Abstract:
INTRODUCTION:In recent years, several investigations have related -hydroxy--methylbutyrate (HMB) to a reduced muscle proteolysis and to an increase in muscle mass. Therefore, a number of studies focused on the cellular and molecular mechanisms regulating these effects have been carried out. AIMS:The objectives of this review are: to know both HMB metabolism and toxicity, and to identify HMB cellular and molecular mechanisms of action when used as a dietary supplement. METHODS:A search was performed in the Web of Science, Pubmed and SportDiscus data bases. RESULTS were divided into two parts; this article presents aspects referring to HMB mechanisms of action. RESULTS:There is insufficient evidence that HMB intake increases muscle cholesterol synthesis. It probably has positive effects on muscle metabolism through both the mTOR and ubiquitin-proteasome pathways, although the mechanism of action is unknown. HMB may increase blood levels of -hydroxybutyrate and this could explain the main effects of HMB on muscle proteolysis. CONCLUSION:According to these results, the possibility of justifying the action of HMB through the beta-hydroxybutyrate pathway opens an interesting line of research for future studies. :Introducción: En los últimos años el -hidroxi--metilbutirato (HMB) ha sido foco de diversas investigaciones que le atribuyen un efecto sobre la disminución de la proteólisis muscular y un incremento de la masa muscular. Por tanto, se han realizado estudios centrados en los mecanismos celulares y moleculares responsables de dichos efectos. Objetivos: Los objetivos de la presente revisión son: conocer el metabolismo del HMB, así como su absorción y excreción; estudiar la posible toxicidad del HMB; e identificar los mecanismos celulares y moleculares de acción del HMB cuando se utiliza como suplemento nutricional. Métodos: Se utilizaron las bases de datos Web of Science, Pubmed y SportDiscus para realizar la búsqueda de artículos. Los resultados se dividieron en dos partes; en este artículo se presentan los resultados referentes a los mecanismos de acción del HMB. Resultados: No existen suficientes datos que apoyen que la ingesta de HMB incremente la síntesis de colesterol en el músculo. Es posible que existan efectos positivos en el metabolismo muscular a través de la vía mTOR y del sistema ubiquitin-proteasoma, aunque no se conoce su mecanismo de acción. Probablemente, el HMB eleva los niveles sanguíneos de hidroxibutirato y esto podría explicar sus principales efectos sobre la disminución de la proteólisis muscular. Conclusiones: De acuerdo a nuestros resultados, la posibilidad de justificar la acción del HMB a través de la vía del beta-hidroxibutirato abre una interesante línea de investigación para futuros estudios.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Manjarrez-Montes-de-Oca R,Torres-Vaca M,González-Gallego J,Alvear-Ordenes Idoi
10.3305/nh.2015.31.2.8437subject
Has Abstractpub_date
2014-11-27 00:00:00pages
597-605issue
2eissn
0212-1611issn
1699-5198journal_volume
31pub_type
杂志文章,meta分析,评审abstract:Introduction:Introduction: glutamine (GLN), the most abundant non-essential amino acid in the plasma, tends to be rapidly depleted in cells in situations of metabolic stress. Some studies have demonstrated the benefits of GLN supplementation on mortality, infection, and length of hospital stay. The objective of this re...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02949
更新日期:2020-07-13 00:00:00
abstract:OBJECTIVE:to identify what effect causes enteral nutrition on nutritional status of cancer. METHOD:a search was performed using the keywords "Cancer" AND "Enteral Nutrition" AND "Supplementation" in four document databases: Pubmed, EBSCO, ProQuest, and Web of Science. INCLUSION CRITERIA:age of the sample, major than ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2015.32.4.9227
更新日期:2015-10-01 00:00:00
abstract:OBJETIVE:to determine food patterns and its association with the consumption of various foods with nutritional status of Chilean university students of Nutrition and Dietetics. MATERIAL AND METHODS:cross-sectional study, 634 students were evaluated Nutrition and Dietetics at the Universidad San Sebastián, of Santiago,...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.4.9515
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:The satisfaction's analysis is being used as an instrument to create different sanitary reforms to improve the quality and numerous studies aim to the increase the mother's satisfaction directly related to the maternity care. OBJECTIVES:[corrected] Identify the woman satisfaction's degree about birth atte...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.3.6395
更新日期:2013-05-01 00:00:00
abstract::Obesity has become an important problem of public health in all developed countries. It has slightly different connotations in women because, apart from its greater prevalence, low socio-economic level is a risk factor solely for women. As well as a cardiovascular risk factor in women, it is associated with an increas...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
abstract:Introducción:las enfermedades cardiovasculares (EC) constituyen la principal causa de muerte a nivel mundial. La etiología es multifactorial, pueden influir diversos factores como la dieta, los hábitos de vida, el nivel de ejercicio físico o la carga genética. El gran número de genes implicados, así como sus diversas v...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.20960/nh.v33i1.23
更新日期:2016-02-16 00:00:00
abstract:INTRODUCTION:Dietary questionnaires usually only assess the intake of drinks that provide calories, but do not accurately evaluate total fluid or water intake. The evaluation of the fluid consumption pattern of a population has been the main objective of only a very few studies. OBJECTIVE:To evaluate the total fluid i...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.5.7421
更新日期:2014-05-01 00:00:00
abstract::The term "conditionally essential" (or semi-essential), initially applied to amino acids, has been generalized to other nutrients. A conditionally essential nutrient is a compound usually produced in adequate amounts by endogenous synthesis but that is exogenously required under certain circumstances. Thus, arginine, ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Various experimental studies have shown that a deficient intake of zinc increases the proliferation of cells, the effect of carcinogens and the progression of colonic adenomas to carcinomas. The purpose of our study is to determine whether this relationship between zinc intake deficit and co...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::This paper stems from the special lecture given by the author at 20th International Congress of Nutrition, held from 16 to 20 September 2013 in Granada (Spain), following for his appointment as "Living Legend" of the International Union of nutritional sciences (IUNS), in recognition of his outstanding contribution to ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.4.7205
更新日期:2014-04-01 00:00:00
abstract:UNLABELLED:Stability of extemporaneous parenteral nutrition is a critical aspect of these formulations, with impact in patient safety and quality of service. In lipid emulsions physical stability can be assessed by the increase in the number of lipid globules of size superior than 500 nm, generated by coalescence of sm...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000300014
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:Health inequality is the difference in incidence, prevalence, mortality, volume of diseases and other adverse sanitary conditions that exist between groups of specific populations. OBJECTIVES:To analyze the possible nutritional inequalities between two educational centers of Madrid to promote healthy habi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.1.6778
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:to compare the DSM Nutritional distributed in three states: normal, overweight and obese. SUBJECTS AND METHODS:test DSM "TEPSI" 58 children (intentional sample) from a total of 150, 4 to 4.5 years, which were divided into 3 groups was applied: normal weight (n = 28); overweight (n = 18) and obese (n = 12). W...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.1.9060
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:in relation to the student population, their class schedules, hours of study, budget shortages, among others, do not allow them to have good eating habits and sedentary ago. Within this context are the sports teams, which must deal with the above. OBJECTIVE:knowing the nutritional status of a group of col...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9877
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The maintenance of healthy lifestyles is of great importance to prevent pregnancy-related diseases at early stages. For this reason, the knowledge of the overall wellbeing of women at childbearing-age is necessary to provide appropriate advice to maintain or improve the nutritional status. The aim of this re...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.2.7082
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:The regular practice of physical activity (PA) has been associated with better health. In addition, job characteristics may determine the PA behaviours of employees, including the work shift. However, relatively few studies have examined the PA behaviour among shift workers. OBJECTIVE:This study aimed to ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.5.8628
更新日期:2015-05-01 00:00:00
abstract:Introduction:Introduction: child excess weight has been associated with obesity in adulthood and, as a consequence, increased risk of death due to cardiometabolic factors. Objective: to identify whether BMI reflects changes in the content and distribution of fat/adipose tissue and the cardiometabolic risk in children b...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.2071
更新日期:2019-04-10 00:00:00
abstract:BACKGROUND:Chile has drastically altered eating patterns and physical activity. The main nutritional problem faced by Chilean society is overweight, which arises progressively from an early age. The aim of this study is to determine the nutritional status and compare fitness levels and fasting glucose in students. PAT...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.6.8932
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:southern European, Middle Eastern, and North African countries bordering the Mediterranean share dietary habits characterized by moderation and a variety of foods, notably fruit and vegetables. These customs are becoming modified due to social and economic changes. An adequate intake of water and other dri...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9892
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:We may define Modular Parenteral Nutrition (MPN) as parenteral nutrition (PN) mixtures obtained from adding different macronutrients to standard formulations (SPN) both binary (amino acids and glucose) and ternary (amino acids, lipids, and glucose). OBJECTIVES:The aim of this study is to demonstrate that ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract:UNLABELLED:Nutritional management is essential in anorexia nervosa (AN), although nutrient replenishment must be done progressively to prevent the occurrence of re-alimentation syndrome. OBJECTIVE:to compare resting enengy expenditure (REE) by means of indirect calorimetry and by different equations in AN female patie...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::The build up of cholesterol in the atheromas is caused by, among other things, a disequilibrium of certain plasmatic lipoproteins. Food components which modify the levels of these lipoproteins can be considered as "atherogenic". Other components influence platelet activity and can be considered "thrombogenic". The sat...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:1995-05-01 00:00:00
abstract:Introduction:Objective: to identify cytokines and to associate them with several indexes of total and central adiposity in young female undergraduate students. Methods: 58 young female sophomore students, aged 18 to 25 years, from a Brazilian public university were evaluated. Both anthropometric measures (weight, heigh...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02860
更新日期:2020-04-16 00:00:00
abstract:INTRODUCTION:The prevalence of obesity, a serious public health problem, is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood. OBJECTIVE:To provide a systematic review of the best evidence about the effect of sibutramine and orlistat in weight loss, quality of life ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.1590/S0212-16112011000300004
更新日期:2011-05-01 00:00:00
abstract::Sustainability represents a major concern in recent years due to climate change pressure. The diet itself contribute to the emission of greenhouse gasses, water and land use, energy consumption and environment contamination. The Mediterranean diet should be understood not only as a set of foods but also as a cultural ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.2133
更新日期:2018-06-12 00:00:00
abstract::Introducción: el trastorno por atracón o "Binge Eating Disorders" (BED) se caracteriza por el consumo de grandes cantidades de comida en un breve periodo de tiempo acompañado de una sensación de falta de control sobre la ingesta. El BED se relaciona con una alimentación poco equilibrada, contribuyendo a la aparición d...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.799
更新日期:2016-11-29 00:00:00
abstract:OBJECTIVES:To evaluate the organoleptic characteristics of two specific nutritional supplements for diabetes (Glucerna SR and Resource Suport) and compare them. SETTING:An evaluation was made of 456 patients with Type 2 diabetes (most of them receiving OADs or insulin) from 34 centers. They were non-smoking elderly pa...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-09-01 00:00:00
abstract::Phospholipids are amphipathic lipids, which are found in all the cell membranes, organized as a lipid bilayer. They belong to the glycerol-derived lipids, showing a similar structure as triglycerides. The current interest of them comes from its effectiveness to incorporate different fatty acids in the cell membrane, a...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.31.1.7961
更新日期:2014-09-12 00:00:00
abstract::Diet, along with lifestyle factors, is an important determinant of the health status of an individual and of a community. Dietary assessment at the population level provides us with key information on the frequency and distribution of possible inadequate diets and/or nutritional status. It is also useful as input into...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.31.sup3.8750
更新日期:2015-02-26 00:00:00
abstract::Introducción: a escala mundial y nacional se reporta una alta prevalencia de sobrepeso y obesidad en menores de 5 años. La etiología es multifactorial, pero factores ambientales como sedentarismo y el progresivo deterioro de la alimentación promueven el exceso de peso y conllevan a mayor riesgo de enfermedades crónica...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.566
更新日期:2016-09-20 00:00:00