Abstract：
:Placebo effects are the consequence of an interaction between an organism and its surroundings and may be influenced by cues from the environment. Our study was designed to analyze if conditioned auditory cues could trigger placebo effects and affect parkinsonian rigidity as measured by viscoelastic properties of skeletal muscles in patients treated with subthalamic stimulation. We found that after repeatedly associating with the effect of deep brain stimulation on rigidity, a common dial phone signal itself was able to reduce the mean values of viscoelastic stiffness in the placebo stage (368.8±50.4Nm(-1)) as compared to the stimulation-off conditions (383.7±61.2Nm(-1)) (q=4.18; p<0.05) in ten patients with Parkinson's disease. Thus, it appears that due to associative learning processes environmental cues can acquire the capacity to trigger placebo effects affecting the clinical status of the patients.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Rätsep T,Asser Tdoi
10.1016/j.bbr.2015.12.021subject
Has Abstractpub_date
2016-03-15 00:00:00pages
27-32eissn
0166-4328issn
1872-7549pii
S0166-4328(15)30330-2journal_volume
301pub_type
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