
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.09.013
更新日期：2005-03-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.03.034
更新日期：2006-07-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
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更新日期：2002-07-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00302-8
更新日期：2000-12-20 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2009.10.013
更新日期：2010-03-05 00:00:00
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doi：10.1016/j.bbr.2013.04.025
更新日期：2013-08-01 00:00:00
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更新日期：1997-07-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2013-03-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.11.030
更新日期：2009-03-17 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2017-09-29 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-02 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2013-04-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.048
更新日期：2019-04-19 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.09.017
更新日期：2012-01-01 00:00:00
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