Abstract：
:These experiments examined the mnemonic functions of hippocampus and dorsal striatum in Pavlovian aversive conditioning. Rats were trained in a single session by presenting three paired tones and footshocks. Immediately after training, they were given microinjections of D-amphetamine or vehicle into either dorsal hippocampus or dorsal striatum. Twenty-four hours later conditioned freezing (measured as cessation of movement by infrared motion detectors) to the experimental context and to the tone were measured separately. Compared to vehicle injections, amphetamine injections into dorsal hippocampus significantly increased conditioned freezing to the context but not to the tone. Injections into dorsal striatum increased conditioned freezing to both the context and the tone. These results converge with findings from lesion experiments suggesting that hippocampus is involved in aversive conditioning with contextual CSs only, and that dorsal striatum is involved in aversive conditioning with both contextual and discrete cue CSs. The functions of the these two structures in relation to that of the amygdala in the mediation of conditioned freezing are discussed.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
White NM,Salinas JAdoi
10.1016/s0166-4328(02)00402-3subject
Has Abstractpub_date
2003-06-16 00:00:00pages
99-107issue
1-2eissn
0166-4328issn
1872-7549pii
S0166432802004023journal_volume
142pub_type
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journal_title：Behavioural brain research
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1995-11-01 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1998-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.08.008
更新日期：2007-01-10 00:00:00
