Respiratory syncytial virus infection in patients with phagocyte defects.

Abstract:

:Patients with phagocyte defects frequently develop bacterial or fungal pneumonias, but they are not considered to be at increased risk for viral infections. We describe 3 patients with known phagocyte immunodeficiencies who developed lower respiratory tract infections (LRTI) caused by respiratory syncytial virus (RSV). All 3 patients had dense pneumonias as indicated by computed tomography scan of the lungs and RSV was recovered. We conclude that RSV can present as a dense pneumonia in patients with phagocyte defects. Along with common pathogens causing LRTI, RSV should be considered in the differential diagnosis. Viral cultures as well as rapid antigen detection assays for respiratory viruses should be included in the evaluation of LRTI in patients with phagocyte defects. respiratory syncytial virus, phagocyte, immunodeficiency, pneumonia.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Uzel G,Premkumar A,Malech HL,Holland SM

doi

10.1542/peds.106.4.835

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

835-7

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

106

pub_type

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