Tocopherol efficacy and safety for preventing retinopathy of prematurity: a randomized, controlled, double-masked trial.

Abstract:

:To test the efficacy and safety of vitamin E in preventing retinopathy of prematurity, 287 infants with birth weights of less than 1.5 kg or gestational ages of less than 33 weeks were enrolled within 24 hours of birth in a randomized, double-masked trial of IV, followed by oral, placebo v tocopherol (adjusted to plasma levels of 3 to 3.5 mg/dL). In the 196 infants completing ophthalmic follow-up, tocopherol did not prevent retinopathy of prematurity of any stage (28% placebo treated v 26% tocopherol treated) or moderately severe retinopathy of prematurity (8% placebo treated v 11% tocopherol treated). Cicatricial sequelae were not significantly different (1/97 placebo treated v 3/99 tocopherol treated), with one placebo-treated infant and one tocopherol-treated infant having retinal detachments. Among all 232 infants examined, those treated with tocopherol had more retinal hemorrhage than placebo-treated infants (8/121 placebo treated v 16/111 tocopherol treated), and retinal hemorrhage correlated positively (P less than .01) with plasma levels of tocopherol after the first 2 weeks of age. Prospective monitoring of morbidity including late-onset sepsis, necrotizing enterocolitis, etc revealed no differences between groups except that grades 3 and 4 intraventricular hemorrhage occurred more frequently in infants weighing less than 1 kg at birth who had received tocopherol (14/42, 33%) v those who had received placebo (4/43, 9%) (P less than .02). Our data do not support the use of tocopherol for prophylaxis against retinopathy of prematurity in premature infants and suggest that IV tocopherol treatment starting on day 1 may increase the incidence of hemorrhagic complications of prematurity, particularly in infants with birth weights of less than 1 kg.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Phelps DL,Rosenbaum AL,Isenberg SJ,Leake RD,Dorey FJ

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

489-500

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

79

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVES:To determine the association between parenteral antibiotic duration and outcomes in infants ≤60 days old with bacteremic urinary tract infection (UTI). METHODS:This multicenter retrospective cohort study included infants ≤60 days old who had concomitant growth of a pathogen in blood and urine cultures at 11...

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    doi:10.1542/peds.2018-3844

    authors: Desai S,Aronson PL,Shabanova V,Neuman MI,Balamuth F,Pruitt CM,DePorre AG,Nigrovic LE,Rooholamini SN,Wang ME,Marble RD,Williams DJ,Sartori L,Leazer RC,Mitchell C,Shah SS,FEBRILE YOUNG INFANT RESEARCH COLLABORATIVE.

    更新日期:2019-09-01 00:00:00

  • Pilot interferon-beta trial in children with chronic hepatitis B who had previously not responded to interferon-alpha therapy.

    abstract:BACKGROUND:Recombinant interferon alpha (IFN-alpha) treatment is useful in 40% of children with chronic hepatitis B. However, nonresponder children continue to have viral replication and a progressive disease. OBJECTIVE:To administer natural IFN-beta to hepatitis B virus chronic carrier children who had not responded ...

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    doi:10.1542/peds.99.2.222

    authors: Ruíz-Moreno M,Fernández P,Leal A,Bartolomé J,Castillo I,Oliva H,Carreño V

    更新日期:1997-02-01 00:00:00

  • Management of congenital adrenal hyperplasia using serum dehydroepiandrosterone sulfate and 17-hydroxyprogesterone concentrations.

    abstract::Simultaneous serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) and 17-hydroxyprogesterone (17-OHP) were compared with urinary 17-ketosteroid (17-KS) and pregnanetriol (PT) excretion during therapy in 18 prepubertal patients with the 21-hydroxylase deficiency form of congenital adrenal hyperplasia (CAH). ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Golden MP,Lippe BM,Kaplan SA,Lavin N,Slavin J

    更新日期:1978-06-01 00:00:00

  • Developmental changes in energy expenditure and physical activity in children: evidence for a decline in physical activity in girls before puberty.

    abstract:OBJECTIVE:To examine individual changes in energy expenditure and physical activity during prepubertal growth in boys and girls. METHODS:Total energy expenditure (TEE), resting energy expenditure, physical activity-related energy expenditure, reported physical activity, and fat and fat-free mass were measured three ti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.887

    authors: Goran MI,Gower BA,Nagy TR,Johnson RK

    更新日期:1998-05-01 00:00:00

  • Effects of polycythemia and hyperviscosity on cutaneous blood flow and transcutaneous PO2 and PCO2 in the neonate.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Waffarn F,Tolle CD,Huxtable RF

    更新日期:1984-09-01 00:00:00

  • The epidemiology of Staphylococcus aureus in a newborn nursery from 1970 through 1976.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hargiss C,Larson E

    更新日期:1978-03-01 00:00:00

  • Weight and menstrual function in patients with eating disorders and cystic fibrosis.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Weltman EA,Stern RC,Doershuk CF,Moir RN,Palmer K,Jaffe AC

    更新日期:1990-03-01 00:00:00

  • Lavage treatment of distal intestinal obstruction syndrome in children with cystic fibrosis.

    abstract::The efficacy, adverse reactions, and long-term effects of intestinal lavage treatment with a balanced electrolyte solution (Golytely) was evaluated in patients with cystic fibrosis and distal intestinal obstruction syndrome. Twenty-two patients with cystic fibrosis (mean age 21.8 years, range 14 to 34 years, 15 boys o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Koletzko S,Stringer DA,Cleghorn GJ,Durie PR

    更新日期:1989-05-01 00:00:00

  • Fatal myocardial infarction following therapy with prothrombin complex concentrates in a young man with hemophilia A.

    abstract::A fatal myocardial infarction in a 22-year-old man with hemophilia A and a factor VIII inhibitor is described. The catastrophic event occurred while the patient was receiving high doses of unactivated prothrombin complex concentrates. Autopsy examination revealed myocardial hemorrhage with no evidence of coronary arte...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sullivan DW,Purdy LJ,Billingham M,Glader BE

    更新日期:1984-08-01 00:00:00

  • Economic evaluation of the US Environmental Protection Agency's SunWise program: sun protection education for young children.

    abstract:OBJECTIVE:The SunWise School Program is a school-based sun safety education program that was developed by the US Environmental Protection Agency and aims to teach children how to protect themselves from overexposure to the sun. The objectives of this study were to assess the health benefits of the SunWise School Progra...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1400

    authors: Kyle JW,Hammitt JK,Lim HW,Geller AC,Hall-Jordan LH,Maibach EW,De Fabo EC,Wagner MC

    更新日期:2008-05-01 00:00:00

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    abstract::Attempts to correlate developmental outcome with medical complications affecting the fetus and infant have focused on the prenatal, intrapartum, and postnatal periods. The time beyond the newborn stage has not been explored in detail. The aim of this study was to relate events occurring during the gestational and neon...

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    pub_type: 杂志文章

    doi:10.1542/peds.61.3.470

    authors: Littman B,Parmelee AH Jr

    更新日期:1978-03-01 00:00:00

  • Noise and light exposures for extremely low birth weight newborns during their stay in the neonatal intensive care unit.

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    pub_type: 杂志文章

    doi:10.1542/peds.2007-3418

    authors: Lasky RE,Williams AL

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0297

    authors: Mitchell WG,Tseng-Ong L

    更新日期:2005-09-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Whitaker RC,Wright JA,Finch AJ,Psaty BM

    更新日期:1993-06-01 00:00:00

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    doi:10.1542/peds.108.4.e62

    authors: Lahiri T,Waltz DA

    更新日期:2001-10-01 00:00:00

  • Parental knowledge about antibiotic use: results of a cluster-randomized, multicommunity intervention.

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    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2006-2600

    authors: Huang SS,Rifas-Shiman SL,Kleinman K,Kotch J,Schiff N,Stille CJ,Steingard R,Finkelstein JA

    更新日期:2007-04-01 00:00:00

  • Ammonia encephalopathy secondary to urinary tract infection with Proteus mirabilis.

    abstract::Hyperammonemia with coma, tachypnea, and respiratory alkalosis developed in a 3-year-old boy with prune"-belly syndrome during a urinary tract infection with Proteus mirabilis. Hyperammonemia is thought to have resulted from the production within the massively dilated urinary tract of excessive amounts of ammonia due ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Samtoy B,DeBeukelaer MM

    更新日期:1980-02-01 00:00:00

  • Proteolysis associated with insulin resistance in cystic fibrosis.

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    pub_type: 杂志文章

    doi:10.1542/peds.101.3.433

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    更新日期:1998-03-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

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    更新日期:1994-12-01 00:00:00

  • Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol.

    abstract::In summary: (1) Colestipol therapy plus diet reduced total cholesterol 19 +/- 3% in 11 hypercholesterolemic children after two months and 13 +/- 5% after two years in five children. (2) Diet therapy did not significantly reduce serum concentration of any of the fat-soluble vitamins or folate. (3) During 24 months of c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Schwarz KB,Goldstein PD,Witztum JL,Schonfeld G

    更新日期:1980-02-01 00:00:00

  • Stakeholder Perspectives on Research and Practice in Autism and Transition.

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    doi:10.1542/peds.2016-4300F

    authors: Kuo AA,Crapnell T,Lau L,Anderson KA,Shattuck P

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    doi:10.1542/peds.111.2.402

    authors: Albers AB,Biener L

    更新日期:2003-02-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章,评审

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    更新日期:1984-12-01 00:00:00

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    authors: Uzel G,Premkumar A,Malech HL,Holland SM

    更新日期:2000-10-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.1.e10

    authors: Fox LM,Gerber MA,Penix L,Ricci A Jr,Hyams JS

    更新日期:1999-01-01 00:00:00

  • Deep venous thrombosis complicating myelomeningocele: report of three cases.

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    pub_type: 杂志文章

    doi:

    authors: Bernstein ML,Esseltine D,Azouz EM,Forbes P

    更新日期:1989-11-01 00:00:00

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