Behavioral characterization of dysbindin-1 deficient sandy mice.


:Dysbindin-1 (dystrobrevin binding protein-1) has been reported as a candidate gene associated with schizophrenia. Dysbindin-1 mRNA and protein levels are significantly reduced in the prefrontal cortex and hippocampus of schizophrenia subjects. To understand the in-vivo functions of dysbindin-1, we studied schizophrenia relevant behaviors in adult male Sandy homozygous (sdy/sdy) and heterozygous (sdy/+) mice that have a natural mutation in dysbindin-1 gene (on a DBA/2J background) resulting in loss of protein expression. Spontaneous locomotor activity of sdy/sdy and sdy/+ mice in novel environment was not significantly different from DBA/2J controls. However, on repeated testing in the same environment for 7 days, sdy/sdy mice, in contrast to DBA/2J controls showed a lack of locomotor habituation. Locomotor activating effect of a low dose of d-amphetamine (2.5 mg/kg i.p.), a behavioral measure of mesolimbic dopamine activity, was significantly reduced in the mutant mice. Interestingly, sdy/sdy mice showed enhanced locomotor sensitization to repeated five daily injection of amphetamine. Possible cognitive impairment in Sandy mutants was revealed in novel object recognition test as sdy/sdy and sdy/+ mice spent significantly less time exploring novel objects compared to DBA/2J. Sdy/sdy mice also showed deficits in emotionally motivated learning and memory showing greater freezing response to auditory conditioned stimulus (CS) in fear conditioning paradigm. In thermal nociceptive test, the latency of paw withdrawal in sdy/sdy and sdy/+ animals was significantly higher compared to DBA/2J indicating hypoalgesia in the mutants. Taken together, these data suggest that dysbindin-1 gene deficiency leads to significant changes in cognition and altered responses to psychostimulants.


Behav Brain Res


Bhardwaj SK,Baharnoori M,Sharif-Askari B,Kamath A,Williams S,Srivastava LK




Has Abstract


2009-02-11 00:00:00














  • Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine.

    abstract::Gene targeting experiments, in which both alleles of the Nurr1 gene were deleted, have shown that this molecule plays an essential role in the development of midbrain dopaminergic neurons, as shown by the loss of dopaminergic markers and the neurotransmitter dopamine (DA) in the ventral mesencephalon of Nurr1 null mut...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Bäckman C,You ZB,Perlmann T,Hoffer BJ

    更新日期:2003-07-14 00:00:00

  • Neural correlates of affective empathy and reinforcement learning in boys with conduct problems: fMRI evidence from a gambling task.

    abstract:BACKGROUND:Conduct problems (CP) comprise abnormal behaviors associated with aberrant aspects of affective empathy as well as learning. However, behavioral measures for affective empathy are challenging, and previous results concerning learning in patients with CP are inconsistent. METHODS:Nineteen boys with CP and 24...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Schwenck C,Ciaramidaro A,Selivanova M,Tournay J,Freitag CM,Siniatchkin M

    更新日期:2017-03-01 00:00:00

  • Improved choline acetyltransferase immunohistochemistry in the red nucleus by blocking the axonal transport.

    abstract::Following blockage of the protein transport by colchicine or by interruption of the rubrofugal descending pathway, choline acetyltransferase-immunoreactive neurons were found in the red nucleus of the rat. Their morphology and location suggest that they are rubrospinal neurons. ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Onténiente B,Condé F

    更新日期:1988-04-01 00:00:00

  • Visual pathways and acuity hooded rats.

    abstract::Three experiments on the effects of lesions of the visual system on contrast-detection in hooded rats are described, in which the ability of rats to detect stationary high-contrast square-wave gratings of various fundamental frequencies presented in the central visual field was measured before and after operation. The...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Dean P

    更新日期:1981-09-01 00:00:00

  • Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.

    abstract::GABAB receptors are crucial modulators of the behavioural effects of drug abuse, and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of GABAB1 and GABAB2 subunits. The predominant neuronal GABAB1 subunit...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Jacobson LH,Sweeney FF,Kaupmann K,O'Leary OF,Gassmann M,Bettler B,Cryan JF

    更新日期:2016-02-01 00:00:00

  • Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice.

    abstract::β-Amyloid (Aβ) elevation, tau hyperphosphorylation, and neuroinflammation are major hallmarks of Alzheimer's disease (AD). Glycogen synthase kinase-3β (GSK-3β) is a key protein kinase implicated in the pathogenesis of AD. Blockade of GSK-3β is an attractive therapeutic strategy for AD. Isoorientin, a 6-C-glycosylflavo...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Tan X,Liang Z,Li Y,Zhi Y,Yi L,Bai S,Forest KH,Nichols RA,Dong Y,Li QX

    更新日期:2021-02-01 00:00:00

  • Mediodorsal thalamic lesions impair acquisition of an eyeblink avoidance response in rabbits.

    abstract::Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on four sessions of instrumental avoidance conditioning, during which an eyeblink (EB) response during the presentation of a tone-conditioned stimulus prevented the occurrence of a paraor...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Buchanan SL

    更新日期:1994-12-15 00:00:00

  • The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.

    abstract::Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Cappendijk SL,Fekkes D,Dzoljic MR

    更新日期:1994-11-16 00:00:00

  • Intra hippocampal injection of testosterone impaired acquisition, consolidation and retrieval of inhibitory avoidance learning and memory in adult male rats.

    abstract::The hippocampus is essentially involved in learning and memory, and is known to be a target for androgen actions. Androgen receptors are densely expressed in CA1 of rat hippocampus, and mediate the effects of testosterone (T) on learning and memory. T depletion or administration can modulate neural function and cognit...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Harooni HE,Naghdi N,Sepehri H,Rohani AH

    更新日期:2008-03-17 00:00:00

  • Unconditioned and conditioned factors contribute to the 'reinstatement' of cocaine place conditioning following extinction in C57BL/6 mice.

    abstract::Relapse to drug use following prolonged periods of abstinence results, in part, from the ability of contextual cues paired previously with self-administered drug to elicit drug craving and -seeking behavior. Given the popularity of the mouse for the genetic analysis of drug-induced behaviors, a place conditioning mode...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Szumlinski KK,Price KL,Frys KA,Middaugh LD

    更新日期:2002-10-17 00:00:00

  • Electrical stimulation of dorsal, but not ventral hippocampus reduces behavioral defense in the elevated plus maze and shock-probe burying test in rats.

    abstract::Recent evidence indicates that the hippocampus contributes to the control of defensive behaviors in rodents. Here, electrical stimulation (1s, 60 Hz) of the rat dorsal hippocampus inhibited defense in the elevated plus maze (increased open arm exploration) and shock-probe burying test (reduced burying duration), while...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Dringenberg HC,Levine Y,Menard JL

    更新日期:2008-01-10 00:00:00

  • Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils.

    abstract::NKP608 is a potent, selective and orally active non-peptidic neurokinin-1 (NK1)-receptor antagonist for which anxiolytic- and antidepressant-like effects have been described in various animal models in rats. Since species differences have been reported for some NK1-receptor antagonists, NKP608 was tested here in the s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Gentsch C,Cutler M,Vassout A,Veenstra S,Brugger F

    更新日期:2002-07-18 00:00:00

  • The relation of hippocampal subfield volumes to verbal episodic memory measured by the California Verbal Learning Test II in healthy adults.

    abstract::Total hippocampal volume has previously been shown to correlate with performance on tests for verbal episodic memory. However, there are sparse evidence on how hippocampal subfield volumes are related to verbal episodic memory in healthy adults. The present study investigated the association between volumes of separat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Aslaksen PM,Bystad MK,Ørbo MC,Vangberg TR

    更新日期:2018-10-01 00:00:00

  • MicroRNA-132 regulates total protein of Nav1.1 and Nav1.2 in the hippocampus and cortex of rat with chronic cerebral hypoperfusion.

    abstract::Nav1.1 and Nav1.2 are the voltage-gated sodium channel alpha subunit1 and 2, encoded by the genes of SCN1A and SCN2A. Previous studies have shown that chronic cerebral hypoperfusion (CCH) could induce neuropathological and cognitive impairment and increased total Nav1.1 and Nav1.2protein levels, yet the detailed mecha...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Hu XL,Wang XX,Zhu YM,Xuan LN,Peng LW,Liu YQ,Yang H,Yang C,Jiao L,Hang PZ,Sun LH

    更新日期:2019-07-02 00:00:00

  • Could adult hippocampal neurogenesis be relevant for human behavior?

    abstract::Although the function of adult neurogenesis is still unclear, tools for directly studying the behavioral role of new hippocampal neurons now exist in rodents. Since similar studies are impossible to do in humans, it is important to assess whether the role of new neurons in rodents is likely to be similar to that in hu...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审


    authors: Snyder JS,Cameron HA

    更新日期:2012-02-14 00:00:00

  • Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: interaction with a brief, daily maternal separation.

    abstract::Perinatal manipulations can lead to neurobehavioural changes in the progeny. In this study we investigated, in adolescent male rat offspring, the consequences of a single, intense prenatal stress induced by a 120 min-maternal immobilization at gestational day 16, and of a daily, brief maternal separation from postnata...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Cannizzaro C,Plescia F,Martire M,Gagliano M,Cannizzaro G,Mantia G,Cannizzaro E

    更新日期:2006-04-25 00:00:00

  • Stress impairs performance in spatial water maze learning tasks.

    abstract::The water maze task has been developed to test spatial learning abilities in rats or mice, and is widely used. Though it has been reported before that numerous cognitive abilities are of importance for learning this task, poor performance is usually interpreted as an impairment of spatial memory formation. Previous in...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Hölscher C

    更新日期:1999-04-01 00:00:00

  • Dietary supplementation with Salvia sahendica attenuates memory deficits, modulates CREB and its down-stream molecules and decreases apoptosis in amyloid beta-injected rats.

    abstract::Herein, we investigated the effect Salvia sahendica (S. sahenica) extract, an endemic plant of Iran on the improvement of learning and memory deficits in amyloid beta-(Aβ) injected rats. In order to test this hypothesis, we pretreated rats with S. sahendica 1 week prior to Aβ injection, then performed Morris water maz...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Khodagholi F,Ashabi G

    更新日期:2013-03-15 00:00:00

  • Effect of PICALM rs3851179 polymorphism on the default mode network function in mild cognitive impairment.

    abstract::Alterations in default mode network (DMN) functional connectivity (FC) might accompany the dysfunction of Alzheimer's disease (AD). Indeed, episodic memory impairment is a hallmark of AD, and mild cognitive impairment (MCI) has been associated with a high risk for AD. Phosphatidylinositol-binding clathrin assembly pro...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Sun DM,Chen HF,Zuo QL,Su F,Bai F,Liu CF

    更新日期:2017-07-28 00:00:00

  • Search strategies in a human water maze analogue analyzed with automatic classification methods.

    abstract::Although human spatial cognition is at the focus of intense research efforts, experimental evidence on how search strategies differ among age and gender groups remains elusive. To address this problem, we investigated the interaction between age, sex, and strategy usage within a novel virtual water maze-like procedure...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Schoenfeld R,Moenich N,Mueller FJ,Lehmann W,Leplow B

    更新日期:2010-03-17 00:00:00

  • Differences in the recovery rate of a learned forelimb movement after ablation of the motor cortex in right and left hemisphere in white rats.

    abstract::After ablation of the motor cortex contralateral to the preferred limb, rats were forced to use this limb in grasping food out of a horizontal tube by restraining the non-preferred foreleg with a bracelet. In a right-handed rat the motor behaviour is less impaired and the recovery is better after a left hemisphere les...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Miklyaeva EI,Varlinskaya EI,Ioffe ME,Mats VN,Pokazanyeva LN,Kulikov MA

    更新日期:1993-09-30 00:00:00

  • Role of inhibitory autophosphorylation of calcium/calmodulin-dependent kinase II (αCAMKII) in persistent (>24 h) hippocampal LTP and in LTD facilitated by novel object-place learning and recognition in mice.

    abstract::Experience-dependent synaptic plasticity is widely expressed in the mammalian brain and is believed to underlie memory formation. Persistent forms of synaptic plasticity in the hippocampus, such as long-term potentiation (LTP) and long-term depression (LTD) are particularly of interest, as evidence is accumulating tha...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Goh JJ,Manahan-Vaughan D

    更新日期:2015-05-15 00:00:00

  • Increased pSTS activity and decreased pSTS-mPFC connectivity when processing negative social interactions.

    abstract::We have previously shown that activity and connectivity within and between the action observation and mentalizing brain systems reflect the degree of positive dimensions expressed by social interactions such as cooperativity and affectivity, respectively. Here we aim to extend this evidence by investigating the neural...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Arioli M,Basso G,Carne I,Poggi P,Canessa N

    更新日期:2021-02-05 00:00:00

  • NMDA lesions in the medial prefrontal cortex impair the ability to inhibit responses during reversal of a simple spatial discrimination.

    abstract::Although lesion studies suggest that the rat medial prefrontal cortex (mPFc) is involved in the process necessary for reversal of a particular set of contingencies, the nature of lesion-induced deficits is unclear. The involvement of rat mPFc in reversal of a simple spatial discrimination was examined in the present s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Salazar RF,White W,Lacroix L,Feldon J,White IM

    更新日期:2004-07-09 00:00:00

  • Cocaine- and amphetamine-regulated transcript peptide (CART) in the central nucleus of amygdala potentiates behavioral and hormonal responses of the rat exposed to its predator.

    abstract::Since cocaine- and amphetamine-regulated transcript peptide (CART) regulates anxiety and stress in amygdala, we hypothesized that the peptide may also process negative psychological experience like fear. During acute exposure to a cat, the rat showed freezing behavior and subsequently, profound signs of anxiety in soc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Upadhya MA,Kokare DM,Subhedar NK

    更新日期:2013-04-15 00:00:00

  • Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.

    abstract::Identifying the mechanisms underlying the adverse effects of developmental neurotoxicants enables the design of therapies that can potentially reverse neurobehavioral deficits in adulthood. We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in ad...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Billauer-Haimovitch H,Slotkin TA,Dotan S,Langford R,Pinkas A,Yanai J

    更新日期:2009-12-28 00:00:00

  • Intrathecal administration of yohimbine impairs locomotion in intact rats.

    abstract::The effects of upper lumbar level intrathecal injection of yohimbine, an alpha2-noradrenergic antagonist, on overground locomotion in intact rats was studied. This treatment caused dose-dependent impairment of hindlimb locomotor movement, which varied from transient hindlimb paralysis at a dose of 200 microg/20 microl...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Majczyński H,Cabaj A,Sławińska U,Górska T

    更新日期:2006-12-15 00:00:00

  • The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.

    abstract::In recent years muscarinic receptor agonists and cholinesterase inhibitors have been developed for the treatment of Alzheimer's disease. We have evaluated examples from both classes of compounds in rodent tests of reference and working memory, as well as tests that are sensitive to the side-effects of these compounds....

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Dawson GR,Iversen SD

    更新日期:1993-11-30 00:00:00

  • The MAM-E17 schizophrenia rat model: Comprehensive behavioral analysis of pre-pubertal, pubertal and adult rats.

    abstract::The MAM-E17 model is one of the most accepted schizophrenia rat models, which follows the neurodevelopmental theory of the disease. While symptoms of MAM-E17 rats were studied extensively, their examinations were usually restricted to adulthood and in a few cases to prepuberty. It is well known, however, that schizoph...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: Kállai V,Tóth A,Gálosi R,Péczely L,Ollmann T,Petykó Z,László K,Kállai J,Szabó I,Karádi Z,Lénárd L

    更新日期:2017-08-14 00:00:00

  • Mnemonic functions of dorsal striatum and hippocampus in aversive conditioning.

    abstract::These experiments examined the mnemonic functions of hippocampus and dorsal striatum in Pavlovian aversive conditioning. Rats were trained in a single session by presenting three paired tones and footshocks. Immediately after training, they were given microinjections of D-amphetamine or vehicle into either dorsal hipp...

    journal_title:Behavioural brain research

    pub_type: 杂志文章


    authors: White NM,Salinas JA

    更新日期:2003-06-16 00:00:00