Abstract:
:NKP608 is a potent, selective and orally active non-peptidic neurokinin-1 (NK1)-receptor antagonist for which anxiolytic- and antidepressant-like effects have been described in various animal models in rats. Since species differences have been reported for some NK1-receptor antagonists, NKP608 was tested here in the social investigation test in gerbils, in a species in which the NK1-receptor is close to the human receptor. NKP608 (0.01 to> or =0.3 mg/kg p.o.) increased the time investigating the partner comparable to that seen following treatment with chlordiazepoxid (7 mg/kg p.o.), thus clearly indicating that NKP608 also has a robust anxiolytic effect in the social investigation test in gerbils. Such findings are in line with previous data obtained in rats, extend them to gerbils and corroborate the potential of NKP608 (and other representatives of the class of NK1-receptor antagonists) as new therapeutic agents beneficial in psychiatric disorders such as anxiety and/or depression.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Gentsch C,Cutler M,Vassout A,Veenstra S,Brugger Fdoi
10.1016/s0166-4328(02)00024-4subject
Has Abstractpub_date
2002-07-18 00:00:00pages
363-8issue
2eissn
0166-4328issn
1872-7549pii
S0166432802000244journal_volume
133pub_type
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