Abstract:
:The ventral medial prefrontal cortex (vmPFC) controls vulnerability to the negative effects of chronic or uncontrollable stress. Dominance status alters responses to social defeat in the conditioned defeat model, which is a model characterized by loss of territorial aggression and increased submissive and defensive behavior following an acute social defeat. We have previously shown that dominant individuals show a reduced conditioned defeat response and increased defeat-induced neural activation in the vmPFC compared to subordinates. Here, we tested the hypothesis that defeat-induced activation of the vmPFC is necessary to confer resistance to conditioned defeat in dominants. We paired weight-matched male Syrian hamsters (Mesocricetus auratus) in daily 5-min aggressive encounters for 2 weeks and identified dominants and subordinates. Twenty-four hours after the final pairing, animals were bilaterally injected with 200 nl of the GABAA receptor agonist muscimol (1.1 nmol) or 200 nl of saline vehicle 5 min prior to social defeat. Defeat consisted of 3, 5-min encounters with resident aggressor hamsters at 10-min intervals. Twenty-four hours following social defeat, animals received conditioned defeat testing which involved a 5-min social interaction test with a non-aggressive intruder. Muscimol injection prior to social defeat prevented the reduced conditioned defeat response observed in vehicle-treated dominants. Further, there was no effect of muscimol injection on the conditioned defeat response in subordinates or controls. These data support the conclusion that activation of the vmPFC during social defeat is necessary for the protective effects of dominant social status on the acquisition of conditioned defeat.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Morrison KE,Bader LR,McLaughlin CN,Cooper MAdoi
10.1016/j.bbr.2013.01.006subject
Has Abstractpub_date
2013-04-15 00:00:00pages
158-64eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00016-8journal_volume
243pub_type
杂志文章abstract::Memory processes may be independent, compete, operate in parallel, or interact. In accordance with this view, behavioral studies suggest that the hippocampus (HPC) and prefrontal cortex (PFC) may act as an integrated circuit during performance of tasks that require working memory over longer delays, whereas during sho...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.07.045
更新日期:2011-12-01 00:00:00
abstract::Animals reared in an enriched environment are less vulnerable to abuse-like behavior and exhibit less persistent drug seeking, perhaps due to a decrease in the incentive value of stimuli associated with reward. The present study investigated the effects of environmental enrichment on Pavlovian conditioned approach (PC...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.09.021
更新日期:2012-01-01 00:00:00
abstract::According to our previous work, mice of the same strain and age show striking inter-individual differences in behaviour when exposed to a T-maze test. Further, the animals exploring the maze slowly (slow mice) or staying at the starting point (freezing behaviour), which show high levels of emotionality/anxiety in othe...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00449-1
更新日期:2002-08-21 00:00:00
abstract::Attention to addiction of women alone for fetus and infant's health has caused the possible role of father's status was less considered, while some developmental impairments including decrease of liter size, weight loss, congenital deficiencies, behavioral disorders, and learning and memory impairments in offspring wi...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.07.041
更新日期:2008-01-10 00:00:00
abstract::During agonistic encounters, the perception of a larger opponent through morphological signaling typically suppresses aggression in the smaller individual, preventing contest intensity escalation. However, non-morphological factors such as central serotonin (5-HT) activity can influence individual aggression, potentia...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.07.028
更新日期:2015-10-01 00:00:00
abstract::Glutamate N-methyl-d-aspartate (NMDA) receptor antagonists, such as dizocilpine (MK-801), elicit schizophrenia-like symptoms in humans and a behavioral syndrome in rodents, characterized by hyperlocomotion and stereotyped actions, which is antagonized by antipsychotic drugs. Animal models of schizophrenia have been es...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.06.014
更新日期:2010-12-25 00:00:00
abstract::Blind pointing (i.e. pointing to visual targets without seeing the pointing arm) was investigated in normal subjects in response to stepwise lateral tilts (20 degrees) of the body, head, and trunk. Blind pointing positions of the right index finger on the outer surface of a hemispherical screen were measured relative ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90140-4
更新日期:1988-09-15 00:00:00
abstract::The current study examined sex differences in initial and subsequent strategies in solving a navigational problem within a virtual reality environment. We tested 163 undergraduates on a virtual T-maze task that included probe trials designed to assess whether participants were responding using either a place or respon...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.04.037
更新日期:2016-07-15 00:00:00
abstract::Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00207-8
更新日期:2001-09-14 00:00:00
abstract::Between April 2007 and December 2015, the Veterans Health Administration (VHA) screened one million combat veterans for traumatic brain injury (TBI), among 2.6 million deployed during operations Enduring Freedom, Iraqi Freedom and New Dawn (OEF/OIF/OND). Since 2007, among those reporting, screened and referred for def...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2016.08.036
更新日期:2018-03-15 00:00:00
abstract::This study examined ontogenetic differences in anticipatory 50 kHz ultrasonic vocalization (USV) production to social interactions in male Sprague-Dawley rats. Adults increased USVs across days when tested socially but not when left alone (Experiment 1), and displayed anticipatory USVs to return to the cage-mate (Expe...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.10.001
更新日期:2012-01-15 00:00:00
abstract::The present research studied the influence of an early chronic variable stress (CVS) paradigm - an animal model of depression - on behavioral responses to subsequent environmental challenges suggested to model anhedonia and emotional reactions such as anxiety and fear. In order to explore a potential involvement of an...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(00)00302-8
更新日期:2000-12-20 00:00:00
abstract::Inadequate sleep is a major health concern of modern societies in view of the increased morbidity and mortality rates from physiological disturbances, including compromised adaptive immune responses. Many studies investigated the effect sleep restriction (SR) on the normal immune response in terms of leukocyte number ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.01.019
更新日期:2019-04-19 00:00:00
abstract::Spatial discrimination learning in aged rats serves as an animal model of cognitive aging. We assessed the replicability of spatial discrimination performance in the standard Morris water escape task. To this end the learning curves and the performance in a probe trial of 24-month-old outbred Wistar (HsdWin:Wu) contro...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)02284-5
更新日期:1997-09-01 00:00:00
abstract::Compared to controls, bilateral forebrain injections of cycloheximide or glutamate in 2-day-old chicks resulted in significantly less activity in response to intraperitoneal injections of the dopaminergic agonist, apomorphine, or the cholinergic antagonist, scopolamine, when tested on stabilimeters four weeks later. T...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(82)90038-9
更新日期:1982-07-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvement of neuroinflammation and white matter abnormalities in psychiatric disorders and neurodegenerative diseases. Cuprizon...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.03.038
更新日期:2015-01-01 00:00:00
abstract::Recent work has found that behaviorally inhibited (BI) individuals exhibit enhanced eyeblink conditioning in omission and yoked training as well as with schedules of partial reinforcement. We hypothesized that spacing CS-US paired trials over a longer period of time by extending and varying the inter-trial interval (I...
journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2016.02.007
更新日期:2016-05-01 00:00:00
abstract::Taste recognition memory in rodents is evident as taste neophobia disappears upon repeated taste exposures without aversive consequences, thus increasing the consumption of familiar edibles. The attenuation of taste neophobia (AN) induced by taste familiarity is auditory context-dependent in mice since neophobia to a ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112687
更新日期:2020-08-05 00:00:00
abstract::Rats learned to discriminate between two degrees of roughness, detecting the stimuli only with their vibrissal system. After bilateral trimming of the vibrissae, performance abruptly dropped to chance levels and remained there throughout the period in which the vibrissae were kept trimmed. After the vibrissae regrew t...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(89)90011-9
更新日期:1989-01-01 00:00:00
abstract::The core symptoms of autism spectrum disorder (ASD) include deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Mouse models with behavioral phenotypes relevant to these core symptoms offer an experimental approach to advance the investigation of genes associated...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.06.025
更新日期:2010-12-25 00:00:00
abstract::Neuregulin 1 (NRG1) is an important growth factor involved in the development and plasticity of the central nervous system. Since its identification as a susceptibility gene for schizophrenia, several transgenic mouse models have been employed to elucidate the role NRG1 may play in the pathogenesis of psychiatric dise...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.05.008
更新日期:2011-10-31 00:00:00
abstract::Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seve...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00186-3
更新日期:2001-08-01 00:00:00
abstract::Although lesion studies suggest that the rat medial prefrontal cortex (mPFc) is involved in the process necessary for reversal of a particular set of contingencies, the nature of lesion-induced deficits is unclear. The involvement of rat mPFc in reversal of a simple spatial discrimination was examined in the present s...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2003.10.034
更新日期:2004-07-09 00:00:00
abstract::The present study investigated the effects of a single intravenous (i.v.) dose of Vitamin C (ascorbate, ASC) on spatial memory in APP/PSEN1 mice, an Alzheimer's disease model. First, we confirmed the uptake time course in ASC-depleted gulo (-/-) mice, which cannot synthesize ASC. Differential tissue uptake was seen ba...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.01.044
更新日期:2014-05-01 00:00:00
abstract::We analysed the execution of multijoint pointing movements in humans while weight or spring loads were applied to the pointing hand. Visual feedback on arm and hand position was excluded. Movement paths, final positions, and normalized velocity profiles were found to be load-independent, except for the very first move...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90106-o
更新日期:1990-12-21 00:00:00
abstract::This paper provides the first report of spatial learning in guinea pigs using the Morris water maze (MWM). Male and female guinea pigs were trained for 5 consecutive days (8 trials/day; acquisition phase) in either the visible (cued) or the hidden (non-cued) platform version of the MWM. In both tests, guinea pigs lear...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00188-7
更新日期:2001-09-28 00:00:00
abstract::We assessed early rearing conditions on aging-related changes in mouse behavior. Two isolated-housing groups, running wheel (IHRW) and empty cage (IHEC), were compared against two enriched environments, static (EEST) and dynamic (EEDY), both of which included toys and other mice. For EEDY, the location of toys and sou...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.007
更新日期:2016-04-01 00:00:00
abstract::Psychophysical procedures were used to investigate the effects observed by humans when two odorants were presented simultaneously through the same nostril (physical mixture) or separate nostrils (dichorhinic mixture). The odor pairs were (+)-limonene and alpha-pinene, (+)-limonene and propionic acid, alpha-pinene and ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(87)90157-4
更新日期:1987-11-01 00:00:00
abstract::Disuse of the paretic hand after stroke is encouraged by compensatory reliance on the nonparetic hand, to exacerbate impairment and potentially constrain motor rehabilitation efficacy. Rodent stroke model findings support that learning new unimanual skills with the nonparetic forelimb diminishes functional improvement...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112900
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory. METHODS:Memory performance was eval...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.02.003
更新日期:2013-05-15 00:00:00