Abstract：
:CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated, two-choice, operant task to discriminate 20.0 mg/kg CGS 10746B from its vehicle. CGS 10746B was highly discriminable, producing rapid acquisition of the discrimination, and its effects were dose-responsive allowing generation of an ED50 value of 6.16 mg/kg. Substitution tests were conducted with other typical and atypical antipsychotic compounds: haloperidol, chlorpromazine, clozapine and SCH 23390. Additional tests examined generalization from the CGS 10746B stimulus properties to the calcium channel blocker isradipine, as well as to the anticholinergics atropine, scopolamine and methylscopolamine, as well as to the serotonergic agonist DOI. Clozapine and SCH 23390 were the only substances to substitute for the CGS 10746B stimulus cue. Results are discussed in terms of potential D1 receptor selectivity of CGS 10746B.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Meehan SM,Schechter MDdoi
10.1016/0166-4328(95)00167-0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
199-205issue
1-2eissn
0166-4328issn
1872-7549pii
0166-4328(95)00167-0journal_volume
74pub_type
杂志文章abstract：:Regulation of CNS arousal is important for a wide variety of functions, including the initiation of all motivated behaviors. Usually studied with pharmacological or hormonal tools, CNS arousal can also be elevated by deep brain stimulation (DBS), in the human brain and in animals. The effectiveness of DBS is conventio...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：1988-09-15 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1993-12-20 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2019-06-03 00:00:00
