Abstract：
:Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 [39]) were conducted in 28 female PM-carriers (mean age: 41.32±8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61±8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kraan CM,Hocking DR,Georgiou-Karistianis N,Metcalfe SA,Archibald AD,Fielding J,Trollor J,Bradshaw JL,Cohen J,Cornish KMdoi
10.1016/j.bbr.2013.07.033subject
Has Abstractpub_date
2013-09-15 00:00:00pages
329-36eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00432-4journal_volume
253pub_type
杂志文章abstract：:Intracranial self-administration (ICSA) and intracranial place conditioning (ICPC) methodologies have been mainly used to study drug reward mechanisms, but they have also been applied toward examining brain reward mechanisms. ICSA studies in rodents have established that the ventral tegmental area (VTA) is a site supp...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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