Abstract：
:Novelty and surprises differentially modify the left and right sides of the brain. Here we show that repeated brief exposures to the novelty of a non-home environment during infancy and early adulthood lead to long-lasting changes in adulthood in the global bi-lateralization organization of the brain as indexed by a transiently detectable right-sided orientating bias upon the initial encounter with the novel environment. Most surprisingly, we show that in the same individuals, the short-term effect of the combined neonatal and adulthood novelty exposures on functional brain asymmetry measured at young adulthood (5 months of age) is distinctively different from the long-term effect measured at late adulthood (15 months of age). These results suggest that long-lasting, cumulative effects of early life experience on brain and behavior organization are not necessarily permanent, but continue to unfold, presumably via interactions with a multitude of unmonitored intervening life events.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Tang AC,Reeb-Sutherland B,Yang Zdoi
10.1016/j.bbr.2011.02.047subject
Has Abstractpub_date
2011-08-01 00:00:00pages
91-7issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00163-Xjournal_volume
221pub_type
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