Abstract：
:Autism is a heterogeneous, behaviorally defined developmental disorder with unknown etiology but thought to be the result of environmental insult acting upon the developing brain of a genetically susceptible individual. Approximately 30% of individuals with autism have normal development up to the age of about 30 months after which they experience behavioral regression and lose previously acquired motor, cognitive and social skills. Early post-natal toxicant administration to mice has been used to model autistic regression. To test the hypothesis that genetically altered mice might be more sensitive to toxicant exposure early in life, mice with a deletion of glutathione-S-transferaseM1 (GSTM1; a gene associated with increased risk of autism that codes for an enzyme involved in the management of toxicant-induced oxidative stress) and wild-type controls were exposed to valproic acid (VPA; a toxicant known to cause autism-like behavioral deficits that, in part, are mediated through oxidative stress) on post-natal day 14. VPA treatment caused significant increases in apoptosis in granule cells of the hippocampus and cerebellum. There was a genotype by treatment by sex interaction with wild-type females exhibiting significantly fewer apoptotic cells in these regions compared to all other groups. VPA treatment also resulted in long-lasting deficits in social behaviors and significant alterations in brain chemistry. VPA-treated GSTM1 knockout animals performed significantly fewer crawl-under behaviors compared to saline-treated knockout animals as well as wild-type controls receiving either treatment. Collectively, these studies indicate that VPA-treatment causes cerebellar and hippocampal apoptosis and that having the wild-type GSTM1 genotype may confer protection against VPA-induced neuronal death in female mice.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Yochum CL,Bhattacharya P,Patti L,Mirochnitchenko O,Wagner GCdoi
10.1016/j.bbr.2010.02.032subject
Has Abstractpub_date
2010-07-11 00:00:00pages
202-10issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00145-2journal_volume
210pub_type
杂志文章abstract：:We related fiber trajectory through the feline corpus callosum to the site of fiber origin in the cortical mantle and to functional modality. The cortical fields which contribute axons to the different portions of the corpus callosum were revealed by applying horseradish peroxidase (HRP) to the cut ends of selected gr...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)90116-3
更新日期：1994-10-20 00:00:00
abstract：:Rats were trained in a two-way active avoidance task followed immediately by a lateral hypothalamic intracranial self-stimulation (ICSS) treatment, during 5 consecutive days. The effects of the number of ICSS trains allowed (0, 500, 2500 or 4500) were studied upon acquisition and long-term retention (LTR, 10 and 30 da...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80007-5
更新日期：1991-02-28 00:00:00
abstract：:Amplitude and habituation of the acoustic startle response were assessed in four recombinant inbred (RI) rat strains. One group from each strain underwent repeated restraint stress, the last session of which was 24h before startle testing while, a second group from each strain was not stressed prior to testing. Additi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00061-5
更新日期：2003-09-15 00:00:00
abstract：:The nuclear complex of the horizontal limb of the diagonal band and the magnocellular preoptic nucleus, components of the basal forebrain magnocellular system affected in Alzheimer-type dementia, supply centrifugal innervation to the olfactory bulb. The lateral magnocellular preoptic nucleus provides significant GABAe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)89082-6
更新日期：1996-11-01 00:00:00
abstract：:We have previously demonstrated that kindling of the nucleus accumbens (NAc) induced psychosis relevant behaviors only after one, but not after five, stage-5 seizures, suggesting that five stage-5 NAc-evoked seizures antagonized psychosis relevant behaviors in rats. We hypothesized that brain opioid receptors are resp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.09.007
更新日期：2019-01-01 00:00:00
abstract：:Rodents housed with a running wheel can exhibit attenuated cocaine seeking and cocaine-induced psychomotor activation. However, the longevity of such a protection and the influence of the developmental stage during which exercise is displayed received little attention. Here, females and males C57BL/6J mice, aged 28 (a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.04.054
更新日期：2018-09-03 00:00:00
abstract：:Fetal Alcohol Syndrome (FAS) is associated with high rates of drug addiction in adulthood. One possible basis for increased drug use in this population is altered sensitivity to drug-associated contexts. This experiment utilized a rat model of FASD to examine behavioral and neural changes in the processing of drug cue...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.06.003
更新日期：2017-08-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90027-7
更新日期：1988-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.01.040
更新日期：2013-05-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(84)90197-9
更新日期：1984-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(84)90164-5
更新日期：1984-09-01 00:00:00
abstract：:Feeding and drinking behavior of rats maintained in constant light were recorded before, during and after feeding schedules with periods lying within or outside the range of circadian entrainment. Regardless of period, all schedules immediately resulted in the partial or complete synchronization of drinking behavior, ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(80)90045-5
更新日期：1980-02-01 00:00:00
abstract：:Nicotine has a broad spectrum of behavioural effects. A considerable body of data has emerged indicating genetic factors regulate the behavioural effects of nicotine. Experimental genetic techniques have been invaluable in generating knowledge on the interrelationship of genetic factors and behavioural responsiveness ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(00)00198-4
更新日期：2000-08-01 00:00:00
abstract：:Psychophysical procedures were used to investigate the effects observed by humans when two odorants were presented simultaneously through the same nostril (physical mixture) or separate nostrils (dichorhinic mixture). The odor pairs were (+)-limonene and alpha-pinene, (+)-limonene and propionic acid, alpha-pinene and ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(87)90157-4
更新日期：1987-11-01 00:00:00
abstract：:Prenatal restraint stress (PS) has been suggested as an attractive chronic model of anxiety. Here, we characterized the behavioral and autonomic responsivity to acute stress exposure in adult PS subjects. In Wistar rats, locomotor activity, as well as spontaneous behavior in an established animal model of anxiety, the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00273-5
更新日期：2003-03-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00274-1
更新日期：2001-11-01 00:00:00
abstract：:Hypoxia-ischemia (HI)-induced perinatal encephalopathy frequently causes chronic neurological morbidities and acute mortality. Bone mesenchymal stem cell (BMSC) transplantation could potentially promote functional and anatomical recovery of ischemic tissue. In vitro hypoxic preconditioning is an effective strategy to ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.05.055
更新日期：2017-08-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.08.011
更新日期：2008-01-25 00:00:00
abstract：:In this review I focus on how three methodological principles advocated by Philip Teitelbaum influenced my work to this day: that similar principles of organization should be looked for in ontogeny and recovery of function; that the order of emergence of behavioral components provides a view on the organization of tha...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2012.01.039
更新日期：2012-06-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90038-g
更新日期：1990-10-30 00:00:00
abstract：:The plasticity of the nervous system is illustrated in the many new neuronal connections that are formed during the acquisition of behavioral skills, loss of function after brain injury, and subsequent recovery of function. The present review describes the acquisition of skilled reaching, the act of reaching for food ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2007.12.026
更新日期：2008-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bbr.2018.08.006
更新日期：2019-01-01 00:00:00
abstract：:In the present study, we investigated how different processing stages involved in the perceptual analysis of biological motion (BM) are reflected by modulations in event-related potentials (ERP) in order to elucidate the time course and location of neural processing of BM. Data analysis was carried out using conventio...
journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.bbr.2004.06.025
更新日期：2005-02-28 00:00:00
abstract：:The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompa...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90168-7
更新日期：1983-04-01 00:00:00
abstract：:Amotivation is a major symptom of several psychiatric disorders. However, which specific motivations are most affected in various illnesses is not well understood. In major depressive disorder (MDD), anecdotal evidence suggests the motivation to explore may be especially affected, but direct evidence from either patie...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.09.055
更新日期：2017-01-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.12.032
更新日期：2015-04-01 00:00:00
abstract：:Spatial memory enables us to locate places and objects in space, to determine our position and manage spatial relationships in our environment. Our operations are displayed in a space that sometimes is inaccessible. In this case, the impossibility of movement within the context forces individuals to rely on the inform...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.03.022
更新日期：2018-07-16 00:00:00
abstract：:Systemic administration of dopamine (DA) D1 (SCH23390: SCH) and D2 (raclopride: RAC) antagonists blocked both acquisition and expression of fructose-conditioned flavor preferences (CFP). It is unclear what brain circuits are involved in mediating these effects. The present study investigated DA signaling within the nu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.05.004
更新日期：2012-08-01 00:00:00
abstract：:Elements of the septo-preoptic basal forebrain complex, particularly the lateral and medial septum, the diagonal band of Broca, and the magnocellular preoptic area, have been linked to medial forebrain bundle (MFB) self-stimulation. This study examines the roles of these areas in MFB self-stimulation by temporarily in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.12.005
更新日期：2007-03-12 00:00:00
abstract：:We examined the directionality of static and dynamic motor effects on cell discharge recorded during arm movements in motor cortex and area 5. Movements of 8 directions were performed by rhesus monkeys in a two-dimensional space ('movement task'). Static effects were determined using a static hold task in the same wor...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(85)90071-3
更新日期：1985-11-01 00:00:00
