Abstract：
:It has been reported that more than one fourth of the world's population suffers from sleep problems. However, there is not a stable and reliable animal model to mimic the persistent and periodic features of sleep disorders, and correspondingly, the feasibility and effectiveness of repeated behavioral tests remains to be determined. In the present study, we repetitively, and intermittently, treated mice with 3days and 7days of paradoxical sleep deprivation (SD), using the modified multiple small-platforms-over-water method for 3 months. The behavioral results suggested that repeated open field and Y-maze tests are able to successfully detect anxiety-like behaviors and working memory dysfunction of the model mice. The Morris water maze test is not suitable for evaluating spatial learning ability following SD because the long-term utilization of the flower-pot method increases the familiarity of mice with the water environment. Moreover, neuroinflammation, microglial activation and neuronal apoptosis were observed in the hippocampus of model mice even recovery for 3 weeks later. This animal model and corresponding behavioral evaluation method will help to explore the pathogenesis and therapeutic strategies of chronic sleep disorders.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Yin M,Chen Y,Zheng H,Pu T,Marshall C,Wu T,Xiao Mdoi
10.1016/j.bbr.2016.12.034subject
Has Abstractpub_date
2017-03-15 00:00:00pages
69-78eissn
0166-4328issn
1872-7549pii
S0166-4328(16)30884-1journal_volume
321pub_type
杂志文章abstract：:Neglect in human and non-human primates has been demonstrated following unilateral lesions of both posterior parietal and prefrontal areas. While it has now been well established that a unilateral lesion of the rodent analog of dorsolateral prefrontal cortex, medial agranular cortex (AGm), results in neglect, the effe...
journal_title：Behavioural brain research
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pub_type： 杂志文章
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journal_title：Behavioural brain research
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更新日期：2007-10-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90105-n
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,meta分析,评审
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更新日期：2019-12-30 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2008.10.011
更新日期：2009-02-11 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.045
更新日期：2010-07-29 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bbr.2018.04.027
更新日期：2018-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.04.025
更新日期：2015-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.02.025
更新日期：2011-08-01 00:00:00
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更新日期：2019-04-19 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
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更新日期：2016-05-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2012-04-21 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2011-07-07 00:00:00
abstract：:This study examined visual discrimination performance in a sample of older adults before, during and post treadmill walking at preferred walking speed and preferred walking speed +20%. Nine adults (6 females and 3 males) aged 60-77 years (mean age=67.1±5.7 years) undertook three trials each lasting 15 min, rest, walki...
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pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
