Abstract:
:Coca-paste (CP) is a drug of abuse that so far has not been extensively characterized. CP is an intermediate product of the cocaine alkaloid extraction process from coca leaves, hence it has a high content of cocaine base mixed with other chemical substances (impurities) and it is probably adulterated when it reaches the consumers. Despite its high prevalence and distribution through South America, little is known about its effects on the central nervous system. In the present study, a chemical analysis of CP samples from different police seizures was performed to determine the cocaine base content and the presence and content of impurities and adulterants. Some CP representative samples were selected to study the effects on the locomotor activity induced after acute systemic administration in rats as a measure of its stimulant action. The behavioral response was compared to equivalent doses of cocaine. As expected, cocaine was the main component in most of the CP samples assayed. Caffeine was the only active adulterant detected. Interestingly, several CP samples elicited a higher stimulant effect compared to that observed after cocaine when administered at equivalent doses of cocaine base. Combined treatment of cocaine and caffeine, as surrogate of different CP samples mimicked their stimulant effect. We demonstrated that cocaine and caffeine are the main components responsible for the CP-induced stimulant action while the contribution of the impurities was imperceptible.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
López-Hill X,Prieto JP,Meikle MN,Urbanavicius J,Abin-Carriquiry JA,Prunell G,Umpiérrez E,Scorza MCdoi
10.1016/j.bbr.2011.03.005subject
Has Abstractpub_date
2011-08-01 00:00:00pages
134-41issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00182-3journal_volume
221pub_type
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