Abstract：
:The nuclear complex of the horizontal limb of the diagonal band and the magnocellular preoptic nucleus, components of the basal forebrain magnocellular system affected in Alzheimer-type dementia, supply centrifugal innervation to the olfactory bulb. The lateral magnocellular preoptic nucleus provides significant GABAergic input. Since its stimulation may facilitate olfactory bulb mitral cells, we have investigated the effect of sub-total electrolytic lesions in this nucleus on performance in a simple test of olfactory investigation and its habituation. Two groups of rats used with lesions which occupied restricted volumes, approximately 30 and 15% of the magnocellular preoptic nucleus. Behaviorally, there was interference with olfactory investigation, with increased investigation latency and decreased investigation times, the group with larger lesions at 6 and 16 days after operation. There was no significant effect of the smaller lesions. No effects on patterns of olfactory habituation or discrimination were seen. The impairment of olfactory investigation could not be explained by interruption of medial forebrain bundle fibres traversing the nucleus. It is suggested that bilateral partial destruction of magnocellular preoptic neurones may produce significant deficits in either olfactory sensitivity or olfactory motivation.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Paolini AG,McKenzie JSdoi
10.1016/s0166-4328(96)89082-6subject
Has Abstractpub_date
1996-11-01 00:00:00pages
223-31issue
1-2eissn
0166-4328issn
1872-7549pii
S0166-4328(96)89082-6journal_volume
81pub_type
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journal_title：Behavioural brain research
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pub_type： 杂志文章
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