Abstract：
:Amplitude and habituation of the acoustic startle response were assessed in four recombinant inbred (RI) rat strains. One group from each strain underwent repeated restraint stress, the last session of which was 24h before startle testing while, a second group from each strain was not stressed prior to testing. Additionally, prepulse inhibition of the acoustic startle response, and anxiety behavior in the elevated plus-maze were assessed in separate, non-stressed groups of each strain. In the non-stressed condition, these RI strains differed significantly from each other on all behaviors measured. In the two RI strains that showed the greatest habituation of the startle response, repeated stress resulted in significantly lower acoustic startle amplitude than that seen in non-stressed controls of those strains. In the strains showing low levels of habituation, repeated stressed increased the level. Neither genotype-dependent levels of startle amplitude, prepulse inhibition of the startle response, nor anxiety in the plus-maze were closely related to the effect of stress on either startle amplitude or habituation. The results suggest that genotype-dependent habituation of the startle response may be important in determining whether stress will alter startle amplitude.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Conti LH,Printz MPdoi
10.1016/s0166-4328(03)00061-5subject
Has Abstractpub_date
2003-09-15 00:00:00pages
11-8issue
1-2eissn
0166-4328issn
1872-7549pii
S0166432803000615journal_volume
144pub_type
杂志文章abstract：:This study assesses gender differences in spatial and non-spatial relational learning and memory in adult humans behaving freely in a real-world, open-field environment. In Experiment 1, we tested the use of proximal landmarks as conditional cues allowing subjects to predict the location of rewards hidden in one of tw...
journal_title：Behavioural brain research
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2008-01-10 00:00:00
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pub_type： 杂志文章
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更新日期：2016-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：2013-06-15 00:00:00
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更新日期：2017-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.01.021
更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-04-15 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-02-01 00:00:00
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更新日期：2012-10-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:Mesenchymal stem cell transplantation can regulate neuroinflammation and treat Alzheimer's disease (AD), but its effect is attenuated by in vitro expansion. To solve this problem, we used tanshinone IIA (TIIA)-incubated mesenchymal stem cells (MSCs) to treat neuroinflammation caused by amyloid β-protein (Aβ). Here, we...
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