Mother-to-child transmission of human immunodeficiency virus type 1: risk of infection and correlates of transmission.

Abstract:

:One thousand eight hundred eighty-seven children born to human immunodeficiency virus type 1 (HIV-1) seropositive mothers, including 1045 infants prospectively followed up from birth, were studied. Intravenous drug use was the most frequent maternal risk factor, although the percentage of women infected by sexual contact increased from 5.8% in 1985 to 28.5% in 1990. Of the 551 first children followed up from birth and older than 15 months of age, 101 (18.3%) acquired infection and seroconverted to HIV-1. Another 31 (5.6%) asymptomatic seronegative children showed the presence of viral markers, for an apparent mother-to-offspring transmission rate of 23.9%. Overlapping results were seen in 22 second-born children followed up from birth. Of 59 sibships with definite infection status, when the first child was infected, 14 (40%) of 35 second children were infected, whereas when the first child was not infected, only 2 of 24 (8.3%) second children were infected. Discordance in HIV-1 transmission was found in 1 of 18 pairs of twins. Univariate and multivariate analyses of possible risk factors for HIV-1 transmission performed on the entire population of children and in the cohort of those followed up from birth were basically in agreement in indicating that the development of symptoms in the mother before delivery and breast-feeding (indeed adopted in only 22 infants in whom HIV-1 infection was identified at birth) were significantly and independently associated with a higher transmission rate. In addition, girls were more frequently infected than boys.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatrics

journal_title

Pediatrics

authors

Gabiano C,Tovo PA,de Martino M,Galli L,Giaquinto C,Loy A,Schoeller MC,Giovannini M,Ferranti G,Rancilio L

subject

Has Abstract,Author List Incomplete

pub_date

1992-09-01 00:00:00

pages

369-74

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

90

pub_type

杂志文章
  • Improving Access to Care at Autism Treatment Centers: A System Analysis Approach.

    abstract:OBJECTIVE:The prevalence of autism spectrum disorder is steadily increasing and placing more demands on already overburdened diagnostic and treatment systems. A thoughtful, systematic reorganization of autism service delivery may reduce delays and better meet the growing need. METHODS:Two clinical centers in the Autis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2851M

    authors: Austin J,Manning-Courtney P,Johnson ML,Weber R,Johnson H,Murray D,Ratliff-Schaub K,Tadlock AM,Murray M

    更新日期:2016-02-01 00:00:00

  • Assessment of musculoskeletal toxicity 5 years after therapy with levofloxacin.

    abstract:BACKGROUND:Safety concerns for fluoroquinolones exist from animal studies demonstrating cartilage injury in weight-bearing joints, dependent on dose and duration of therapy. For children treated with levofloxacin or comparator in randomized, prospective, comparative studies for acute otitis media and community-acquired...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.2013-3636

    authors: Bradley JS,Kauffman RE,Balis DA,Duffy CM,Gerbino PG,Maldonado SD,Noel GJ

    更新日期:2014-07-01 00:00:00

  • Tuberculosis in children 10 years of age and younger: three decades of experience during the chemotherapeutic era.

    abstract::The 863 patients, aged 10 years and younger, treated at the Children's Chest Clinic of Bellevue Hospital during three decades (1953 through 1981) clearly indicated the success of antituberculosis therapy. There were no deaths from tuberculosis. Early treatment is associated with a reduction in the serious forms of dis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Nemir RL,O'Hare D

    更新日期:1991-08-01 00:00:00

  • Impact of the thimerosal controversy on hepatitis B vaccine coverage of infants born to women of unknown hepatitis B surface antigen status in Michigan.

    abstract:OBJECTIVE:Hepatitis B vaccine is recommended for all infants, and the series may be started during the delivery admission. For infants who are born either to women who are positive for hepatitis B surface antigen (HBsAg) or to women whose HBsAg status is unknown, vaccination should be started within 12 hours of birth t...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.111.6.e645

    authors: Biroscak BJ,Fiore AE,Fasano N,Fineis P,Collins MP,Stoltman G

    更新日期:2003-06-01 00:00:00

  • Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children.

    abstract:OBJECTIVE:To evaluate the impact of 4 months of daily zinc supplementation on the incidence of severe and recurrent diarrhea in children 6 to 30 months of age. METHODS:A double-blind, randomized, placebo-controlled trial was conducted on children who were identified by a door-to-door survey to be aged 6 to 30 months a...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.109.6.e86

    authors: Bhandari N,Bahl R,Taneja S,Strand T,Mølbak K,Ulvik RJ,Sommerfelt H,Bhan MK

    更新日期:2002-06-01 00:00:00

  • Looking beyond the physical injury: posttraumatic stress disorder in children and parents after pediatric traffic injury.

    abstract:BACKGROUND:Traffic crashes are the leading health threat to children in the United States, resulting in nearly 1 million injuries annually. The psychological consequences of these injuries are primarily unknown. The aims of this study were to estimate the prevalence of posttraumatic stress disorder (PTSD) in traffic-in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.104.6.1293

    authors: de Vries AP,Kassam-Adams N,Cnaan A,Sherman-Slate E,Gallagher PR,Winston FK

    更新日期:1999-12-01 00:00:00

  • Chronic illness and mental health problems in pediatric practice: results from a survey of primary care providers.

    abstract::The prevalence of chronic physical illnesses and their association with mental disorders was assessed using data collected by primary care pediatricians. A chronic illness was diagnosed in 1573 (15.6%) of 10,058 children aged 4 to 16 years, 945 (9.4%) of whom had a "serious" disorder, 535 (5.3%) had a minor disorder (...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Weiland SK,Pless IB,Roghmann KJ

    更新日期:1992-03-01 00:00:00

  • Care coordination services in pediatric practices.

    abstract:OBJECTIVE:To examine the frequency with which pediatricians provide care coordination services to children, particularly those with special health care needs, in their practices and the barriers to providing these services. METHODS:An 8-page questionnaire was mailed to 1632 randomly selected US members of the American...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gupta VB,O'Connor KG,Quezada-Gomez C

    更新日期:2004-05-01 00:00:00

  • Translating child abuse research into action.

    abstract::The Child Abuse Recognition Experience Study revealed that primary care clinicians did not always follow the legal mandate to report suspected child abuse to child protective services. National child abuse experts representing different disciplines met in a 2-day conference in January 2007 to discuss and develop new s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0715c

    authors: Flaherty EG,Sege RD,Hurley TP

    更新日期:2008-09-01 00:00:00

  • Effects of waterbed flotation on premature infants: A pilot study.

    abstract::Two types of waterbeds were developed to impart compensatory vestibular-proprioceptive stimulation to premature infants. Twenty-one infants ranging in gestational age from 27 to 34 weeks and birthweights from 1,050 to 1,920 gm were included in this pilot study. Assignment to experimental and control groups was made by...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Korner AF,Kraemer HC,Haffner ME,Cosper LM

    更新日期:1975-09-01 00:00:00

  • Evaluation and treatment of the human immunodeficiency virus-1--exposed infant.

    abstract::In developed countries, care and treatment are available for pregnant women and infants that can decrease the rate of perinatal human immunodeficiency virus type 1 (HIV-1) infection to 2% or less. The pediatrician has a key role in prevention of mother-to-child transmission of HIV-1 by identifying HIV-exposed infants ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.114.2.497

    authors: King SM,American Academy of Pediatrics Committee on Pediatric AIDS.,American Academy of Pediatrics Infectious Diseases and Immunization Committee.

    更新日期:2004-08-01 00:00:00

  • Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature.

    abstract::Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plas...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.109.4.e67

    authors: Costello JM,Steinhorn D,McColley S,Gerber ME,Kumar SP

    更新日期:2002-04-01 00:00:00

  • Cholestasis and Hepatic Iron Deposition in an Infant With Complex Glycerol Kinase Deficiency.

    abstract::We present a 6-week-old male infant with persistent hyperbilirubinemia, hypertriglyceridemia, elevated creatine kinase levels, and transaminitis since the second week of life. When he developed hyperkalemia, clinical suspicion was raised for adrenal insufficiency despite hemodynamic stability. A full endocrine workup ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1479

    authors: Montoya-Williams D,Mowitz M

    更新日期:2017-07-01 00:00:00

  • The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children.

    abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.1.e6

    authors: Trepka MJ,Belongia EA,Chyou PH,Davis JP,Schwartz B

    更新日期:2001-01-01 00:00:00

  • Rumination syndrome in children and adolescents: diagnosis, treatment, and prognosis.

    abstract:OBJECTIVES:To characterize the clinical features, results of diagnostic testing, and treatment outcomes for children and adolescents with rumination syndrome. METHODS:Review of the medical records for all 147 patients ages 5 to 20 diagnosed with rumination syndrome at our institution between 1975 and 2000. Data are pr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.1.158

    authors: Chial HJ,Camilleri M,Williams DE,Litzinger K,Perrault J

    更新日期:2003-01-01 00:00:00

  • Fruit juice intake is not related to children's growth.

    abstract:BACKGROUND:Excessive fruit juice intake (>12 ounces/day) has been reported to be associated with short stature and obesity in preschool children. OBJECTIVE:To confirm whether excess fruit juice intake was associated with short stature and obesity in preschool children, we assessed growth parameters and fruit juice int...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.1.58

    authors: Skinner JD,Carruth BR,Moran J 3rd,Houck K,Coletta F

    更新日期:1999-01-01 00:00:00

  • Quality-of-life concerns differ among patients, parents, and medical providers in children and adolescents with congenital and acquired heart disease.

    abstract:OBJECTIVES:Mortality rates in pediatric patients with heart disease have decreased dramatically in recent decades, resulting in an increasing number of survivors with morbidities that impact quality of life. The purpose of this study was to assess and compare how heart disease affects the quality of life of the pediatr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2572

    authors: Marino BS,Tomlinson RS,Drotar D,Claybon ES,Aguirre A,Ittenbach R,Welkom JS,Helfaer MA,Wernovsky G,Shea JA

    更新日期:2009-04-01 00:00:00

  • Infection in the first 2 years of life and autism spectrum disorders.

    abstract:OBJECTIVE:The purpose of this work was to investigate the association between infections in the first 2 years and subsequent diagnosis of autism spectrum disorders. METHODS:We conducted a case-control study among children born at Kaiser Permanente Northern California from 1995 to 1999. Case subjects (n = 403) were chi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1788

    authors: Rosen NJ,Yoshida CK,Croen LA

    更新日期:2007-01-01 00:00:00

  • Fomepizole treatment of ethylene glycol poisoning in an infant.

    abstract::The enzyme alcohol dehydrogenase metabolizes ingested ethylene glycol (EG) to the toxic compounds glycolic and oxalic acids. Renal failure, acidosis, hypocalcemia, and death may follow. Traditional treatment of EG poisoning may require ethanol, a competitive substrate of alcohol dehydrogenase, and hemodialysis, that r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.1489

    authors: Baum CR,Langman CB,Oker EE,Goldstein CA,Aviles SR,Makar JK

    更新日期:2000-12-01 00:00:00

  • Treatment of child and adolescent obesity: reports from pediatricians, pediatric nurse practitioners, and registered dietitians.

    abstract:OBJECTIVE:The primary aim of this study was to identify interventions used by pediatric health care providers in treatment of overweight children and adolescents to identify provider educational needs. A secondary aim was to examine the association of certain provider characteristics with recommended evaluation practic...

    journal_title:Pediatrics

    pub_type: 评论,杂志文章

    doi:

    authors: Barlow SE,Trowbridge FL,Klish WJ,Dietz WH

    更新日期:2002-07-01 00:00:00

  • Interfacility transfers of noncritically ill children to academic pediatric emergency departments.

    abstract:OBJECTIVES:We aimed to characterize the demographics, diagnoses, and management of transferred patients who were directly discharged from the emergency department (ED) or admitted less than 24 hours. METHODS:We conducted a retrospective, cross-sectional study of patients classified as interfacility ED transfers over a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1819

    authors: Li J,Monuteaux MC,Bachur RG

    更新日期:2012-07-01 00:00:00

  • Erythropoietin concentrations and neurodevelopmental outcome in preterm infants.

    abstract:OBJECTIVE:Erythropoietin therapy is effective in decreasing transfusions to varying degrees in preterm infants. Recent animal studies using erythropoietin doses to achieve serum concentrations > 1000 mU/mL report neuroprotective effects. We evaluated the relationship between erythropoietin concentrations and neurodevel...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-3186

    authors: Bierer R,Peceny MC,Hartenberger CH,Ohls RK

    更新日期:2006-09-01 00:00:00

  • Two cases of diskitis attributable to anaerobic bacteria in children.

    abstract::Diskitis, an inflammation of the intervertebral disk, is generally attributable to Staphylococcus aureus and rarely Staphylococcus epidermidis, Kingella kingae, Enterobacteriaciae, and Streptococcus pneumoniae. In many cases, no bacterial growth is obtained from infected intervertebral discs. Although anaerobic bacter...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.2.e26

    authors: Brook I

    更新日期:2001-02-01 00:00:00

  • Recent trends in waist circumference and waist-height ratio among US children and adolescents.

    abstract:OBJECTIVES:Abdominal obesity may be a better predictor than overall obesity for the risk of cardiovascular disease and type 2 diabetes. Waist circumference and waist-height ratio are 2 simple, yet effective, surrogate measures of abdominal obesity. We sought to examine the recent trends in mean waist circumference and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1062

    authors: Li C,Ford ES,Mokdad AH,Cook S

    更新日期:2006-11-01 00:00:00

  • A system for individualized dosing of intravenous aminophylline using a programmable calculator.

    abstract::A program that calculates a value of clearance for an individual patient prior to reaching steady state in the early stages of aminophylline therapy is presented. The program is written for the Texas Instruments TI-59 programmable calculator and may be used with or without the PC-100C printer. The program can provide ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mitsuoka JC,Fleck RJ

    更新日期:1984-01-01 00:00:00

  • Improvement of short- and long-term outcomes for very low birth weight infants: Edmonton NIDCAP trial.

    abstract:OBJECTIVE:Our objective was to determine the impact of Newborn Individualized Developmental Care and Assessment Program (NIDCAP)-based care on length of stay of very low birth weight (VLBW) infants. Secondary outcome measures were days of ventilation, incidence of chronic lung disease, and 18-month neurodevelopmental o...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2008-3808

    authors: Peters KL,Rosychuk RJ,Hendson L,Coté JJ,McPherson C,Tyebkhan JM

    更新日期:2009-10-01 00:00:00

  • Sudden child death and 'healthy' affected family members with medium-chain acyl-coenzyme A dehydrogenase deficiency.

    abstract::A family is described in which the father and three (and probably all four) of his children had a decreased capacity for the oxidation of medium-chain fatty acids. One of the children suddenly died at the age of 16 months following an episode of a rapidly deteriorating Reye syndrome-like illness with hypoketotic hypog...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Duran M,Hofkamp M,Rhead WJ,Saudubray JM,Wadman SK

    更新日期:1986-12-01 00:00:00

  • Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.

    abstract:OBJECTIVE:Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections is hypothesized to be a poststreptococcal autoimmune disorder. If clinical exacerbations are triggered by a streptococcal infection that activates cross-reacting antibodies against neuronal tissue or alters the production...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2658

    authors: Singer HS,Gause C,Morris C,Lopez P,Tourette Syndrome Study Group.

    更新日期:2008-06-01 00:00:00

  • Ineffectiveness of historical data in predicting measles susceptibility.

    abstract::The Immunization Practices Advisory Committee ( ACIP ) has devised noninvasive, historical criteria for determining individuals who are susceptible to measles. These criteria, which involve proof of vaccination, are incorporated into school entrance regulations and are used to indicate people who require vaccination d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Scott RM,Butler AB,Schydlower M,Rawlings P

    更新日期:1984-06-01 00:00:00

  • Screening for neuroblastoma at 3 weeks of age: methods and preliminary results from the Quebec Neuroblastoma Screening Project.

    abstract::A large neuroblastoma screening study was recently started in the province of Quebec, Canada. This project, a collaboration between the Quebec Network for Genetic Medicine and the University of Minnesota, is studying the impact of screening infants for the preclinical detection of neuroblastoma on the population-based...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tuchman M,Lemieux B,Auray-Blais C,Robison LL,Giguere R,McCann MT,Woods WG

    更新日期:1990-11-01 00:00:00