Abstract：
:Exposure to repeated stress can lead to diverse and widespread behavioral consequences, including reduction in food and water intake and subsequent diminution in weight gain. Many reports have suggested that repeated stress substantially alters the neurochemistry, morphology and physiology of neurons within the bed nucleus of the stria terminalis (BNST). Here we investigate the role of the BNST in mediating the reduced weight gain observed during repeated stress. Rats exposed to a one-week variate stress paradigm exhibited a reduction in weight gain over the course of the 7-day paradigm. Excitotoxic lesions to a subregion of the anterolateral BNST containing the oval nucleus had no effects early in the 7-day paradigm, but significantly attenuated the effects of repeated stress on weight gain by the last day of stress. These data suggest that at least two mechanisms mediate the effects of stress on body weight gain, and that when stressor exposure becomes repeated, the BNST is recruited, worsening the symptoms of stressor exposure.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Roman CW,Lezak KR,Kocho-Schellenberg M,Garret MA,Braas K,May V,Hammack SEdoi
10.1016/j.bbr.2011.11.010subject
Has Abstractpub_date
2012-02-01 00:00:00pages
300-4issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00795-9journal_volume
227pub_type
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