当前位置： SCI文献检索 > BEHAVIOURAL BRAIN RESEARCH期刊下所有文献 > Systemic administration of anti-NGF antibodies to neonatal mice impairs 24-h retention of an inhibitory avoidance task while increasing ChAT immunoreactivity in the medial septum.

Systemic administration of anti-NGF antibodies to neonatal mice impairs 24-h retention of an inhibitory avoidance task while increasing ChAT immunoreactivity in the medial septum.

Abstract：

:Neonatal mice received subcutaneous injections of either antibody against murine NGF raised in goat (3 mg, injection volume 50 microliters) or preimmune serum on postnatal days 2, 4, 6, 8, 10, and 12. They were tested on postnatal days 15-16 or 20-21 for learning and 24-h retention of a passive avoidance step-through task. Immunostaining for choline acetyltransferase (ChAT) was measured in two cholinergic forebrain areas (septum and caudate-putamen) on postnatal day 16 or 21. Locomotor activity and exploratory behavior in an open-field test were also assessed on day 17 or 22, following a single administration of either scopolamine (2 mg/kg) or saline solution. While anti-NGF treatment did not affect acquisition on day 15, impairment in retention was evident on day 16. On days 20-21, no effects were found either on acquisition or on retention capabilities. Analysis of ChAT immunostaining revealed a significant increase of ChAT-immunopositive cells in the medial septal area in 16-day-old but not in 21-day-old mice. Behavior in the open-field test and age-typical response to scopolamine were not altered by anti-NGF at either of the two ages considered. These data support the view that immunological neutralization of endogenous NGF specifically affects the maturation of retention capabilities in altricial rodents, and confirm the involvement of forebrain cholinergic mechanisms in early memory processes.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Calamandrei G,Ricceri L,Valanzano A

doi

10.1016/0166-4328(95)00234-0

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

81-91

issue

2

eissn

0166-4328

issn

1872-7549

pii

0166432895002340

journal_volume

78

pub_type

杂志文章

相关文献

BEHAVIOURAL BRAIN RESEARCH文献大全
  • Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D- and L-carvone.

    abstract：:Carvone enantiomers (D and L optical isomers) have been shown to be discriminable by humans even though the odor qualities are quite similar. Our experiment is based on a finding (J. Steroid Biochem. Molec. Biol. 1991;39(4B):621) that Concanavalin A (ConA) applied to a frog olfactory epithelium preparation blocks cAMP...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(02)00242-5

    authors： Kirner A,Deutsch S,Weiler E,Polak EH,Apfelbach R

    更新日期：2003-01-22 00:00:00

  • Synaptic plasticity in the red nucleus and learning.

    abstract：:Pairing of the stimulus to the cerebral peduncle (CP) with that to the forearm skin leads cats to flex their forearms within a 10-day training period in response to stimulus to CP, which was initially ineffective. Behavioral study and extracellular unit analysis suggested that the cellular mechanism for this condition...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(88)90094-0

    authors： Murakami F,Oda Y,Tsukahara N

    更新日期：1988-04-01 00:00:00

  • Remote ischemic post-conditioning improves neurological function by AQP4 down-regulation in astrocytes.

    abstract：:Cerebral ischemia is a primary cause of human death and long-term disability. Previous studies have suggested that remote ischemic post-conditioning (RIPC) is a potential useful tool for cerebral ischemic treatment. However, the protective mechanism of RIPC is not very clear. This study verified the hypothesis that, i...

    journal_title：Behavioural brain research

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbr.2015.04.024

    authors： Li S,Hu X,Zhang M,Zhou F,Lin N,Xia Q,Zhou Y,Qi W,Zong Y,Yang H,Wang T

    更新日期：2015-08-01 00:00:00

  • Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression.

    abstract：:Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways affected by chronic stress in brain have not been fully explored. We invest...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.112053

    authors： Lu Q,Mouri A,Yang Y,Kunisawa K,Teshigawara T,Hirakawa M,Mori Y,Yamamoto Y,Libo Z,Nabeshima T,Saito K

    更新日期：2019-10-17 00:00:00

  • Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice.

    abstract：:Stressful life events and chronic stress are implicated in the development of depressive disorder in humans. Neuropeptide Y (NPY) and galanin have been shown to modulate the stress response, and exert antidepressant-like effects in rodents. To further investigate these neuropeptides in depression-like behaviour, NPY a...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2010.08.044

    authors： Christiansen SH,Olesen MV,Wörtwein G,Woldbye DP

    更新日期：2011-01-20 00:00:00

  • Metabolic syndrome accentuates post-traumatic stress disorder-like symptoms and glial activation.

    abstract：:The relationship between individuals with post-traumatic stress disorder (PTSD) and the development of metabolic syndrome (MS) is well understood, but the relationship between individuals with preexisting MS and the development of PTSD is not yet known. Therefore, we evaluated the course of PTSD development in preexis...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2020.112557

    authors： Alves Freire Ribeiro AC,Batista TH,Trujillo Rojas VC,Giusti-Paiva A,Cardoso Vilela F

    更新日期：2020-04-20 00:00:00

  • Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.

    abstract：:CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated, two-choice, operant task to discriminate 20.0 mg/kg CGS 10746B from its veh...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(95)00167-0

    authors： Meehan SM,Schechter MD

    更新日期：1996-01-01 00:00:00

  • Decreased proliferation in the adult rat hippocampus after exposure to the Morris water maze and its reversal by fluoxetine.

    abstract：:Granular cell proliferation in the adult hippocampus decreases during aging and after chronic stress, while it can be increased by physical activity or treatment with the antidepressant fluoxetine. We investigated whether the physical and cognitive stimulation accompanied by stress in the commonly used Morris water ma...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2005.04.013

    authors： Námestková K,Simonová Z,Syková E

    更新日期：2005-08-30 00:00:00

  • The association between NCAM1 levels and behavioral phenotypes in children with autism spectrum disorder.

    abstract：:Autism spectrum disorders (ASDs) are neuropsychiatric disorders associated with synaptic function and plasticity. Neural cell adhesion molecule (NCAM1) dysfunction impairs synapse formation, synaptic activity and plasticity. To explore the relationship between NCAM1 and ASD, a case-control study was conducted. This re...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2018.11.012

    authors： Yang X,Zou M,Pang X,Liang S,Sun C,Wang J,Fan L,Xia W,Wu L

    更新日期：2019-02-01 00:00:00

  • Changes in sleep-waking cycle after striatal excitotoxic lesions.

    abstract：:Huntington's disease (HD) patients show severe diurnal choreic movements, while during slow-wave sleep (SWS) abnormal movements subside. Sleep disturbances in HD, including irregular delta activity and decreases in SWS, have also been reported. Striatal excitotoxic lesions have been shown to induce increased nocturnal...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(02)00201-2

    authors： Mena-Segovia J,Cintra L,Prospéro-García O,Giordano M

    更新日期：2002-11-15 00:00:00

  • Persistent activation of select forebrain regions in aggressive, adolescent cocaine-treated hamsters.

    abstract：:Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates. The current study investigated whether adolescent cocaine exposure activated neurons in areas of hamster forebrain implicated in aggressive behavior by examining the expre...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2004.11.027

    authors： Knyshevski I,Connor DF,Harrison RJ,Ricci LA,Melloni RH Jr

    更新日期：2005-04-30 00:00:00

  • Examining the effect of online advertisement cues on human responses using eye-tracking, EEG, and MRI.

    abstract：:This study sought to emphasize how disciplines such as neuroscience and marketing can be applied in advertising and consumer behavior. The application of neuroscience methods in analyzing and understanding human behavior related to the Elaboration Likelihood Model (ELM) and brain activity has recently garnered attenti...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2021.113128

    authors： Yen C,Chiang MC

    更新日期：2021-01-15 00:00:00

  • The long-lasting effects of cross-fostering on the emotional behavior in ICR mice.

    abstract：:Early-life stress during the postnatal period could precipitate long-lasting alterations in the functional properties underlying emotional expression in humans, but how the psychological stress of cross-fostering affects emotional behavior during adulthood in mice remains primarily unknown. The purpose of the present ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2008.10.031

    authors： Lu L,Mamiya T,Lu P,Niwa M,Mouri A,Zou LB,Nagai T,Hiramatsu M,Nabeshima T

    更新日期：2009-03-02 00:00:00

  • 22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.

    abstract：:Ultrasonic vocalization (USV) was found useful for differentiating fear and anxiety in rats. These affective states were established through a Pavlovian conditioning procedure. Danger stimulus, preceding unavoidable tail shock, elicited acute fear. Intertrial situational cues evoked anxiety. A safety signal (SS) indic...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(02)00321-2

    authors： Jelen P,Soltysik S,Zagrodzka J

    更新日期：2003-04-17 00:00:00

  • Working and reference memory of pigs in the spatial holeboard discrimination task.

    abstract：:The present study investigated whether pigs are able to acquire a complex spatial holeboard discrimination task (4 of 16 holes baited) and whether mixing stress affects performance in this task. All pigs rapidly reduced the number of re-visits to baited holes (working memory) and to unbaited holes (reference memory). ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.06.014

    authors： Arts JW,van der Staay FJ,Ekkel ED

    更新日期：2009-12-14 00:00:00

  • Speeding up visual discrimination learning in cats by differential exposure of positive and negative stimuli.

    abstract：:We have developed an adaptive training method which considerably reduces the total time required to train cats to threshold in an orientation discrimination task. During training, the animals are given greater exposure in time to the positive stimulus compared to the negative one. Therefore, this method has been coine...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(90)90153-6

    authors： de Weerd P,Vandenbussche E,Orban GA

    更新日期：1990-01-01 00:00:00

  • Role of the D3 dopamine receptor in nicotine sensitization.

    abstract：:Adolescent cigarette use is associated with reduced quitting success and continued smoking in adulthood. Interestingly, polymorphisms of the dopamine D3 receptor (DRD3) gene have been associated with smoking behavior, and the receptor is expressed in an age- and brain region-dependent manner that suggests relevance to...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.04.025

    authors： Smith LN,Bachus SE,McDonald CG,Smith RF

    更新日期：2015-08-01 00:00:00

  • Aging and time-of-day effects on anxiety in female Octodon degus.

    abstract：:Animal models of anxiety have usually employed nocturnal species (e.g. rats and mice), and the tests used have been almost exclusively performed during the diurnal phase (lights on). Here, for the first time, we tested anxiety in a diurnal rodent, Octodon degus, according to its age (23 versus 40 months of age) and th...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.01.001

    authors： Popović N,Baño-Otálora B,Rol MA,Caballero-Bleda M,Madrid JA,Popović M

    更新日期：2009-06-08 00:00:00

  • A frontal attention mechanism in the visual mismatch negativity.

    abstract：:Automatic detection of environmental change is a core component of attention. The mismatch negativity (MMN), an electrophysiological marker of this mechanism, has been studied prominently in the auditory domain, with cortical generators identified in temporal and frontal regions. Here, we combined electroencephalograp...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.07.022

    authors： Hedge C,Stothart G,Todd Jones J,Rojas Frías P,Magee KL,Brooks JC

    更新日期：2015-10-15 00:00:00

  • Light experience and the development of behavioural lateralisation in chicks. II. Choice of familiar versus unfamiliar model social partner.

    abstract：:In late-stage embryos of domestic fowl, exposure of the right eye to light entering through the shell induces asymmetry of the thalamofugal visual pathway, together with differences in performance according to whether the right or left eye (RE, LE) is in use (Behav. Brain Res. 38 (1990) 211). Nevertheless, at least so...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2004.04.016

    authors： Andrew RJ,Johnston AN,Robins A,Rogers LJ

    更新日期：2004-11-05 00:00:00

  • Yohimbine reinstates extinguished 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) seeking in rats with prior exposure to chronic yohimbine.

    abstract：:Although exposure to acute stress has been shown to reinstate extinguished responding for a wide variety of drugs, no studies have investigated stress-induced reinstatement in animals with a history of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) self-administration. Thus, rats were trained to press a lever for M...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.07.056

    authors： Ball KT,Jarsocrak H,Hyacinthe J,Lambert J,Lockowitz J,Schrock J

    更新日期：2015-11-01 00:00:00

  • Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease.

    abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder, characterised by severe degeneration of basal ganglia, motor abnormalities, impaired cognitive function and emotional disturbances. Many of the distinct neuropathological features of HD are reproduced in rats by intrastriatal injections of the exci...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.10.004

    authors： Scattoni ML,Valanzano A,Pezzola A,March ZD,Fusco FR,Popoli P,Calamandrei G

    更新日期：2007-01-25 00:00:00

  • Long-term contextual memory in infant rats as evidenced by an ethanol conditioned tolerance procedure.

    abstract：:Conditioned tolerance can be conceptualized as a particular case of Pavlovian conditioning in which contextual cues play the role of the conditioned stimulus. Although the evidence is contradictory, it is frequently assumed that long-term contextual conditioning in pre-weanling rats is weak or even absent. This hypoth...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2017.06.007

    authors： Castelló S,Molina JC,Arias C

    更新日期：2017-08-14 00:00:00

  • Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats.

    abstract：:The present study was designed to investigate the possible role of perinatal androgens acting via the androgen receptor, as opposed to the estrogen receptor, for the differentiation of adult mounting and lordosis behavior in female rats. Female Wistar (W) and Sprague-Dawley (SD) rats were exposed to the anti-androgen ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(05)80238-4

    authors： Brand T,Slob AK

    更新日期：1991-07-01 00:00:00

  • The rat retrosplenial cortex as a link for frontal functions: A lesion analysis.

    abstract：:Cohorts of rats with excitotoxic retrosplenial cortex lesions were tested on four behavioural tasks sensitive to dysfunctions in prelimbic cortex, anterior cingulate cortex, or both. In this way the study tested whether retrosplenial cortex has nonspatial functions that reflect its anatomical interactions with these f...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2017.08.010

    authors： Powell AL,Nelson AJD,Hindley E,Davies M,Aggleton JP,Vann SD

    更新日期：2017-09-29 00:00:00

  • ZENK expression in a restricted forebrain area correlates negatively with preference for an imprinted stimulus.

    abstract：:Sexual imprinting is an early learning process by which young birds acquire the characteristics of a potential sexual partner. The physiological basis of this learning process is an irreversible reduction of dendritic spines in two forebrain areas, the LNM (lateral nido-mesopallium) and the MNM (medial nido-mesopalliu...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.03.034

    authors： Huchzermeyer C,Husemann P,Lieshoff C,Bischof HJ

    更新日期：2006-07-15 00:00:00

  • Neuroimaging the temporal dynamics of human avoidance to sustained threat.

    abstract：:Many forms of human psychopathology are characterized by sustained negative emotional responses to threat and chronic behavioral avoidance, implicating avoidance as a potential transdiagnostic factor. Evidence from both nonhuman neurophysiological and human neuroimaging studies suggests a distributed frontal-limbic-st...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2013.09.042

    authors： Schlund MW,Hudgins CD,Magee S,Dymond S

    更新日期：2013-11-15 00:00:00

  • Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice.

    abstract：:The effects of intracerebroventricular (i.c.v.) administration of ultra low doses (ULDs) of histamine, clobenpropit and pyrilamine are studied on morphine state-dependent (STD) memory in mice. Although pre-test administration of different doses of histamine and clobenpropit showed no effect on impairment of memory ind...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2005.07.014

    authors： Khalilzadeh A,Zarrindast MR,Djahanguiri B

    更新日期：2006-01-06 00:00:00

  • The role of the dorsomedial part of the prefrontal cortex serotonergic innervation in rat responses to the aversively conditioned context: behavioral, biochemical and immunocytochemical studies.

    abstract：:In this study we have explored differences in animal reactivity to conditioned aversive stimuli using the conditioned fear test (a contextual fear-freezing response), in rats subjected to the selective lesion of the prefrontal cortex serotonergic innervation, and differing in their response to the acute painful stimul...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2008.04.003

    authors： Lehner M,Taracha E,Turzyńska D,Sobolewska A,Hamed A,Kołomańska P,Skórzewska A,Maciejak P,Szyndler J,Bidziński A,Płaźnik A

    更新日期：2008-10-10 00:00:00

  • Schizophrenia-relevant behaviours in a genetic mouse model for Y2 deficiency.

    abstract：:Expression levels of neuropeptide Y (NPY) are changed in schizophrenia patients. However, the direction of changes to NPY expression and the mechanisms behind NPY's impact on the development of the illness is not understood in detail. Here we investigated whether alterations in Y2 activity may be involved in the devel...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.10.029

    authors： Karl T,Chesworth R,Duffy L,Herzog H

    更新日期：2010-03-05 00:00:00