Abstract:
OBJECTIVE:Although invasive pneumococcal disease is infrequent in cystic fibrosis (CF), it is recommended that all patients with CF receive pneumococcal immunization. As part of a comprehensive program to immunize our clinic population, we obtained preimmunization anti-pneumococcal antibody levels. We hypothesized that the percentage of CF patients without protective levels of anti-pneumococcal antibody levels would be high, as they are exposed to frequent antibiotic therapy that may eradicate organisms before generation of an antibody response. METHODS:An observational study of 100 patients with CF, aged 1 to 39 years, was conducted in a regional CF center. Preimmunization anti-pneumococcal antibody levels against 6 serotypes were measured by enzyme-linked immunosorbent assay. Protective antibody levels were defined as >200 ng/mL. RESULTS:A majority of CF patients-61% to 100%, depending on age and serotype-had protective levels of pneumococcal antibody. There was a significant positive correlation between antibody level and age for 5 of the 6 serotypes tested. CONCLUSIONS:In contradistinction to our hypothesis, the majority of CF patients have protective preimmunization anti-pneumococcal antibody levels. However, a significant proportion-between 17% and 39%, depending on the serotype-did not exhibit adequate levels. Therefore, we concur with current recommendations for pneumococcal immunization in CF.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Lahiri T,Waltz DAdoi
10.1542/peds.108.4.e62subject
Has Abstractpub_date
2001-10-01 00:00:00pages
E62issue
4eissn
0031-4005issn
1098-4275journal_volume
108pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:BACKGROUND AND OBJECTIVES:Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome....
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0796
更新日期:2012-01-01 00:00:00
abstract::A 4-month-old boy with past medical history of eczema presented with fever and cough; a chest radiograph showed lung consolidation, and he was initially treated with amoxicillin for presumed community-acquired pneumonia. After several days, his fever persisted. He was also profoundly anemic. Antibiotic coverage was br...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-3856
更新日期:2015-07-01 00:00:00
abstract::This is a summary of the presentation on airway clearance in neuromuscular disorders presented as part of the program on airway clearance in Duchenne muscular dystrophy at the 30th annual Carrell-Krusen Neuromuscular Symposium on February 20, 2008. ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-2952G
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of domestic violence against mothers in a pediatric emergency department and the relationship of their children to the abusers. DESIGN:Cross-sectional survey of a convenience sample of mothers seeking treatment for their children. SETTING:An urban pediatric emergency department. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.5.1007
更新日期:1999-05-01 00:00:00
abstract::We have studied the epidemiology of inguinal hernias in preterm infants. Inguinal hernias occur with increased frequency in infants less than or equal to 32 weeks' gestational age or less than or equal to 1,250 g birth weight. Among infants less than or equal to 32 weeks' gestational age, intrauterine growth retardati...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract::A ganglioneuroblastoma developed in a 35-month-old boy with both the fetal hydantoin and fetal alcohol syndromes. Our case, plus two recent reports in the literature, would very likely establish the relationship between fetal hydantoin syndrome and the development of neural crest tumors. Infants exposed in utero to hy...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract:OBJECTIVES:This study was conducted to assess the impact of an interactive seminar based on self-regulation theory on 1) the treatment practices and communications and education behavior of physicians, 2) the health status and medical care utilization of their pediatric patients with asthma, and 3) the satisfaction wit...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.101.5.831
更新日期:1998-05-01 00:00:00
abstract::We describe our experience with blowgun dart aspiration via an illustrative case series and review the resources available to teach children how to construct these objects. A 15-year-old boy presented with cough, wheeze, and eventually admitted to aspiration of a homemade blowgun dart. This instance heightened the awa...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2012-3340
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Little is known about the impact of providing health insurance to uninsured children who have asthma or other chronic diseases. OBJECTIVES:To evaluate the association between health insurance and the utilization of health care and the quality of care among children who have asthma. DESIGN:Before-and-during...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:2-methylbutyryl-CoA dehydrogenase deficiency, also known as short/branched-chain acyl-CoA dehydrogenase (SBCAD) deficiency, is a recently described autosomal recessive disorder of L-isoleucine metabolism. Only 4 affected individuals in 2 families have been described. One patient developed athetoid cerebral pa...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.112.1.74
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:Recommendations to prevent vertical transmission of group B Streptococcus (GBS) infections have resulted in many women's receiving antibiotics during labor with an associated reduction in early-onset GBS infections in their newborn infants. However, a potential relationship of intrapartum antibiotics (IPA) to...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2421
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:We sought to evaluate the association between early protein and energy intake and neurodevelopment and growth of extremely low birth weight (<1000 g) infants. STUDY DESIGN:Daily protein and energy intakes were collected by chart review for the first 4 weeks of life on 148 extremely low birth weight survivors...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0211
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Studies of US adolescents have linked exposure to movie smoking with smoking behavior. It is unclear whether European adolescents are also responsive to movie tobacco imagery. METHODS:A longitudinal study was conducted to assess exposure to movie smoking in 2711 German never-smokers (aged 10 to 16 years). Mo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1201
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To determine the sensitivity, specificity, predictive value, and accuracy of a program of pulse oximetry screening of asymptomatic newborns for critical congenital cardiovascular malformation (CCVM). METHODS:Pulse oximetry was performed on asymptomatic newborns in the well-infant nurseries of 2 hospitals. Ca...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.3.451
更新日期:2003-03-01 00:00:00
abstract::A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVE:To study the relationship between disabling conditions and registration for child abuse and neglect in a 19-year whole-population birth cohort. SETTING:West Sussex area of the United Kingdom. STUDY DESIGN:Retrospective whole-population cohort. MAIN OUTCOMES:Child-protection registration, physical abuse, se...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1882
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To examine the impact of admission-day illness severity on nosocomial bacteremia risk after consideration of traditional risk determinants such as birth weight and length of stay. METHODS:The hospital courses for 302 consecutive very low birth weight (less than 1500 g) infants admitted to two neonatal intens...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Depression in childhood and adolescence is common and often persists into adulthood. This study assessed the population-level cost-effectiveness of a preventive intervention that screens children and adolescents for symptoms of depression in schools and the subsequent provision of a psychologi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-1823
更新日期:2012-03-01 00:00:00
abstract:CONTEXT:The effect of diabetes during pregnancy on the cognitive development of offspring is unclear because of inconsistent findings from limited studies. OBJECTIVE:This review was aimed to provide the best available scientific evidence on the associations between maternal pregnancy diabetes and the cognitive develop...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2015-4234
更新日期:2016-05-01 00:00:00
abstract::In addition to occasional autoimmune hemolytic anemia, unexplained iron-deficiency anemia has been reported in childhood Castleman disease (CD). The recent discovery of hepcidin has regenerated the research on iron metabolism. This hormone is a key regulator of iron homeostasis, mainly by inhibiting intestinal iron ab...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1123
更新日期:2010-12-01 00:00:00
abstract::Dietary patterns and racial differences in nutrient intake were observed in children 6 months to 4 years of age in the Bogalusa Heart Study. Even in this sample of young children, the composition of the intakes of the majority of children was not compatible with prudent recommendations of less than 35% and 10% of ener...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVES:There is no safe or risk-free level of tobacco use or tobacco smoke exposure. In this randomized controlled trial, we tested a tobacco control intervention in families and specifically evaluated a tailored cessation intervention for the parents and/or caregivers (Ps/Cs) who were smokers while their children ...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2017-1026M
更新日期:2018-01-01 00:00:00
abstract::A 17-year-old male subject with a history of deep venous thrombosis presented with acute unilateral severe chest pain. His examination was nonspecific, and vital signs were normal. His initial laboratory evaluation revealed mild thrombocytopenia, elevated troponin levels, and critically elevated activated partial thro...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0794
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this work was to determine whether visual impairment caused by toxoplasmic chorioretinitis is associated with impaired performance of specific tasks on standardized tests of cognitive function. If so, then we worked to determine whether there are patterns in these difficulties that provide a l...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1530
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:We have used the combination of midazolam, a short-acting benzodiazepine, and ketamine, a "dissociative anesthetic," to provide conscious sedation for invasive or lengthy procedures. METHODS:A total of 350 procedures (74 lumbar punctures, 97 bone marrow aspirations or biopsies, 84 radiotherapy sessions, and ...
journal_title:Pediatrics
pub_type: 临床试验,评论,杂志文章
doi:10.1542/peds.99.3.427
更新日期:1997-03-01 00:00:00
abstract::As newer treatment modalities become available for patients with severe lupus nephritis, it becomes increasingly important to identify patients at risk for renal failure. In this study, the records of 90 children presenting with systemic lupus erythematosus over a 13-year period were reviewed. Nineteen were lost to fo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on re...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0948
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:Adverse childhood experiences (ACEs) may have long-term consequences on at-risk behaviors that lead to an increased risk of sexually transmitted diseases (STDs) during adulthood. Therefore, we examined the relationship between ACEs and subsequent STDs for both men and women. METHODS:A total of 9323 (4263 men...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.1.e11
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the effect of left-to-right shunting on the resting energy expenditure (REE), total energy expenditure (TEE), and energy intake in a group of 3- to 5-month-old infants with moderate to large unrepaired ventricular septal defects (VSDs) compared with age-matched, heal...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.5.1172
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVES:To analyze, in extremely low birth weight infants, associations between peak bilirubin concentration and evidence of brain damage, and between peak bilirubin concentration and blindness attributable to retinopathy of prematurity. METHODS:Retrospective study of 128 infants of =800 g birth weight and =27 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.6.1426
更新日期:1998-12-01 00:00:00